Detailed view for LOAG_11834

Basic information

TDR Targets ID: 936399
Loa Loa (eye worm), Erv1/Alr family protein
Source Database / ID:  KEGG  

pI: 8.7567 | Length (AA): 583 | MW (Da): 67870 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00085   Thioredoxin
PF04777   Erv1 / Alr family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016972   thiol oxidase activity  
GO:0055114   oxidation reduction  
GO:0045454   cell redox homeostasis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 152 2b5e (A) 342 482 22.00 0.0000022 0.77 0.478559 0.19
37 566 4p2l (A) 40 541 25.00 0 1 1.09279 0.23
40 548 4p2l (A) 43 518 28.00 0 1 1.11487 0.06
41 152 3h79 (A) 16 125 19.00 0 0.92 0.55301 -1.24
52 121 2dj1 (A) 28 95 35.00 0.00000084 0.98 0.456869 0.79
57 89 4i8b (A) 21 52 47.00 0.12 0.24 0.313404 1.95

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129038)

Species Accession Gene Product
Arabidopsis thaliana AT1G15020   quiescin-sulfhydryl oxidase 1
Arabidopsis thaliana AT2G01270   quiescin-sulfhydryl oxidase 2
Brugia malayi Bm1_36435   Erv1 / Alr family protein
Caenorhabditis elegans CELE_F47B7.2   Protein F47B7.2, isoform B
Caenorhabditis elegans CELE_T10H10.2   Protein T10H10.2
Caenorhabditis elegans CELE_F35G2.1   Protein F35G2.1, isoform B
Drosophila melanogaster Dmel_CG17843   CG17843 gene product from transcript CG17843-RA
Drosophila melanogaster Dmel_CG6690   CG6690 gene product from transcript CG6690-RA
Drosophila melanogaster Dmel_CG4670   CG4670 gene product from transcript CG4670-RB
Drosophila melanogaster Dmel_CG31413   CG31413 gene product from transcript CG31413-RA
Echinococcus granulosus EgrG_000245600   sulfhydryl oxidase 1
Echinococcus multilocularis EmuJ_000245600   sulfhydryl oxidase 1
Homo sapiens ENSG00000165661   quiescin Q6 sulfhydryl oxidase 2
Homo sapiens ENSG00000116260   quiescin Q6 sulfhydryl oxidase 1
Leishmania braziliensis LbrM.30.0510   quiescin sulfhydryl oxidase, putative
Leishmania donovani LdBPK_300440.1   quiescin sulfhydryl oxidase, putative
Leishmania infantum LinJ.30.0440   quiescin sulfhydryl oxidase, putative
Leishmania mexicana LmxM.29.0430   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_00988   hypothetical protein
Loa Loa (eye worm) LOAG_11834   Erv1/Alr family protein
Loa Loa (eye worm) LOAG_11291   hypothetical protein
Mus musculus ENSMUSG00000033684   quiescin Q6 sulfhydryl oxidase 1
Mus musculus ENSMUSG00000036327   quiescin Q6 sulfhydryl oxidase 2
Oryza sativa 4339541   Os05g0552500
Onchocerca volvulus OVOC2134   Sulfhydryl oxidase homolog
Onchocerca volvulus OVOC4629   Sulfhydryl oxidase homolog
Onchocerca volvulus OVOC3401   Sulfhydryl oxidase homolog
Schistosoma japonicum Sjp_0038080   ko:K10758 thiol oxidase [EC1.8.3.2], putative
Schistosoma mansoni Smp_098710   quiescin q6-related sulfhydryl oxidase
Schmidtea mediterranea mk4.027261.00  
Schmidtea mediterranea mk4.018305.00  
Trypanosoma brucei gambiense Tbg972.6.1550   hypothetical protein, conserved
Trypanosoma brucei Tb927.6.1850   quiescin sulfhydryl oxidase
Trypanosoma congolense TcIL3000_0_58190   quiescin sulfhydryl oxidase
Trypanosoma congolense TcIL3000_6_1440   quiescin sulfhydryl oxidase
Trypanosoma cruzi TcCLB.511491.170   quiescin sulfhydryl oxidase, putative
Trypanosoma cruzi TcCLB.511493.10   quiescin sulfhydryl oxidase, putative

Essentiality

LOAG_11834 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.6.1850 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.6.1850 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.6.1850 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.6.1850 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F47B7.2 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_11834 (Loa Loa (eye worm)), Erv1/Alr family protein
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