Detailed view for Tb11.v5.0525

Basic information

TDR Targets ID: 932430
Trypanosoma brucei, hypothetical protein, conserved
Source Database / ID:  TriTrypDB  GeneDB

pI: 5.6801 | Length (AA): 427 | MW (Da): 48701 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0060271   GO:cilium assembly  

GO:0042073   intraflagellar transport  
GO:0030992   intraflagellar transport particle B  
GO:0015631   tubulin binding  
GO:0003676   nucleic acid binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
NA% percentile Procyclic. Siegel TN
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_130957)

Species Accession Gene Product
Brugia malayi Bm1_16130   hypothetical protein
Caenorhabditis elegans CELE_F32A6.2   Protein IFT-81
Echinococcus granulosus EgrG_000460400   intraflagellar transport protein 81
Echinococcus multilocularis EmuJ_000460400   intraflagellar transport protein 81
Giardia lamblia GL50803_15428   IFT complex B
Homo sapiens ENSG00000122970   intraflagellar transport 81
Leishmania braziliensis LbrM.20.0240   hypothetical protein, conserved
Leishmania donovani LdBPK_340250.1   intraflagellar transport protein 81, putative
Leishmania infantum LinJ.34.0250   hypothetical protein, conserved
Leishmania major LmjF.34.0230   hypothetical protein, conserved
Leishmania mexicana LmxM.33.0230   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_11395   hypothetical protein
Loa Loa (eye worm) LOAG_07809   hypothetical protein
Loa Loa (eye worm) LOAG_07810   hypothetical protein
Mus musculus ENSMUSG00000029469   intraflagellar transport 81
Neospora caninum NCLIV_044040   hypothetical protein, conserved
Schistosoma japonicum Sjp_0096110   Intraflagellar transport protein 81 homolog, putative
Schistosoma japonicum Sjp_0036790   Intraflagellar transport protein 81 homolog, putative
Schistosoma mansoni Smp_139730   Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein)
Schmidtea mediterranea mk4.002012.03   Intraflagellar transport protein 81 homolog
Trypanosoma brucei gambiense Tbg972.10.3290   hypothetical protein, conserved
Trypanosoma brucei Tb927.10.2640   intraflagellar transport protein 81
Trypanosoma brucei Tb11.v5.0525   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_10_2260   intraflagellar transport protein 81, putative
Trypanosoma cruzi TcCLB.506195.190   intraflagellar transport protein 81, putative
Trypanosoma cruzi TcCLB.506407.80   intraflagellar transport protein 81, putative
Toxoplasma gondii TGME49_305570   intraflagellar transport protein IFT81
Trichomonas vaginalis TVAG_009330   myosin heavy chain, clone, putative

Essentiality

Tb11.v5.0525 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.2640 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.2640 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.2640 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.2640 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_305570 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Tb11.v5.0525 (Trypanosoma brucei), hypothetical protein, conserved
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