Detailed view for TVAG_281080
Basic information
TDR Targets ID: 919627
Trichomonas vaginalis, guanylate cyclase, putative
Source Database / ID:
Trichomonas vaginalis, guanylate cyclase, putative
Source Database / ID:
pI: 6.4494 |
Length (AA): 1549 |
MW (Da): 175321 |
Paralog Number:
179
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 13
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Pfam domains
PF00211
Adenylate and Guanylate cyclase catalytic domain
Gene Ontology
Mouse over links to read term descriptions.
GO:0035556
GO:intracellular signal transduction GO:0016849 phosphorus-oxygen lyase activity
GO:0009190 cyclic nucleotide biosynthetic process
Metabolic Pathways
This gene is not mapped to any metabolic pathway in KEGG.
Structural information
Modbase 3D models:
No model available for this protein in Modbase.
PDB Structures:
No structure availble in the PDB for this protein
Expression
No expression data available for this gene
Orthologs
Ortholog group members (OG5_126770)
| Species | Accession | Gene Product |
|---|---|---|
| Brugia malayi | Bm1_15000 | Adenylate and Guanylate cyclase catalytic domain containing protein |
| Dictyostelium discoideum | DDB_G0274569 | adenylate cyclase |
| Loa Loa (eye worm) | LOAG_13680 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_03815 | hypothetical protein |
| Mycobacterium tuberculosis | Rv1625c | Membrane-anchored adenylyl cyclase Cya (ATP pyrophosphate-lyase) (adenylate cyclase) |
| Mycobacterium ulcerans | MUL_2284 | hypothetical protein |
| Trichomonas vaginalis | TVAG_327930 | adenylate cyclase, putative |
| Trichomonas vaginalis | TVAG_298220 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_021840 | adenylate cyclase, type VII, putative |
| Trichomonas vaginalis | TVAG_162120 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_298410 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_273280 | adenylate cyclase, putative |
| Trichomonas vaginalis | TVAG_451980 | guanylate cyclase, putative |
| Trichomonas vaginalis | TVAG_124800 | adenylate cyclase, putative |
| Trichomonas vaginalis | TVAG_358630 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_391080 | guanylate cyclase, putative |
| Trichomonas vaginalis | TVAG_116480 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_298390 | soluble guanylate cyclase gcy, putative |
| Trichomonas vaginalis | TVAG_322510 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_052910 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_411720 | adenylate cyclase type VI, putative |
| Trichomonas vaginalis | TVAG_024960 | adenylate cyclase type IX, putative |
| Trichomonas vaginalis | TVAG_124790 | adenylate and guanylate cyclases, putative |
| Trichomonas vaginalis | TVAG_219760 | guanylate cyclase, putative |
| Trichomonas vaginalis | TVAG_411240 | adenylate cyclase, type VII, putative |
| Trichomonas vaginalis | TVAG_360130 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_336830 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_162110 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_155240 | adenylate cyclase type IX, putative |
| Trichomonas vaginalis | TVAG_431840 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_291050 | guanylate cyclase, putative |
| Trichomonas vaginalis | TVAG_127600 | guanylate cyclase, putative |
| Trichomonas vaginalis | TVAG_383510 | guanylate cyclase, putative |
| Trichomonas vaginalis | TVAG_102500 | adenylate and guanylate cyclases, putative |
| Trichomonas vaginalis | TVAG_270460 | adenylate cyclase, putative |
| Trichomonas vaginalis | TVAG_101980 | soluble guanylate cyclase gcy, putative |
| Trichomonas vaginalis | TVAG_360120 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_363510 | guanylate cyclase, putative |
| Trichomonas vaginalis | TVAG_406770 | adenylate cyclase, putative |
| Trichomonas vaginalis | TVAG_360140 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_098530 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_357240 | guanylate cyclase beta 2 subunit, putative |
| Trichomonas vaginalis | TVAG_098520 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_228010 | adenylate cyclase, putative |
| Trichomonas vaginalis | TVAG_353640 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_036810 | guanylate cyclase, putative |
| Trichomonas vaginalis | TVAG_604010 | guanylate cyclase beta 2 subunit, putative |
| Trichomonas vaginalis | TVAG_017920 | adenylate cyclase, putative |
| Trichomonas vaginalis | TVAG_038510 | guanylate cyclase, putative |
| Trichomonas vaginalis | TVAG_344240 | adenylate cyclase, putative |
| Trichomonas vaginalis | TVAG_353630 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_360150 | soluble guanylate cyclase gcy, putative |
| Trichomonas vaginalis | TVAG_451970 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_399750 | adenylate cyclase type VI, putative |
| Trichomonas vaginalis | TVAG_383490 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_213300 | adenylate cyclase, putative |
| Trichomonas vaginalis | TVAG_373640 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_420130 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_194370 | adenylate cyclase, putative |
| Trichomonas vaginalis | TVAG_281080 | guanylate cyclase, putative |
| Trichomonas vaginalis | TVAG_459500 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_373670 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_365230 | guanylate cyclase, putative |
| Trichomonas vaginalis | TVAG_411250 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_489980 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_052920 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_219670 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_247080 | adenylate cyclase, putative |
| Trichomonas vaginalis | TVAG_373630 | guanylate cyclase, putative |
| Trichomonas vaginalis | TVAG_298210 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_415250 | adenylate cyclase type IX, putative |
| Trichomonas vaginalis | TVAG_219680 | guanylate cyclase beta 1 subunit, putative |
| Trichomonas vaginalis | TVAG_082230 | retinal guanylate cyclase, putative |
| Trichomonas vaginalis | TVAG_095290 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_255630 | adenylate cyclase type III, putative |
| Trichomonas vaginalis | TVAG_453250 | adenylate and guanylate cyclases, putative |
| Trichomonas vaginalis | TVAG_062940 | atrial natriuretic peptide receptor, putative |
| Trichomonas vaginalis | TVAG_119490 | adenylate and guanylate cyclases, putative |
| Trichomonas vaginalis | TVAG_087300 | adenylate and guanylate cyclases, putative |
| Trichomonas vaginalis | TVAG_072540 | guanylate cyclase, putative |
| Trichomonas vaginalis | TVAG_406780 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_116470 | intestinal guanylate cyclase, putative |
| Trichomonas vaginalis | TVAG_057590 | guanylate cyclase, putative |
| Trichomonas vaginalis | TVAG_431830 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_158250 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_151410 | adenylyl cyclase type V, putative |
| Trichomonas vaginalis | TVAG_017910 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_008510 | adenylate cyclase, putative |
| Trichomonas vaginalis | TVAG_336810 | guanylate cyclase, putative |
| Trichomonas vaginalis | TVAG_406790 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_287980 | adenylate cyclase, putative |
| Trichomonas vaginalis | TVAG_TEG_DS113747_3_1 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_008520 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_228390 | adenylate and guanylate cyclases, putative |
| Trichomonas vaginalis | TVAG_138040 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_391070 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_451130 | guanylate cyclase, putative |
| Trichomonas vaginalis | TVAG_218150 | adenylate cyclase, putative |
| Trichomonas vaginalis | TVAG_194440 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_147310 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_057580 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_303820 | atrial natriuretic peptide receptor, putative |
| Trichomonas vaginalis | TVAG_255620 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_021130 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_318180 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_284780 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_145640 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_505880 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_025690 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_158530 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_034630 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_136140 | guanylate cyclase, putative |
| Trichomonas vaginalis | TVAG_457380 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_459490 | guanylate cyclase, putative |
| Trichomonas vaginalis | TVAG_124920 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_299950 | adenylate cyclase, putative |
| Trichomonas vaginalis | TVAG_235080 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_456550 | adenylate and guanylate cyclases, putative |
| Trichomonas vaginalis | TVAG_101890 | adenylate cyclase type IX, putative |
| Trichomonas vaginalis | TVAG_145650 | adenylate cyclase type III, putative |
| Trichomonas vaginalis | TVAG_051550 | adenylate and guanylate cyclases, putative |
| Trichomonas vaginalis | TVAG_446260 | guanylate cyclase, putative |
| Trichomonas vaginalis | TVAG_457220 | adenylate cyclase type, putative |
| Trichomonas vaginalis | TVAG_344250 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_128850 | adenylate and guanylate cyclases, putative |
| Trichomonas vaginalis | TVAG_490080 | guanylate cyclase, putative |
| Trichomonas vaginalis | TVAG_186390 | guanylate cyclase, putative |
| Trichomonas vaginalis | TVAG_072530 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_168430 | adenylate and guanylate cyclases, putative |
| Trichomonas vaginalis | TVAG_138030 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_425200 | adenylate cyclase, putative |
| Trichomonas vaginalis | TVAG_052960 | guanylate cyclase, putative |
| Trichomonas vaginalis | TVAG_124910 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_158550 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_303810 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_167510 | adenylate and guanylate cyclases, putative |
| Trichomonas vaginalis | TVAG_273290 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_353620 | retinal guanylate cyclase, putative |
| Trichomonas vaginalis | TVAG_392570 | guanylate cyclase, putative |
| Trichomonas vaginalis | TVAG_052940 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_358620 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_350120 | guanylate cyclase, putative |
| Trichomonas vaginalis | TVAG_489970 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_350270 | adenylate and guanylate cyclases, putative |
| Trichomonas vaginalis | TVAG_425640 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_127610 | adenylate cyclase type, putative |
| Trichomonas vaginalis | TVAG_052950 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_095300 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_373660 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_365240 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_147320 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_467090 | adenylate cyclase, putative |
| Trichomonas vaginalis | TVAG_082220 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_162100 | soluble guanylate cyclase gcy, putative |
| Trichomonas vaginalis | TVAG_021120 | guanylate cyclase, putative |
| Trichomonas vaginalis | TVAG_052930 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_298400 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_406800 | adenylate and guanylate cyclases, putative |
| Trichomonas vaginalis | TVAG_357550 | guanylate cyclase, putative |
| Trichomonas vaginalis | TVAG_391060 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_101990 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_318170 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_383500 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_138020 | soluble guanylate cyclase gcy, putative |
| Trichomonas vaginalis | TVAG_318160 | guanylate cyclase, putative |
| Trichomonas vaginalis | TVAG_336820 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_013980 | guanylate cyclase, putative |
| Trichomonas vaginalis | TVAG_284770 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_124900 | adenylate cyclase, putative |
| Trichomonas vaginalis | TVAG_092700 | adenylyl cyclase type V, putative |
| Trichomonas vaginalis | TVAG_158540 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_436960 | adenylate cyclase type, putative |
| Trichomonas vaginalis | TVAG_431850 | adenylate and guanylate cyclases, putative |
| Trichomonas vaginalis | TVAG_373650 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_315830 | adenylate and guanylate cyclases, putative |
| Trichomonas vaginalis | TVAG_581670 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_564290 | adenylate cyclase type III, putative |
| Trichomonas vaginalis | TVAG_145630 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_298230 | guanylate cyclase, putative |
| Trichomonas vaginalis | TVAG_052900 | guanylate cyclase, putative |
| Trichomonas vaginalis | TVAG_307730 | guanylate cyclase, putative |
| Trichomonas vaginalis | TVAG_290500 | guanylate cyclase, putative |
| Trichomonas vaginalis | TVAG_098510 | soluble guanylate cyclase gcy, putative |
| Trichomonas vaginalis | TVAG_302910 | adenylate cyclase, putative |
| Trichomonas vaginalis | TVAG_415270 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_406810 | conserved hypothetical protein |
Essentiality
No essentiality data collected for this gene and/or its orthologs.
Phenotypes and Validation (curated)
We have no manually annotated phenotypes for this target.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
No validation data for this target
Associated compounds / Druggability
Known modulators for this target
No chemical compounds associated to this gene
Predicted associations
By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model
Assayability
Assay information
No assay information for this target.
Reagent availability
No reagent availability information for this target.
Bibliographic References
No literature references available for this target.
If you have references for this gene, please enter them in a user comment (below) or Contact us.
User comments
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