Detailed view for TVAG_178730

Basic information

TDR Targets ID: 921026
Trichomonas vaginalis, striatin, putative
Source Database / ID: 

pI: 7.0779 | Length (AA): 481 | MW (Da): 53161 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00400   WD domain, G-beta repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128956)

Species Accession Gene Product
Brugia malayi Bm1_52045   Striatin 3
Caenorhabditis elegans CELE_K07C5.8   Protein CASH-1
Dictyostelium discoideum DDB_G0288327   WD40 repeat-containing protein
Drosophila melanogaster Dmel_CG7392   Connector of kinase to AP-1
Echinococcus granulosus EgrG_000121400   striatin
Echinococcus granulosus EgrG_000466700   striatin
Echinococcus multilocularis EmuJ_000121400   striatin
Echinococcus multilocularis EmuJ_000466700   striatin
Homo sapiens ENSG00000196792   striatin, calmodulin binding protein 3
Homo sapiens ENSG00000090372   striatin, calmodulin binding protein 4
Homo sapiens ENSG00000115808   striatin, calmodulin binding protein
Loa Loa (eye worm) LOAG_04706   hypothetical protein
Mus musculus ENSMUSG00000024077   striatin, calmodulin binding protein
Mus musculus ENSMUSG00000030374   striatin, calmodulin binding protein 4
Mus musculus ENSMUSG00000020954   striatin, calmodulin binding protein 3
Schistosoma japonicum Sjp_0099000   Striatin-3, putative
Schistosoma japonicum Sjp_0042010   Striatin, putative
Schistosoma japonicum Sjp_0133750   Striatin, putative
Schistosoma japonicum Sjp_0309850   Striatin-3, putative
Schistosoma japonicum Sjp_0316570   Striatin-3, putative
Schistosoma mansoni Smp_166080.1   striatin
Schistosoma mansoni Smp_166080.2   striatin
Schistosoma mansoni Smp_141040   striatin
Schmidtea mediterranea mk4.001496.01   Connector of kinase to AP-1
Schmidtea mediterranea mk4.002691.03  
Schmidtea mediterranea mk4.001496.03  
Schmidtea mediterranea mk4.003226.00  
Schmidtea mediterranea mk4.002691.05  
Schmidtea mediterranea mk4.001048.02  
Trichomonas vaginalis TVAG_063820   striatin, putative
Trichomonas vaginalis TVAG_178730   striatin, putative

Essentiality

TVAG_178730 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_K07C5.8 Caenorhabditis elegans larval arrest wormbase
CELE_K07C5.8 Caenorhabditis elegans larval lethal wormbase
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_178730 (Trichomonas vaginalis), striatin, putative
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