Detailed view for TVAG_198710

Basic information

TDR Targets ID: 915000
Trichomonas vaginalis, c2h2 zinc finger protein, putative
Source Database / ID: 

pI: 7.3887 | Length (AA): 474 | MW (Da): 53623 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00536   SAM domain (Sterile alpha motif)
PF13913   zinc-finger of a C2HC-type

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129716)

Species Accession Gene Product
Caenorhabditis elegans CELE_M153.4   Protein M153.4
Drosophila melanogaster Dmel_CG42675   CG42675 gene product from transcript CG42675-RF
Echinococcus granulosus EgrG_000373700   zinc finger protein 474
Echinococcus granulosus EgrG_000889800   zinc finger protein 474
Echinococcus multilocularis EmuJ_000889800   zinc finger protein 474
Echinococcus multilocularis EmuJ_000373700   zinc finger protein 474
Giardia lamblia GL50803_8405   Hypothetical protein
Homo sapiens ENSG00000164185   zinc finger protein 474
Homo sapiens 100505841   zinc finger protein 474-like
Leishmania braziliensis LbrM.18.0090   hypothetical protein, conserved
Leishmania donovani LdBPK_180070.1   zinc-finger of a C2HC-type/Double zinc ribbon, putative
Leishmania infantum LinJ.18.0070   hypothetical protein, conserved
Leishmania major LmjF.18.0070   hypothetical protein, conserved
Leishmania mexicana LmxM.18.0070   hypothetical protein, conserved
Mus musculus ENSMUSG00000024532   RIKEN cDNA 1700034E13 gene
Mus musculus ENSMUSG00000046886   zinc finger protein 474
Schistosoma japonicum Sjp_0020790   Zinc finger protein 474, putative
Trypanosoma brucei gambiense Tbg972.10.16710   hypothetical protein, conserved
Trypanosoma brucei Tb927.10.13610   zinc-finger of a C2HC-type/Double zinc ribbon, putative
Trypanosoma congolense TcIL3000_10_13860   zinc-finger of a C2HC-type/Double zinc ribbon, putative
Trypanosoma cruzi TcCLB.507993.280   zinc-finger of a C2HC-type/Double zinc ribbon, putative
Trypanosoma cruzi TcCLB.508893.20   zinc-finger of a C2HC-type/Double zinc ribbon, putative
Trichomonas vaginalis TVAG_198710   c2h2 zinc finger protein, putative
Trichomonas vaginalis TVAG_324760   c2h2 zinc finger protein, putative
Trichomonas vaginalis TVAG_237340   cgi-62, putative
Trichomonas vaginalis TVAG_437140   c2h2 zinc finger protein, putative

Essentiality

TVAG_198710 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.13610 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.13610 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.13610 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.13610 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_198710 (Trichomonas vaginalis), c2h2 zinc finger protein, putative
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