Detailed view for TVAG_144010

Basic information

TDR Targets ID: 909629
Trichomonas vaginalis, CMGC family protein kinase

Source Database / ID: 

pI: 8.6064 | Length (AA): 394 | MW (Da): 44658 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131024)

Species Accession Gene Product
Giardia lamblia GL50803_14004   Long-flagella protein, kinase, CMGC RCK
Homo sapiens ENSG00000080823   MOK protein kinase
Leishmania braziliensis LbrM.34.4950   protein kinase, putative
Leishmania donovani LdBPK_355330.1   protein kinase, putative
Leishmania infantum LinJ.35.5330   protein kinase, putative
Leishmania major LmjF.35.5010   protein kinase, putative
Mus musculus ENSMUSG00000056458   MOK protein kinase
Schmidtea mediterranea mk4.001235.06  
Schmidtea mediterranea mk4.001235.05  
Trypanosoma brucei gambiense Tbg972.9.5250   protein kinase, putative
Trypanosoma brucei Tb927.9.9320   MAPK/MAK/MRK overlapping kinase, putative
Trypanosoma congolense TcIL3000_9_3400   protein kinase, putative
Trypanosoma cruzi TcCLB.506885.120   MAPK/MAK/MRK overlapping kinase, putative
Trichomonas vaginalis TVAG_328960   CMGC family protein kinase
Trichomonas vaginalis TVAG_144010   CMGC family protein kinase
Trichomonas vaginalis TVAG_272410   CMGC family protein kinase
Trichomonas vaginalis TVAG_057050   CMGC family protein kinase

Essentiality

TVAG_144010 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.211.0960 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb09.211.0960 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb09.211.0960 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.211.0960 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 35.3% 252 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 35.1% 174 aa Compounds References
Patiria pectinifera Cdc2 300 aa 36.3% 245 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 35.5% 248 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 35.9% 251 aa Compounds References

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0008 0.5 0.5
0.0011 1 0.5
0.0029 0.5 0.5
0.0092 1 0.5
0.0007 0.5 0.5
0.0023 0.5 0.5
0.0039 0.9485 0.5
0.0098 0.3242 0.2373
0.0059 1 1
0.0062 0.6935 0.5
0.0066 0.3101 0.5
0.0027 1 0.5
0.0016 0.5 0.5
0.0067 0.5 0.5
0.0039 0.5 0.5
0.0061 0.6883 0.5304
0.0036 0.5 0.5
0.0026 0.5 0.5
0.0042 0.5 0.5
0.0018 0.5 0.5
0.0059 1 1
0.0069 0.3067 0.5
0.0004 0.5 0.5
0.0081 0.5 0.5
0.0091 1 0.5
0.0033 0.5 0.5
0.0063 1 1
0.0007 0.5 0.5
0.0033 1 1
0.0016 0.5 0.5
0.0012 0.5 0.5
0.0007 0.5 0.5
0.0037 1 0.5
0.0032 0.5 0.5
0.0039 0.5 0.5
0.0003 0.5 0.5
0.0012 0.5 0.5
0.0012 0.5 0.5
0.0056 1 0.5
0.0088 0.4477 1
0.0081 1 0.5
0.0093 0.8828 0.5
0.0032 0.5 0.5
0.0059 1 1
0.0022 0.5 0.5
0.0063 0.7244 0
0.0064 0.3377 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_144010 (Trichomonas vaginalis), CMGC family protein kinase
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