Detailed view for LOAG_03780

Basic information

TDR Targets ID: 936295
Loa Loa (eye worm), aminopeptidase in chromosome V
Source Database / ID:  KEGG  

pI: 7.5006 | Length (AA): 513 | MW (Da): 56266 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00883   Cytosol aminopeptidase family, catalytic domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005737   cytoplasm  
GO:0005622   intracellular  
GO:0004177   aminopeptidase activity  
GO:0030145   manganese ion binding  
GO:0008235   metalloexopeptidase activity  
GO:0019538   protein metabolic process  
GO:0006508   proteolysis  

Metabolic Pathways

Glutathione metabolism (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
17 503 4ksi (A) 75 568 20.00 0 1 1.05422 0.39
28 512 1lam (A) 3 482 19.00 0 0.97 1.10552 0.26
49 88 2yrp (A) 8 47 38.00 0.18 0.14 0.313173 1.5
163 374 5nsk (A) 200 404 31.00 0.000000000014 0.96 0.666455 -0.26

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_135573)

Species Accession Gene Product
Brugia malayi Bm1_50530   Aminopeptidase W07G4.4 in chromosome V
Caenorhabditis elegans CELE_W07G4.4   Protein LAP-2
Drosophila melanogaster Dmel_CG9285   Dipeptidase B
Echinococcus granulosus EgrG_001024000   dedicator of cytokinesis protein 1
Echinococcus granulosus EgrG_000855000   leucyl aminopeptidase
Echinococcus granulosus EgrG_000989250   hypothetical protein
Echinococcus granulosus EgrG_001031700   leucyl aminopeptidase
Echinococcus multilocularis EmuJ_000989250  
Echinococcus multilocularis EmuJ_000855000   leucyl aminopeptidase
Echinococcus multilocularis EmuJ_001031700   leucyl aminopeptidase
Echinococcus multilocularis EmuJ_000374300   leucyl aminopeptidase
Echinococcus multilocularis EmuJ_001024000   dedicator of cytokinesis protein 1
Loa Loa (eye worm) LOAG_03780   aminopeptidase in chromosome V
Schistosoma japonicum Sjp_0204550   ko:K01255 leucyl aminopeptidase [EC3.4.11.1], putative
Schistosoma japonicum Sjp_0025500   ko:K05727 dedicator of cytokinesis 1/2/3/4/5, putative
Schistosoma mansoni Smp_029990   dedicator of cytokinesis protein 1 (DOCK1)
Schistosoma mansoni Smp_030000   leucine aminopeptidase
Schmidtea mediterranea mk4.007370.01   Dipeptidase B
Schmidtea mediterranea mk4.000819.06   Dipeptidase B
Schmidtea mediterranea mk4.009563.00   Dipeptidase B
Schmidtea mediterranea mk4.000015.05   Putative dedicator of cytokinesis protein 1
Schmidtea mediterranea mk4.012478.00   Dipeptidase B

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_03780 (Loa Loa (eye worm)), aminopeptidase in chromosome V
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