Detailed view for CT_777

Basic information

TDR Targets ID: 934830
Chlamydia trachomatis, 8-amino-7-oxononanoate synthase
Source Database / ID:  KEGG  

pI: 6.4961 | Length (AA): 377 | MW (Da): 41470 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00155   Aminotransferase class I and II

Gene Ontology

Mouse over links to read term descriptions.
GO:0030170   pyridoxal phosphate binding  
GO:0003824   catalytic activity  
GO:0009058   biosynthetic process  

Metabolic Pathways

Biotin metabolism (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 356 3tqx (A) 39 396 18.00 0.017 1 1.10749 0.21
7 344 1bs0 (A) 42 380 31.00 0 1 1.25695 -0.38
7 345 3a2b (A) 47 387 22.00 0 1 1.1794 -0.57
11 226 5txr (B) 120 327 33.00 0 1 0.902344 0.43
12 267 2bwn (A) 54 304 29.00 0 1 1.02145 -0.6

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127265)

Species Accession Gene Product
Arabidopsis thaliana AT3G48780   serine palmitoyltransferase 1
Arabidopsis thaliana AT5G23670   serine palmitoyltransferase subunit LCB2
Brugia malayi Bm1_20560   hypothetical protein
Candida albicans CaO19.12494   putative ser palmitoyltransferase component
Candida albicans CaO19.5027   putative ser palmitoyltransferase component
Caenorhabditis elegans CELE_F43H9.2   Protein SPTL-2, isoform A
Caenorhabditis elegans CELE_T22G5.5   Protein SPTL-3, isoform A
Chlamydia trachomatis CT_777   8-amino-7-oxononanoate synthase
Dictyostelium discoideum DDB_G0291283   serine C-palmitoyltransferase subunit
Drosophila melanogaster Dmel_CG4162   CG4162 gene product from transcript CG4162-RA
Echinococcus granulosus EgrG_000374100   serine palmitoyltransferase long chain base
Entamoeba histolytica EHI_069310   serine palmitoyltransferase, putative
Entamoeba histolytica EHI_152280   serine palmitoyltransferase, putative
Echinococcus multilocularis EmuJ_000374100   serine palmitoyltransferase, long chain base
Giardia lamblia GL50803_14374   Serine palmitoyltransferase 2
Homo sapiens ENSG00000100596   serine palmitoyltransferase, long chain base subunit 2
Homo sapiens 55304   serine palmitoyltransferase, long chain base subunit 3
Leishmania braziliensis LbrM.34.0360   serine palmitoyltransferase, putative
Leishmania donovani LdBPK_350320.1   serine palmitoyltransferase, putative
Leishmania infantum LinJ.35.0320   serine palmitoyltransferase, putative
Leishmania major LmjF.35.0320   serine palmitoyltransferase, putative
Leishmania mexicana LmxM.34.0320   serine palmitoyltransferase, putative
Loa Loa (eye worm) LOAG_04432   hypothetical protein
Mus musculus ENSMUSG00000039092   serine palmitoyltransferase, long chain base subunit 3
Mus musculus 20773   serine palmitoyltransferase, long chain base subunit 2
Neospora caninum NCLIV_042850   Pyridoxal phosphate-dependent acyltransferase (EC 2.3.1.29), related
Neospora caninum NCLIV_042840   hypothetical protein
Oryza sativa 4350591   Os11g0516000
Oryza sativa 4326964   Os01g0928600
Oryza sativa 4326966   Os01g0928800
Oryza sativa 4326965   Os01g0928700
Plasmodium berghei PBANKA_1027000   serine C-palmitoyltransferase, putative
Plasmodium falciparum PF3D7_1415700   serine C-palmitoyltransferase, putative
Plasmodium knowlesi PKNH_1342400   serine C-palmitoyltransferase, putative
Plasmodium vivax PVX_085665   serine C-palmitoyltransferase, putative
Plasmodium yoelii PY00385   probable glycine C-acetyltransferase, putative
Saccharomyces cerevisiae YDR062W   serine C-palmitoyltransferase LCB2
Schistosoma japonicum Sjp_0206200   Serine palmitoyltransferase 2, putative
Schistosoma japonicum Sjp_0072130   ko:K00654 serine palmitoyltransferase [EC2.3.1.50], putative
Schistosoma mansoni Smp_079380   serine palmitoyltransferase 2
Schmidtea mediterranea mk4.011243.00   Serine palmitoyltransferase 2
Schmidtea mediterranea mk4.010976.00   Serine palmitoyltransferase 2
Schmidtea mediterranea mk4.008649.01  
Schmidtea mediterranea mk4.012600.00  
Schmidtea mediterranea mk4.009972.00   Serine palmitoyltransferase 2
Schmidtea mediterranea mk4.021494.00   Serine palmitoyltransferase 2
Schmidtea mediterranea mk4.006691.04   Serine palmitoyltransferase 2
Trypanosoma brucei gambiense Tbg972.10.5050   serine palmitoyltransferase, putative
Trypanosoma brucei Tb927.10.4050   serine palmitoyltransferase, putative
Trypanosoma brucei Tb11.v5.0649   serine palmitoyltransferase, putative
Trypanosoma congolense TcIL3000_10_3380   serine palmitoyltransferase, putative
Trypanosoma cruzi TcCLB.503453.100   serine palmitoyltransferase, putative
Trypanosoma cruzi TcCLB.506959.70   serine palmitoyltransferase, putative
Toxoplasma gondii TGME49_290980   glycine C-acetyltransferase, putative
Toxoplasma gondii TGME49_290970   8-amino-7-oxononanoate synthase
Trichomonas vaginalis TVAG_388650   serine palmitoyltransferase I, putative

Essentiality

CT_777 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.4050 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.4050 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.4050 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.4050 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
YDR062W Saccharomyces cerevisiae inviable yeastgenome
TGME49_290970 Toxoplasma gondii Essentiality uncertain sidik
TGME49_290980 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens serine palmitoyltransferase, long chain base subunit 2 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier CT_777 (Chlamydia trachomatis), 8-amino-7-oxononanoate synthase
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