Detailed view for LOAG_07123

Basic information

TDR Targets ID: 935489
Loa Loa (eye worm), dCMP deaminase
Source Database / ID:  KEGG  

pI: 8.2262 | Length (AA): 206 | MW (Da): 22855 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00383   Cytidine and deoxycytidylate deaminase zinc-binding region

Gene Ontology

Mouse over links to read term descriptions.
GO:0006220   pyrimidine nucleotide metabolic process  
GO:0004132   dCMP deaminase activity  
GO:0016787   hydrolase activity  
GO:0008270   zinc ion binding  
GO:0003824   catalytic activity  

Metabolic Pathways

Pyrimidine metabolism (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
38 197 2w4l (A) 7 168 56.00 0 1 1.4427 -0.44
124 191 3vgj (A) 171 226 41.00 0.94 0.12 -0.0298029 1.94

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128503)

Species Accession Gene Product
Arabidopsis thaliana AT3G48540   cytidine/deoxycytidylate deaminase family protein
Brugia malayi Bm1_28380   dCMP deaminase
Candida albicans CaO19.7243   dCMP deaminase
Caenorhabditis elegans CELE_ZK643.2   Protein ZK643.2
Cryptosporidium hominis Chro.20294   dCMP deaminase; Dcd1p
Cryptosporidium parvum cgd2_2780   dCMP deaminase, Dcd1p like
Drosophila melanogaster Dmel_CG6951   CG6951 gene product from transcript CG6951-RB
Echinococcus granulosus EgrG_000427100   deoxycytidylate deaminase
Echinococcus multilocularis EmuJ_000427100   deoxycytidylate deaminase
Homo sapiens ENSG00000129187   dCMP deaminase
Loa Loa (eye worm) LOAG_07123   dCMP deaminase
Mus musculus ENSMUSG00000031562   dCMP deaminase
Neospora caninum NCLIV_038260   hypothetical protein
Oryza sativa 4326895   Os01g0765000
Onchocerca volvulus OVOC1340   Putative deoxycytidylate deaminase
Saccharomyces cerevisiae YHR144C   Dcd1p
Schistosoma japonicum Sjp_0066070   ko:K01493 dCMP deaminase [EC3.5.4.12], putative
Schistosoma mansoni Smp_009530   deoxycytidylate deaminase
Schmidtea mediterranea mk4.002987.02   Deoxycytidylate deaminase
Treponema pallidum TP0274   deoxycytidylate deaminase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_07123 (Loa Loa (eye worm)), dCMP deaminase
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