Detailed view for TVAG_013450

Basic information

TDR Targets ID: 928588
Trichomonas vaginalis, Periplasmic beta-glucosidase precursor, putative
Source Database / ID: 

pI: 6.6643 | Length (AA): 718 | MW (Da): 79831 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00933   Glycosyl hydrolase family 3 N terminal domain
PF01915   Glycosyl hydrolase family 3 C-terminal domain
PF14310   Fibronectin type III-like domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0004553   hydrolase activity, hydrolyzing O-glycosyl compounds  
GO:0005975   carbohydrate metabolic process  

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129218)

Species Accession Gene Product
Arabidopsis thaliana AT3G47010   glycosyl hydrolase family protein
Arabidopsis thaliana AT3G47040   Glycosyl hydrolase family protein
Arabidopsis thaliana AT5G04885   Glycosyl hydrolase family protein
Arabidopsis thaliana AT3G47000   glycosyl hydrolase family protein
Arabidopsis thaliana AT3G62710   glycosyl hydrolase family protein
Arabidopsis thaliana AT5G20950   glycosyl hydrolase family protein
Arabidopsis thaliana AT3G47050   glycosyl hydrolase family protein
Arabidopsis thaliana AT5G20940   glycosyl hydrolase family protein
Dictyostelium discoideum DDB_G0292810   beta glucosidase
Escherichia coli b2132   beta-D-glucoside glucohydrolase, periplasmic
Oryza sativa 4324619   Os01g0771900
Oryza sativa 4328197   Os02g0131400
Oryza sativa 4334114   Os03g0749300
Oryza sativa 4326722   Os01g0296700
Oryza sativa 4334113   Os03g0749100
Oryza sativa 4334116   Os03g0749500
Trichomonas vaginalis TVAG_013450   Periplasmic beta-glucosidase precursor, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

No enough druggable targets predicted through repurposing network model to make a plot

Putative Drugs List

Compound Raw Global Species
0.0032 0.6015 0.4499

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_013450 (Trichomonas vaginalis), Periplasmic beta-glucosidase precursor, putative
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