pI: 6.4067 |
Length (AA): 534 |
MW (Da): 59837 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_126903)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G28450 | zinc finger CCCH domain-containing protein 24 |
Arabidopsis thaliana | AT3G21300 | RNA methyltransferase family protein |
Brugia malayi | Bm1_52450 | hypothetical protein |
Candida albicans | CaO19.11843 | one of two potential tRNA (Uracil-5-)-methyltransferase genes |
Candida albicans | CaO19.3327 | one of two potential tRNA (Uracil-5-)-methyltransferase genes |
Candida albicans | CaO19.10837 | one of two potential tRNA (Uracil-5-)-methyltransferase genes |
Candida albicans | CaO19.4365 | one of two potential tRNA (Uracil-5-)-methyltransferase genes |
Caenorhabditis elegans | CELE_H24K24.4 | Protein H24K24.4 |
Cryptosporidium hominis | Chro.20288 | hypothetical protein |
Cryptosporidium parvum | cgd2_2710 | TrmA RNA methylase |
Chlamydia trachomatis | CT_742 | rRNA methyltransferse |
Dictyostelium discoideum | DDB_G0293244 | hypothetical protein |
Drosophila melanogaster | Dmel_CG3808 | CG3808 gene product from transcript CG3808-RA |
Escherichia coli | b2785 | 23S rRNA m(5)U1939 methyltransferase, SAM-dependent |
Escherichia coli | b0859 | 23S rRNA m(5)U747 methyltransferase, SAM-dependent |
Echinococcus granulosus | EgrG_001011250 | tRNA uracil 5 methyltransferase A |
Entamoeba histolytica | EHI_047740 | RNA methyltransferase, putative |
Echinococcus multilocularis | EmuJ_001011250 | tRNA (uracil 5) methyltransferase A |
Homo sapiens | ENSG00000188917 | tRNA methyltransferase 2 homolog B (S. cerevisiae) |
Homo sapiens | ENSG00000099899 | tRNA methyltransferase 2 homolog A (S. cerevisiae) |
Leishmania braziliensis | LbrM.20.5870 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_201680.1 | tRNA (Uracil-5-)-methyltransferase, putative |
Leishmania infantum | LinJ.20.1680 | hypothetical protein, conserved |
Leishmania major | LmjF.20.1710 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.20.1710 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_03093 | hypothetical protein |
Loa Loa (eye worm) | LOAG_07527 | hypothetical protein |
Mus musculus | ENSMUSG00000067369 | TRM2 tRNA methyltransferase 2B |
Mus musculus | ENSMUSG00000022721 | TRM2 tRNA methyltransferase 2A |
Mycobacterium tuberculosis | Rv2689c | Conserved alanine and valine and glycine rich protein |
Mycobacterium ulcerans | MUL_3327 | SAM-dependent methyltransferase |
Neospora caninum | NCLIV_035280 | Methyltransferase, related |
Neospora caninum | NCLIV_066290 | hypothetical protein |
Oryza sativa | 9271204 | Os04g0105000 |
Oryza sativa | 4327311 | Os01g0193600 |
Onchocerca volvulus | OVOC6615 |
|
Plasmodium berghei | PBANKA_0914600 | RNA (uracil-5-)methyltransferase, putative |
Plasmodium falciparum | PF3D7_1133800 | RNA (uracil-5-)methyltransferase, putative |
Plasmodium knowlesi | PKNH_0931900 | RNA (uracil-5-)methyltransferase, putative |
Plasmodium vivax | PVX_092300 | hypothetical protein, conserved |
Plasmodium yoelii | PY05313 | unnamed protein product |
Saccharomyces cerevisiae | YKR056W | Trm2p |
Schistosoma mansoni | Smp_123520 | rna m5u methyltransferase |
Schmidtea mediterranea | mk4.071798.02 | |
Schmidtea mediterranea | mk4.071798.01 | |
Schmidtea mediterranea | mk4.010005.04 | tRNA |
Schmidtea mediterranea | mk4.011294.05 | tRNA |
Schmidtea mediterranea | mk4.035241.00 | tRNA |
Trypanosoma brucei gambiense | Tbg972.1.1860 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.1.3050 | tRNA (Uracil-5-)-methyltransferase, putative |
Trypanosoma congolense | TcIL3000_1_1470 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.508405.110 | tRNA (Uracil-5-)-methyltransferase, putative |
Trypanosoma cruzi | TcCLB.506363.130 | tRNA (Uracil-5-)-methyltransferase, putative |
Toxoplasma gondii | TGME49_250750 | tRNA (uracil-5-)-methyltransferase |
Toxoplasma gondii | TGME49_271860 | tRNA (Uracil-5-)-methyltransferase |
Trichomonas vaginalis | TVAG_151750 | RNA m5u methyltransferase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.1.3050 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.1.3050 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.1.3050 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.1.3050 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b0859 | Escherichia coli | non-essential | goodall |
b2785 | Escherichia coli | non-essential | goodall |
PBANKA_0914600 | Plasmodium berghei | Essential | plasmo |
TGME49_250750 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_271860 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_250750 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_271860 | Toxoplasma gondii | Probably non-essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.