Detailed view for TVAG_417060

Basic information

TDR Targets ID: 911513
Trichomonas vaginalis, conserved hypothetical protein
Source Database / ID: 

pI: 7.6781 | Length (AA): 1007 | MW (Da): 110792 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF15780   Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132778)

Species Accession Gene Product
Homo sapiens ENSG00000142609   cilia and flagella associated protein 74
Homo sapiens 339457   uncharacterized protein C1orf222
Leishmania braziliensis LbrM.18.0630   hypothetical protein, conserved
Leishmania donovani LdBPK_180570.1   hypothetical protein, conserved
Leishmania infantum LinJ.18.0570   hypothetical protein, conserved
Leishmania major LmjF.18.0570   hypothetical protein, conserved
Leishmania mexicana LmxM.18.0570   hypothetical protein, conserved
Mus musculus ENSMUSG00000078490   cilia and flagella associated protein 74
Neospora caninum NCLIV_012420   Flagellar associated protein, related
Schistosoma japonicum Sjp_0113110   expressed protein
Schistosoma japonicum Sjp_0025580   expressed protein
Schistosoma japonicum Sjp_0096940   Conserved hypothetical protein
Schistosoma mansoni Smp_165060   hypothetical protein
Trypanosoma brucei gambiense Tbg972.10.16370   hypothetical protein, conserved
Trypanosoma brucei Tb927.10.13550   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_10_11640   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.511277.220   hypothetical protein, conserved
Toxoplasma gondii TGME49_220290   hypothetical protein
Trichomonas vaginalis TVAG_068880   conserved hypothetical protein
Trichomonas vaginalis TVAG_417060   conserved hypothetical protein

Essentiality

TVAG_417060 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.13550 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.13550 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.13550 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.13550 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_220290 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_417060 (Trichomonas vaginalis), conserved hypothetical protein
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