Detailed view for LOAG_09629

Basic information

TDR Targets ID: 936720
Loa Loa (eye worm), hypothetical protein

Source Database / ID:  KEGG  

pI: 5.9312 | Length (AA): 374 | MW (Da): 40982 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00107   Zinc-binding dehydrogenase
PF16884   N-terminal domain of oxidoreductase

Gene Ontology

Mouse over links to read term descriptions.
GO:0047522   15-oxoprostaglandin 13-oxidase activity  
GO:0006693   prostaglandin metabolic process  
GO:0016491   oxidoreductase activity  
GO:0055114   oxidation reduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
21 374 2j3h (A) 1 345 29.00 0 1 1.26842 0.07
24 374 2zb4 (A) 3 348 47.00 0 1 1.5763 -0.9
25 369 2zb3 (A) 4 343 48.00 0 1 1.55906 -0.82
160 285 4oki (A) 676 798 24.00 0.49 1 0.729498 -0.98

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127214)

Species Accession Gene Product
Arabidopsis thaliana AT5G16960   zinc-binding dehydrogenase family protein
Arabidopsis thaliana AT1G65560   zinc-binding dehydrogenase family protein
Arabidopsis thaliana AT5G37940   zinc-binding dehydrogenase family protein
Arabidopsis thaliana AT5G38000   zinc-binding dehydrogenase family protein
Arabidopsis thaliana AT3G59845   zinc-binding dehydrogenase family protein
Arabidopsis thaliana AT1G26320   zinc-binding dehydrogenase family protein
Arabidopsis thaliana AT5G16980   zinc-binding dehydrogenase family protein
Arabidopsis thaliana AT5G16970   2-alkenal reductase
Arabidopsis thaliana AT5G16990   zinc-binding dehydrogenase family protein
Arabidopsis thaliana AT5G37980   zinc-binding dehydrogenase family protein
Arabidopsis thaliana AT5G17000   zinc-binding dehydrogenase family protein
Arabidopsis thaliana AT3G03080   zinc-binding dehydrogenase family protein
Brugia malayi Bm1_05625   oxidoreductase, zinc-binding dehydrogenase family protein
Candida albicans CaO19.11028   one of two genes similar to S. cerevisiae YML131W, a potential zinc-binding oxidoreductase induced during response to oxidative
Candida albicans CaO19.3544   one of two genes similar to S. cerevisiae YML131W, a potential zinc-binding oxidoreductase induced during response to oxidative
Candida albicans CaO19.10651   one of two genes similar to S. cerevisiae YML131W, a potential zinc-binding oxidoreductase induced during response to oxidative
Candida albicans CaO19.3139   one of two genes similar to S. cerevisiae YML131W, a potential zinc-binding oxidoreductase induced during response to oxidative
Caenorhabditis elegans CELE_M106.3   Protein M106.3, isoform B
Dictyostelium discoideum DDB_G0286309   zinc-containing alcohol dehydrogenase
Dictyostelium discoideum DDB_G0286305   zinc-containing alcohol dehydrogenase
Escherichia coli b1449   curcumin/dihydrocurcumin reductase, NADPH-dependent
Homo sapiens ENSG00000140043   prostaglandin reductase 2
Homo sapiens ENSG00000106853   prostaglandin reductase 1
Loa Loa (eye worm) LOAG_09629   hypothetical protein
Mus musculus ENSMUSG00000072946   prostaglandin reductase 2
Mus musculus ensembl-mmu:ENSMUSG00000028378   prostaglandin reductase 1
Mycobacterium ulcerans MUL_3472   NADP-dependent oxidoreductase
Oryza sativa 4351817   Os12g0226700
Oryza sativa 4336283   Os04g0497000
Oryza sativa 4324916   Os01g0891300
Oryza sativa 4350217   Os11g0255500
Oryza sativa 4351814   Os12g0225900
Oryza sativa 4351818   Os12g0226900
Oryza sativa 4351819   Os12g0227400
Onchocerca volvulus OVOC12428  
Saccharomyces cerevisiae YML131W   hypothetical protein

Essentiality

LOAG_09629 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b1449 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus NADP-dependent leukotriene B4 12-hydroxydehydrogenase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot

No enough druggable targets predicted through repurposing network model to make a plot

Putative Drugs List


Compound Raw Global Species
0.0093 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_09629 (Loa Loa (eye worm)), hypothetical protein
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