Detailed view for LOAG_05194

Basic information

TDR Targets ID: 936264
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 5.3611 | Length (AA): 1018 | MW (Da): 116365 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00431   CUB domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 11 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
79 206 1spp (B) 7 109 21.00 0 0.53 0.157637 -0.22
80 206 2wno (A) 134 246 29.00 0 0.57 0.414654 -0.76
81 586 3kq4 (B) 932 1386 28.00 0 1 0.588653 0.96
81 133 5fwu (A) 214 266 37.00 0.071 0.15 0.244663 1
86 461 4aqb (A) 25 297 30.00 0 1 0.190952 1.66
340 456 2wno (A) 134 242 37.00 0.0000000000069 1 0.528531 -0.26
340 586 4gz9 (A) 26 262 34.00 0 1 0.523233 0.57
341 460 5fws (A) 214 320 33.00 0.000011 1 0.472478 -0.57
726 757 4los (A) 159 188 47.00 0 0.3 0.455334 -0.04
889 1018 1szb (A) 5 129 18.00 0.06 0.35 0.300601 -0.39
904 1013 2wno (A) 151 249 21.00 0.0023 0.13 0.259955 -0.7

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133495)

Species Accession Gene Product
Brugia malayi Bm1_50955   Calcium binding EGF domain containing protein
Caenorhabditis elegans CELE_ZC116.3   Protein ZC116.3
Drosophila melanogaster Dmel_CG32702   Cubilin ortholog
Drosophila melanogaster Dmel_CG42255   CG42255 gene product from transcript CG42255-RB
Homo sapiens ENSG00000107611   cubilin (intrinsic factor-cobalamin receptor)
Loa Loa (eye worm) LOAG_01531   hypothetical protein
Loa Loa (eye worm) LOAG_05194   hypothetical protein
Mus musculus ENSMUSG00000026726   cubilin (intrinsic factor-cobalamin receptor)
Onchocerca volvulus OVOC12725  
Onchocerca volvulus OVOC7004   Putative cubilin
Schmidtea mediterranea mk4.000344.11  
Schmidtea mediterranea mk4.001438.04  
Schmidtea mediterranea mk4.001438.03  

Essentiality

LOAG_05194 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_ZC116.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_ZC116.3 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0124 0.3617 0.3617
0.0139 0.3164 0.3164
0.0034 0.3155 0.2842
0.0152 0.3381 0.3381

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_05194 (Loa Loa (eye worm)), hypothetical protein
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