pI: 8.7419 |
Length (AA): 111 |
MW (Da): 12556 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_127384)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G54940 | translation initiation factor SUI1 family protein |
Arabidopsis thaliana | AT1G54290 | protein translation factor SUI1-2 |
Arabidopsis thaliana | AT4G27130 | protein translation factor SUI1-1 |
Arabidopsis thaliana | AT5G54760 | translation initiation factor SUI1 family protein |
Babesia bovis | BBOV_III003030 | translation initiation factor SUI1, putative |
Candida albicans | CaO19.8867 | similar to S. cerevisiae SUI1 (YNL244C)16kD subunit of translation initiation factor eIF3 which has a role in start site selecti |
Candida albicans | CaO19.1280 | similar to S. cerevisiae SUI1 (YNL244C)16kD subunit of translation initiation factor eIF3 which has a role in start site selecti |
Caenorhabditis elegans | CELE_T27F7.3 | Protein EIF-1 |
Cryptosporidium hominis | Chro.20093 | translation initiation factor SUI1 |
Cryptosporidium parvum | cgd2_820 | putative translation initiation factor 1 (eIF1), SUI1p |
Dictyostelium discoideum | DDB_G0274239 | eukaryotic translation initiation factor 1 |
Drosophila melanogaster | Dmel_CG17737 | CG17737 gene product from transcript CG17737-RA |
Echinococcus granulosus | EgrG_000144100 | protein translation factor sui1 |
Entamoeba histolytica | EHI_179390 | Translation initiation factor, putative |
Echinococcus multilocularis | EmuJ_000144100 | protein translation factor sui1 |
Echinococcus multilocularis | EmuJ_000140400 | protein translation factor sui1 |
Giardia lamblia | GL50803_1657 | Translation initiation factor |
Homo sapiens | ENSG00000114784 | eukaryotic translation initiation factor 1B |
Homo sapiens | 10209 | eukaryotic translation initiation factor 1 |
Leishmania braziliensis | LbrM.24.1230 | translation factor sui1, putative |
Leishmania donovani | LdBPK_241240.1 | Eukaryotic translation initiation factor 1, putative |
Leishmania infantum | LinJ.24.1240 | translation factor sui1, putative |
Leishmania major | LmjF.24.1210 | translation factor sui1, putative |
Leishmania mexicana | LmxM.24.1210 | translation factor sui1, putative |
Mus musculus | ENSMUSG00000035530 | eukaryotic translation initiation factor 1 |
Mus musculus | 102633525 | predicted gene, 31332 |
Mus musculus | 102639922 | predicted gene 10157 |
Mus musculus | ENSMUSG00000006941 | eukaryotic translation initiation factor 1B |
Neospora caninum | NCLIV_065570 | translation initiation factor SUI1, putative |
Neospora caninum | NCLIV_014350 | hypothetical protein |
Oryza sativa | 4339216 | Os05g0498400 |
Oryza sativa | 4324136 | Os01g0794500 |
Oryza sativa | 4343445 | Os07g0529800 |
Oryza sativa | 4337078 | Os04g0627900 |
Plasmodium berghei | PBANKA_1456900 | translation initiation factor SUI1, putative |
Plasmodium falciparum | PF3D7_1243600 | translation initiation factor SUI1, putative |
Plasmodium knowlesi | PKNH_1462900 | translation initiation factor SUI1, putative |
Plasmodium vivax | PVX_101080 | translation initiation factor SUI1, putative |
Plasmodium yoelii | PY01209 | translation initiation factor SUI1 |
Saccharomyces cerevisiae | YNL244C | translation initiation factor eIF1 |
Schistosoma japonicum | Sjp_0002810 | ko:K03113 translation initiation factor SUI1, putative |
Schistosoma mansoni | Smp_019440 | translation factor sui1 |
Schmidtea mediterranea | mk4.003342.03 | Protein translation factor SUI1 homolog |
Schmidtea mediterranea | mk4.003685.02 | Protein translation factor SUI1 homolog |
Schmidtea mediterranea | mk4.000849.00 | Protein translation factor SUI1 homolog |
Trypanosoma brucei gambiense | Tbg972.11.6590 | Protein translation factor SUI1 homolog, putative |
Trypanosoma brucei | Tb927.11.5840 | Protein translation factor SUI1 homolog, putative |
Trypanosoma congolense | TcIL3000.11.6240 | Eukaryotic translation initiation factor 1, putative |
Trypanosoma congolense | TcIL3000.11.6220 | Eukaryotic translation initiation factor 1, putative |
Trypanosoma cruzi | TcCLB.508515.20 | Eukaryotic translation initiation factor 1, putative |
Trypanosoma cruzi | TcCLB.508641.184 | Eukaryotic translation initiation factor 1, putative |
Toxoplasma gondii | TGME49_249370 | translation initiation factor SUI1, putative |
Toxoplasma gondii | TGME49_286090 | translation initiation factor SUI1, putative |
Theileria parva | TP04_0142 | protein translation initiation factor SUI1, putative |
Trichomonas vaginalis | TVAG_066940 | translation factor sui1, putative |
Trichomonas vaginalis | TVAG_134990 | translation factor sui1, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.02.3595 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.3595 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.3595 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.02.3595 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_T27F7.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T27F7.3 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_T27F7.3 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_T27F7.3 | Caenorhabditis elegans | slow growth | wormbase |
YNL244C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1456900 | Plasmodium berghei | Essential | plasmo |
TGME49_249370 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_286090 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_249370 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_286090 | Toxoplasma gondii | Essentiality uncertain | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.