Detailed view for LOAG_07622

Basic information

TDR Targets ID: 937228
Loa Loa (eye worm), TKL/IRAK protein kinase
Source Database / ID:  KEGG  

pI: 7.8675 | Length (AA): 436 | MW (Da): 49444 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 90 1d2z (B) 28 146 22.00 0.0011 0.99 0.240248 -1.3
10 96 1d2z (A) 34 121 31.00 0.038 1 0.589141 -0.84
159 425 3rhk (B) 1052 1308 23.00 0 1 0.754985 0.22
184 349 3cok (A) 4 193 24.00 0 0.86 0.586334 0.09
194 399 4ow8 (A) 16 216 26.00 0 1 0.779477 -0.43
296 349 3vut (A) 208 291 44.00 0.0038 0.63 0.490453 0.82

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133246)

Species Accession Gene Product
Arabidopsis thaliana AT1G17250   receptor like protein 3
Arabidopsis thaliana AT5G53890   phytosylfokine-alpha receptor 2
Arabidopsis thaliana AT1G17240   receptor like protein 2
Arabidopsis thaliana AT1G72300   tyrosine-sulfated glycopeptide receptor 1
Arabidopsis thaliana AT2G02220   phytosulfokin receptor 1
Brugia malayi Bm1_38375   FMRFamide related peptide family protein
Loa Loa (eye worm) LOAG_07622   TKL/IRAK protein kinase
Oryza sativa 4328336   Os02g0153400
Oryza sativa 9268287   Os02g0155700
Oryza sativa 9266791   Os02g0153500
Oryza sativa 4341912   Os06g0692600
Oryza sativa 4341910   Os06g0691800
Oryza sativa 4328345   Os02g0154700
Oryza sativa 4342205   Os07g0107800
Oryza sativa 4328081   Os02g0116700
Oryza sativa 4328342   Os02g0154200
Oryza sativa 4328351   Os02g0156400
Oryza sativa 4328333   Os02g0153100
Oryza sativa 4328358   Os02g0157200
Oryza sativa 4328338   Os02g0153700
Oryza sativa 4337364   Os04g0672100
Oryza sativa 4328334   Os02g0153200
Oryza sativa 4341911   Os06g0692100
Oryza sativa 4341913   Os06g0692700
Oryza sativa 4337367   Os04g0672600
Oryza sativa 4330050   Os02g0629400
Oryza sativa 4328348   Os02g0155400
Oryza sativa 4328340   Os02g0154000
Oryza sativa 4328354   Os02g0156800
Oryza sativa 4328339   Os02g0153900

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bos taurus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 21.5% 302 aa Compounds References
Rattus norvegicus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 21.9% 302 aa Compounds References
Oryctolagus cuniculus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 20.5% 302 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0098 0.3242 0.3017
0.0012 0.5 0.5
0.0032 0.5 0.5
0.0007 0.5 0.5
0.0011 1 1
0.0008 0.5 0.5
0.0081 0.5 0.5
0.0004 0.5 0.5
0.0062 0.6935 0.6935
0.0022 0.5 0.5
0.0063 0.7244 0.6686
0.0063 1 1
0.0018 0.5 0.5
0.0064 0.3377 0.3377
0.0059 1 1
0.0039 0.5 0.5
0.0093 0.8828 0.8828
0.0042 0.5 0.5
0.0067 0.5 0.5
0.0012 0.5 0.5
0.0088 0.4477 0.4477
0.0016 0.5 0.5
0.0039 0.9485 1
0.0032 0.5 0.5
0.0069 0.3067 0.9179
0.0066 0.3101 0.3068
0.0026 0.5 0.5
0.0091 1 1
0.0012 0.5 0.5
0.0081 1 1
0.0036 0.5 0.5
0.0092 1 1
0.0059 1 1
0.0059 1 1
0.0033 0.5 0.5
0.0007 0.5 0.5
0.0039 0.5 0.5
0.0056 1 1
0.0023 0.5 0.5
0.0037 1 0.5
0.0029 0.5 0.5
0.0003 0.5 0.5
0.0016 0.5 0.5
0.0027 1 1
0.0007 0.5 0.5
0.0033 1 1
0.0061 0.6883 0.6883

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_07622 (Loa Loa (eye worm)), TKL/IRAK protein kinase
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