pI: 9.7952 |
Length (AA): 519 |
MW (Da): 60945 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
294 | 470 | 1ta0 (A) | 77 | 255 | 23.00 | 0 | 1 | 0.73 | -0.99 |
306 | 471 | 1ta0 (A) | 77 | 256 | 25.00 | 0 | 1 | 0.54 | -1.21 |
290 | 483 | 4qqf (A) | 161 | 355 | 31.00 | 0 | 1 | 0.755996 | -0.18 |
292 | 483 | 4qqf (A) | 162 | 355 | 30.00 | 0.000000000017 | 1 | 0.747542 | -0.43 |
345 | 458 | 2ght (A) | 129 | 241 | 36.00 | 0.0000000019 | 1 | 0.571053 | 0.2 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | early trophozoite, late ring, late trophozoite, Oocyst, Sporozoite. | PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, gametocyte, sporozoite, early ring, early schizont, late schizont, Ring, Male Gametocyte. | Otto TD PlasmoDB Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Female Gametocyte. | Otto TD Lasonder E |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Ortholog group members (OG5_128978)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G55900 | mitochondrial import inner membrane translocase subunit TIM50 |
Babesia bovis | BBOV_III011630 | conserved hypothetical protein |
Brugia malayi | Bm1_51810 | NLI interacting factor-like phosphatase family protein |
Candida albicans | CaO19.680 | similar to S. cerevisiae TIM50 (YPL063W) mitochondrial inner membrane pre-sequence translocase complex guide protein |
Candida albicans | CaO19.8297 | similar to S. cerevisiae TIM50 (YPL063W) mitochondrial inner membrane pre-sequence translocase complex guide protein |
Caenorhabditis elegans | CELE_T21C9.12 | Protein SCPL-4 |
Cryptosporidium hominis | Chro.80393 | hypothetical protein |
Cryptosporidium parvum | cgd8_3400 | RNA polymerase II CTD/NL1 interacting protein like phosphatase |
Drosophila melanogaster | Dmel_CG6691 | tiny tim 3 |
Drosophila melanogaster | Dmel_CG2713 | tiny tim 50 |
Echinococcus granulosus | EgrG_000466000 | mitochondrial import inner membrane translocase |
Echinococcus multilocularis | EmuJ_000466000 | mitochondrial import inner membrane translocase |
Homo sapiens | ENSG00000105197 | translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) |
Loa Loa (eye worm) | LOAG_04917 | import inner membrane translocase subunit TIM50 |
Mus musculus | 66525 | translocase of inner mitochondrial membrane 50 |
Neospora caninum | NCLIV_015350 | hypothetical protein, conserved |
Oryza sativa | 4339299 | Os05g0513200 |
Oryza sativa | 9269938 | Os01g0762400 |
Plasmodium berghei | PBANKA_0211000 | mitochondrial import inner membrane translocase subunit TIM50, putative |
Plasmodium falciparum | PF3D7_0726900 | mitochondrial import inner membrane translocase subunit TIM50, putative |
Plasmodium knowlesi | PKNH_0211500 | mitochondrial import inner membrane translocase subunit TIM50, putative |
Plasmodium vivax | PVX_081650 | mitochondrial import inner membrane translocase subunit TIM50, putative |
Plasmodium yoelii | PY02099 | Unknown, putative |
Saccharomyces cerevisiae | YPL063W | Tim50p |
Schistosoma japonicum | Sjp_0303370 | Import inner membrane translocase subunit TIM50-C, mitochondrial precursor, putative |
Schistosoma mansoni | Smp_024360.1 | translocase of inner mitochondrial membrane 50-related |
Schistosoma mansoni | Smp_024360.2 | translocase of inner mitochondrial membrane 50-related |
Schmidtea mediterranea | mk4.000427.03 | Mitochondrial import inner membrane translocase subunit TIM50 |
Toxoplasma gondii | TGME49_283590 | NLI interacting factor family phosphatase |
Theileria parva | TP01_1007 | hypothetical protein, conserved |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_T21C9.12 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T21C9.12 | Caenorhabditis elegans | slow growth | wormbase |
CELE_T21C9.12 | Caenorhabditis elegans | sterile | wormbase |
YPL063W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0211000 | Plasmodium berghei | Essential | plasmo |
TGME49_283590 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.