Detailed view for LOAG_03753

Basic information

TDR Targets ID: 937451
Loa Loa (eye worm), small heat shock protein
Source Database / ID:  KEGG  

pI: 6.6431 | Length (AA): 113 | MW (Da): 13078 | Paralog Number: 4

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00011   Hsp20/alpha crystallin family

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 113 4ydz (A) 18 128 29.00 0.00000019 1 1.3287 -0.55
7 111 5ltw (C) 6 148 34.00 0 1 1.4121 -0.72
26 113 3n3e (A) 61 148 39.00 0.000000000055 1 1.39086 -1.33

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128990)

Species Accession Gene Product
Brugia malayi Bm1_18780   Hsp20/alpha crystallin family protein
Brugia malayi Bm1_45635   small heat shock protein 12.6, identical
Brugia malayi Bm1_14535   Small heat shock protein OV25-1
Brugia malayi Bm1_03745   Hsp20/alpha crystallin family protein
Brugia malayi Bm1_56065   small heat shock protein - nematode
Brugia malayi Bm1_30385   Hsp20/alpha crystallin family protein
Brugia malayi Bm1_30390   Hsp20/alpha crystallin family protein
Caenorhabditis elegans CELE_C14B9.1   Protein HSP-12.2
Caenorhabditis elegans CELE_T27E4.2   Protein HSP-16.11
Caenorhabditis elegans CELE_F08H9.4   Protein F08H9.4
Caenorhabditis elegans CELE_T27E4.8   Protein HSP-16.1
Caenorhabditis elegans CELE_Y46H3A.3   Protein HSP-16.2
Drosophila melanogaster Dmel_CG4183   Heat shock protein 26
Drosophila melanogaster Dmel_CG4167   Heat shock gene 67Ba
Drosophila melanogaster Dmel_CG4466   Heat shock protein 27
Drosophila melanogaster Dmel_CG4463   Heat shock protein 23
Drosophila melanogaster Dmel_CG4533   lethal (2) essential for life
Homo sapiens ENSG00000109846   crystallin, alpha B
Loa Loa (eye worm) LOAG_10614   hypothetical protein
Loa Loa (eye worm) LOAG_12701   small heat shock protein
Loa Loa (eye worm) LOAG_15850   small heat shock protein
Loa Loa (eye worm) LOAG_01002   small heat shock protein
Loa Loa (eye worm) LOAG_03753   small heat shock protein
Mus musculus ENSMUSG00000032060   crystallin, alpha B
Onchocerca volvulus OVOC8188  
Onchocerca volvulus OVOC12824   Protein lethal(2)essential for life homolog
Onchocerca volvulus OVOC12085   Protein lethal(2)essential for life homolog
Onchocerca volvulus OVOC2390   Protein lethal(2)essential for life homolog
Onchocerca volvulus OVOC51  
Onchocerca volvulus OVOC12899   Protein lethal(2)essential for life homolog
Onchocerca volvulus OVOC8358  
Onchocerca volvulus OVOC50  
Schmidtea mediterranea mk4.015603.00  

Essentiality

LOAG_03753 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_T27E4.8 Caenorhabditis elegans larval arrest wormbase
CELE_T27E4.8 Caenorhabditis elegans slow growth wormbase
CELE_Y46H3A.3 Caenorhabditis elegans larval arrest wormbase
CELE_Y46H3A.3 Caenorhabditis elegans slow growth wormbase
CELE_T27E4.2 Caenorhabditis elegans larval arrest wormbase
CELE_T27E4.2 Caenorhabditis elegans slow growth wormbase
CELE_F08H9.4 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Caenorhabditis elegans Protein HSP-16.2 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_03753 (Loa Loa (eye worm)), small heat shock protein
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