Detailed view for LOAG_08473

Basic information

TDR Targets ID: 936487
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 9.3732 | Length (AA): 352 | MW (Da): 39435 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00081   Iron/manganese superoxide dismutases, alpha-hairpin domain
PF00361   Proton-conducting membrane transporter
PF02777   Iron/manganese superoxide dismutases, C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0046872   metal ion binding  
GO:0004784   superoxide dismutase activity  
GO:0055114   oxidation reduction  
GO:0006801   superoxide metabolic process  

Metabolic Pathways

FoxO signaling pathway (KEGG)
Peroxisome (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
154 352 3dc6 (A) 1 197 63.00 0 1 1.45634 -1.76
311 352 1coj (A) 161 202 50.00 0.00000036 0.74 0.588818 0.71

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126676)

Species Accession Gene Product
Arabidopsis thaliana AT5G23310   Fe superoxide dismutase 3
Arabidopsis thaliana AT4G25100   superoxide dismutase [Fe]
Arabidopsis thaliana AT3G56350   Iron/manganese superoxide dismutase family protein
Arabidopsis thaliana AT5G51100   Fe superoxide dismutase 2
Arabidopsis thaliana AT3G10920   Superoxide dismutase [Mn]
Babesia bovis BBOV_IV011480   superoxide dismutase, putative
Brugia malayi Bm1_48045   Superoxide dismutase, mitochondrial precursor, putative
Candida albicans CaO19.3340   likely mitochondrial manganese-containing superoxide dismutase similar to S. cerevisiae SOD2 (YHR008C)
Candida albicans CaJ7_0018   hypothetical protein
Candida albicans CaO19.10848   likely mitochondrial manganese-containing superoxide dismutase similar to S. cerevisiae SOD2 (YHR008C)
Caenorhabditis elegans CELE_F10D11.1   Protein SOD-2
Caenorhabditis elegans CELE_C08A9.1   Protein SOD-3
Cryptosporidium hominis Chro.50049   superoxide dismutase
Cryptosporidium parvum cgd5_3230   superoxide dismutase
Chlamydia trachomatis CT_294   superoxide dismutase
Dictyostelium discoideum DDB_G0271106   superoxide dismutase
Drosophila melanogaster Dmel_CG8905   Superoxide dismutase 2 (Mn)
Escherichia coli b1656   superoxide dismutase, Fe
Escherichia coli b3908   superoxide dismutase, Mn
Echinococcus granulosus EgrG_000607900   manganese superoxide dismutase
Entamoeba histolytica EHI_159160   iron-containing superoxide dismutase
Echinococcus multilocularis EmuJ_000607900   manganese superoxide dismutase
Homo sapiens ENSG00000112096   superoxide dismutase 2, mitochondrial
Leishmania braziliensis LbrM.32.2010   iron superoxide dismutase, putative
Leishmania braziliensis LbrM.32.2000   iron superoxide dismutase, putative
Leishmania braziliensis LbrM.08.0330   iron superoxide dismutase
Leishmania donovani LdBPK_321920.1   iron superoxide dismutase, putative
Leishmania donovani LdBPK_321910.1   iron superoxide dismutase, putative
Leishmania donovani LdBPK_080300.1   iron superoxide dismutase A, mitochondrial
Leishmania infantum LinJ.32.1920   iron superoxide dismutase, putative
Leishmania infantum LinJ.08.0300   iron superoxide dismutase
Leishmania infantum LinJ.32.1910   iron superoxide dismutase, putative
Leishmania major LmjF.08.0290   iron superoxide dismutase
Leishmania major LmjF.32.1830   iron superoxide dismutase, putative
Leishmania major LmjF.32.1820   iron superoxide dismutase, putative
Leishmania mexicana LmxM.08.0290   iron superoxide dismutase
Leishmania mexicana LmxM.31.1830   iron superoxide dismutase, putative
Leishmania mexicana LmxM.31.1820   iron superoxide dismutase, putative
Loa Loa (eye worm) LOAG_08473   hypothetical protein
Mycobacterium leprae ML0072c   Probable superoxide dismutase SodA
Mus musculus ENSMUSG00000006818   superoxide dismutase 2, mitochondrial
Mycobacterium tuberculosis Rv3846   Superoxide dismutase [FE] SodA
Mycobacterium ulcerans MUL_5018   superoxide dismutase [Fe] SodA
Neospora caninum NCLIV_058710   Superoxide dismutase (EC 1.15.1.1), related
Neospora caninum NCLIV_058810   superoxide dismutase
Neospora caninum NCLIV_058830   Superoxide dismutase (EC 1.15.1.1), related
Oryza sativa 4338417   Os05g0323900
Oryza sativa 4340091   Os06g0143000
Oryza sativa 4339922   Os06g0115400
Onchocerca volvulus OVOC1096c   Superoxide dismutase [Mn], mitochondrial homolog
Onchocerca volvulus OVOC1096a   Superoxide dismutase [Mn], mitochondrial homolog
Onchocerca volvulus OVOC1096b   Superoxide dismutase [Mn], mitochondrial homolog
Plasmodium berghei PBANKA_1422700   superoxide dismutase [Fe], putative
Plasmodium falciparum PF3D7_0814900   superoxide dismutase [Fe]
Plasmodium knowlesi PKNH_1425400   superoxide dismutase [Fe], putative
Plasmodium vivax PVX_123030   superoxide dismutase [Fe], putative
Plasmodium yoelii PY05422   Iron/manganese superoxide dismutases, putative
Saccharomyces cerevisiae YHR008C   superoxide dismutase SOD2
Schistosoma japonicum Sjp_0214230   ko:K04564 superoxide dismutase, Fe-Mn family [EC1.15.1.1A], putative
Schistosoma mansoni Smp_056440   superoxide dismutase [mn]
Schmidtea mediterranea mk4.041439.00  
Schmidtea mediterranea mk4.000687.06   Superoxide dismutase
Schmidtea mediterranea mk4.058631.01  
Schmidtea mediterranea mk4.000571.02   Superoxide dismutase
Trypanosoma brucei gambiense Tbg972.11.17840   iron superoxide dismutase, putative
Trypanosoma brucei gambiense Tbg972.5.4710   iron superoxide dismutase, putative
Trypanosoma brucei gambiense Tbg972.11.16860   iron superoxide dismutase, putative
Trypanosoma brucei Tb927.11.15910   iron superoxide dismutase
Trypanosoma brucei Tb927.5.3350   iron superoxide dismutase A, mitochondrial
Trypanosoma brucei Tb927.11.15020   iron superoxide dismutase
Trypanosoma congolense TcIL3000.11.15820   iron superoxide dismutase
Trypanosoma congolense TcIL3000_5_3750   iron superoxide dismutase A, mitochondrial
Trypanosoma congolense TcIL3000.11.15220   iron superoxide dismutase
Trypanosoma cruzi TcCLB.509775.40   iron superoxide dismutase A, mitochondrial
Trypanosoma cruzi TcCLB.508445.20   iron superoxide dismutase, putative
Trypanosoma cruzi TcCLB.507061.30   iron superoxide dismutase A, mitochondrial
Trypanosoma cruzi TcCLB.511019.90   iron superoxide dismutase, putative
Trypanosoma cruzi TcCLB.507039.10   iron superoxide dismutase, putative
Trypanosoma cruzi TcCLB.511715.10   iron superoxide dismutase, putative
Toxoplasma gondii TGME49_316190   superoxide dismutase SOD3
Toxoplasma gondii TGME49_316330   superoxide dismutase SOD2
Toxoplasma gondii TGME49_316310   superoxide dismutase
Theileria parva TP01_1156   iron-dependent superoxide dismutase, putative
Trichomonas vaginalis TVAG_079600   superoxide dismutase [fe], putative
Trichomonas vaginalis TVAG_039980   superoxide dismutase, putative
Trichomonas vaginalis TVAG_404200   superoxide dismutase, putative
Trichomonas vaginalis TVAG_161300   iron superoxide dismutase A, putative
Trichomonas vaginalis TVAG_120340   superoxide dismutase [mn], putative
Trichomonas vaginalis TVAG_049140   superoxide dismutase [fe], putative
Trichomonas vaginalis TVAG_337230   superoxide dismutase [fe], putative
Wolbachia endosymbiont of Brugia malayi Wbm0220   superoxide dismutase, SodA

Essentiality

LOAG_08473 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.6660 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.6660 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.6660 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.01.6660 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb11.01.7550 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.7550 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.7550 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.01.7550 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.5.3350 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.5.3350 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.5.3350 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.5.3350 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
b1656 Escherichia coli non-essential goodall
b3908 Escherichia coli non-essential goodall
CELE_C08A9.1 Caenorhabditis elegans larval arrest wormbase
PBANKA_1422700 Plasmodium berghei Slow plasmo
TGME49_316330 Toxoplasma gondii Probably non-essential sidik
TGME49_316190 Toxoplasma gondii Probably non-essential sidik
TGME49_316310 Toxoplasma gondii Probably non-essential sidik
TGME49_316330 Toxoplasma gondii Probably essential sidik
TGME49_316190 Toxoplasma gondii Probably essential sidik
TGME49_316310 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Plasmodium falciparum superoxide dismutase [Fe] Compounds References
Leishmania major iron superoxide dismutase, putative Compounds References
Leishmania major iron superoxide dismutase, putative Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_08473 (Loa Loa (eye worm)), hypothetical protein
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