pI: 8.6064 |
Length (AA): 394 |
MW (Da): 44658 |
Paralog Number:
3
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_131024)
Species | Accession | Gene Product |
---|---|---|
Giardia lamblia | GL50803_14004 | Long-flagella protein, kinase, CMGC RCK |
Homo sapiens | ENSG00000080823 | MOK protein kinase |
Leishmania braziliensis | LbrM.34.4950 | protein kinase, putative |
Leishmania donovani | LdBPK_355330.1 | protein kinase, putative |
Leishmania infantum | LinJ.35.5330 | protein kinase, putative |
Leishmania major | LmjF.35.5010 | protein kinase, putative |
Mus musculus | ENSMUSG00000056458 | MOK protein kinase |
Schmidtea mediterranea | mk4.001235.06 | |
Schmidtea mediterranea | mk4.001235.05 | |
Trypanosoma brucei gambiense | Tbg972.9.5250 | protein kinase, putative |
Trypanosoma brucei | Tb927.9.9320 | MAPK/MAK/MRK overlapping kinase, putative |
Trypanosoma congolense | TcIL3000_9_3400 | protein kinase, putative |
Trypanosoma cruzi | TcCLB.506885.120 | MAPK/MAK/MRK overlapping kinase, putative |
Trichomonas vaginalis | TVAG_328960 | CMGC family protein kinase |
Trichomonas vaginalis | TVAG_144010 | CMGC family protein kinase |
Trichomonas vaginalis | TVAG_272410 | CMGC family protein kinase |
Trichomonas vaginalis | TVAG_057050 | CMGC family protein kinase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb09.211.0960 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb09.211.0960 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb09.211.0960 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb09.211.0960 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Homo sapiens | Cyclin-dependent kinase 1/cyclin B1 | 297 aa | 35.3% | 252 aa | Compounds | References |
Oryctolagus cuniculus | Cyclin-dependent kinase 4 | 189 aa | 35.1% | 174 aa | Compounds | References |
Patiria pectinifera | Cdc2 | 300 aa | 36.3% | 245 aa | Compounds | References |
Rattus norvegicus | Cell division protein kinase 5 | 292 aa | 35.5% | 248 aa | Compounds | References |
Plasmodium falciparum (isolate 3D7) | Cell division control protein 2 homolog | 288 aa | 35.9% | 251 aa | Compounds | References |