Detailed view for TVAG_159540

Basic information

TDR Targets ID: 918439
Trichomonas vaginalis, leucine rich repeat-containing protein, putative
Source Database / ID: 

pI: 6.6614 | Length (AA): 729 | MW (Da): 80383 | Paralog Number: 11

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13516   Leucine Rich repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128963)

Species Accession Gene Product
Arabidopsis thaliana AT1G10510   protein EMB2004
Dictyostelium discoideum DDB_G0278635   leucine-rich repeat-containing protein
Dictyostelium discoideum DDB_G0290485   hypothetical protein
Homo sapiens ENSG00000167984   NLR family, CARD domain containing 3
Leishmania braziliensis LbrM.26.0520   hypothetical protein, conserved
Leishmania braziliensis LbrM.29.2870   ribonuclease inhibitor-like protein
Leishmania donovani LdBPK_260490.1   hypothetical protein, conserved
Leishmania donovani LdBPK_292920.1   ribonuclease inhibitor-like protein
Leishmania infantum LinJ.26.0490   hypothetical protein, conserved
Leishmania infantum LinJ.29.2920   ribonuclease inhibitor-like protein
Leishmania major LmjF.29.2810   ribonuclease inhibitor-like protein
Leishmania major LmjF.26.0500   hypothetical protein, conserved
Leishmania mexicana LmxM.26.0500   hypothetical protein, conserved
Leishmania mexicana LmxM.08_29.2810  
Mus musculus 268857   NLR family, CARD domain containing 3
Oryza sativa 4340606   Os06g0237400
Schmidtea mediterranea mk4.005930.02  
Trypanosoma brucei gambiense Tbg972.7.1430   hypothetical protein, conserved,leucine-rich repeat protein (LRRP), putative
Trypanosoma brucei gambiense Tbg972.3.3030   hypothetical protein, conserved
Trypanosoma brucei Tb927.3.2950   ribonuclease inhibitor- like protein
Trypanosoma brucei Tb927.7.1430   leucine-rich repeat protein (LRRP), putative
Trypanosoma congolense TcIL3000_0_29380   leucine-rich repeat protein (LRRP), putative
Trypanosoma congolense TcIL3000_3_1860   ribonuclease inhibitor- like protein
Trypanosoma cruzi TcCLB.503579.20   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.507517.10   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.506693.50   ribonuclease inhibitor-like protein, putative
Trichomonas vaginalis TVAG_047040   card15, putative
Trichomonas vaginalis TVAG_215100   leucine rich repeat-containing protein, putative
Trichomonas vaginalis TVAG_204150   leucine rich repeat-containing protein, putative
Trichomonas vaginalis TVAG_472630   leucine rich repeat-containing protein, putative
Trichomonas vaginalis TVAG_296710   nalp 13
Trichomonas vaginalis TVAG_439720   leucine rich repeat and nacht domain-containing protein, putative
Trichomonas vaginalis TVAG_476800   leucine rich repeat-containing protein, putative
Trichomonas vaginalis TVAG_349380   nalp 4
Trichomonas vaginalis TVAG_441550   leucine rich repeat-containing protein, putative
Trichomonas vaginalis TVAG_159540   leucine rich repeat-containing protein, putative
Trichomonas vaginalis TVAG_075380   leucine rich repeat-containing protein, putative
Trichomonas vaginalis TVAG_056420   leucine rich repeat-containing protein, putative

Essentiality

TVAG_159540 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.3.2950 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.3.2950 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.3.2950 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.3.2950 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.7.1430 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.7.1430 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.7.1430 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.7.1430 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_159540 (Trichomonas vaginalis), leucine rich repeat-containing protein, putative
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