pI: 7.7588 |
Length (AA): 224 |
MW (Da): 26313 |
Paralog Number:
4
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_128515)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G18335 | acyl-CoA N-acyltransferases-like protein |
Babesia bovis | BBOV_III001570 | acetyltransferase, GNAT family protein |
Brugia malayi | Bm1_53215 | acetyltransferase, GNAT family protein |
Candida albicans | CaO19.4664 | potential N-acetyl tranferase (GNAT) superfamily protein with weak similarity to S. cerevisiae NAT4 (YMR069W) histone acetyltran |
Caenorhabditis elegans | CELE_Y38A10A.7 | Protein Y38A10A.7 |
Cryptosporidium hominis | Chro.60217 | hypothetical protein |
Cryptosporidium parvum | cgd6_1800 | acetyltransferase, GNAT family |
Drosophila melanogaster | Dmel_CG7593 | CG7593 gene product from transcript CG7593-RA |
Echinococcus granulosus | EgrG_001036500 | n alpha acetyltransferase 40 NatD catalytic |
Entamoeba histolytica | EHI_061000 | acetyltransferase, putative |
Echinococcus multilocularis | EmuJ_001036500 | n alpha acetyltransferase 40, NatD catalytic |
Homo sapiens | ENSG00000110583 | N(alpha)-acetyltransferase 40, NatD catalytic subunit |
Loa Loa (eye worm) | LOAG_06868 | hypothetical protein |
Mus musculus | ENSMUSG00000024764 | N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae) |
Neospora caninum | NCLIV_030730 | acetyltransferase domain-containing protein, putative |
Oryza sativa | 4338664 | Os05g0387800 |
Oryza sativa | 4330878 | Os02g0772300 |
Plasmodium berghei | PBANKA_1338500 | acetyltransferase, GNAT family, putative |
Plasmodium falciparum | PF3D7_1323300 | acetyltransferase, GNAT family, putative |
Plasmodium knowlesi | PKNH_1205500 | acetyltransferase, GNAT family, putative |
Plasmodium vivax | PVX_116705 | N-acetyltransferase, putative |
Plasmodium yoelii | PY04599 | acetyltransferase, GNAT family, putative |
Saccharomyces cerevisiae | YMR069W | Nat4p |
Schistosoma japonicum | Sjp_0102940 | ko:K00680 N-acetyltransferase [EC:2.3.1.-], putative |
Schistosoma mansoni | Smp_115340 | acetyltransferase (gnat) family containing protein |
Toxoplasma gondii | TGME49_230060 | acetyltransferase, GNAT family protein |
Theileria parva | TP03_0684 | hypothetical protein |
Trichomonas vaginalis | TVAG_213690 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_064180 | spcc825.04C protein, putative |
Trichomonas vaginalis | TVAG_275960 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_319280 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_083480 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
TGME49_230060 | Toxoplasma gondii | Essentiality uncertain | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.