pI: 5.5345 |
Length (AA): 132 |
MW (Da): 14993 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 127 | 1zo2 (A) | 4 | 125 | 43.00 | 0 | 1 | 1.54992 | -1.13 |
4 | 130 | 3q90 (B) | 5 | 136 | 27.00 | 0 | 1 | 1.30202 | -1.17 |
4 | 132 | 1gy6 (A) | 4 | 126 | 43.00 | 0 | 1 | 1.52517 | -1.04 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127878)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G27970 | nuclear transport factor 2B |
Arabidopsis thaliana | AT1G27310 | nuclear transport factor 2A |
Arabidopsis thaliana | AT1G11570 | nuclear transport factor 2-like protein |
Babesia bovis | BBOV_III010930 | nuclear transport factor domain containing protein |
Brugia malayi | Bm1_17200 | nuclear transport factor 2 (NTF-2) |
Caenorhabditis elegans | CELE_R05D11.3 | Protein RAN-4 |
Cryptosporidium hominis | Chro.40075 | nuclear transport factor 2 (NTF-2) |
Cryptosporidium parvum | cgd4_590 | conserved hypothetical protein |
Dictyostelium discoideum | DDB_G0276425 | nuclear transport factor 2 |
Drosophila melanogaster | Dmel_CG10174 | Nuclear transport factor-2-related |
Drosophila melanogaster | Dmel_CG1740 | Nuclear transport factor-2 |
Echinococcus granulosus | EgrG_000601000 | nuclear transport factor 2 |
Entamoeba histolytica | EHI_182470 | nuclear transport factor 2, putative |
Echinococcus multilocularis | EmuJ_000601000 | nuclear transport factor 2 |
Giardia lamblia | GL50803_6724 | Protein F17L21.10 |
Homo sapiens | 10204 | nuclear transport factor 2 |
Leishmania braziliensis | LbrM.10.0950 | nuclear transport factor 2, putative,ntf2-like |
Leishmania donovani | LdBPK_100900.1 | nuclear transport factor 2, putative |
Leishmania infantum | LinJ.10.0900 | nuclear transport factor 2, putative,ntf2-like |
Leishmania major | LmjF.10.0850 | nuclear transport factor 2, putative,ntf2-like |
Leishmania mexicana | LmxM.10.0850 | nuclear transport factor 2, putative,ntf2-like |
Loa Loa (eye worm) | LOAG_07067 | hypothetical protein |
Loa Loa (eye worm) | LOAG_07068 | hypothetical protein |
Mus musculus | ENSMUSG00000008450 | nuclear transport factor 2 |
Mus musculus | 621832 | predicted gene 10349 |
Neospora caninum | NCLIV_033140 | hypothetical protein |
Oryza sativa | 4346137 | Os08g0532300 |
Oryza sativa | 4325860 | Os01g0788200 |
Onchocerca volvulus | OVOC1418 |
|
Plasmodium berghei | PBANKA_1030300 | nuclear transport factor 2, putative |
Plasmodium falciparum | PF3D7_1412300 | nuclear transport factor 2, putative |
Plasmodium knowlesi | PKNH_1346000 | nuclear transport factor 2, putative |
Plasmodium vivax | PVX_085840 | nuclear transport factor 2, putative |
Plasmodium yoelii | PY00424 | nuclear transport factor 2 |
Saccharomyces cerevisiae | YER009W | Ntf2p |
Schistosoma japonicum | Sjp_0217920 | Nuclear transport factor 2, putative |
Schistosoma mansoni | Smp_037700 | nuclear transport factor |
Schmidtea mediterranea | mk4.002155.04 | Probable nuclear transport factor 2 |
Schmidtea mediterranea | mk4.006583.00 | Probable nuclear transport factor 2 |
Schmidtea mediterranea | mk4.002305.00 | Probable nuclear transport factor 2 |
Trypanosoma brucei gambiense | Tbg972.8.4020 | nuclear transport factor 2, putative |
Trypanosoma brucei | Tb927.8.4280 | nuclear transport factor 2, putative |
Trypanosoma congolense | TcIL3000_8_4000 | nuclear transport factor 2, putative |
Trypanosoma cruzi | TcCLB.509567.40 | nuclear transport factor 2, putative |
Trypanosoma cruzi | TcCLB.511407.10 | nuclear transport factor 2, putative |
Toxoplasma gondii | TGME49_233350 | nuclear transport factor 2, putative |
Theileria parva | TP02_0050 | nuclear transport factor 2, putative |
Trichomonas vaginalis | TVAG_390880 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_296260 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_R05D11.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_R05D11.3 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_R05D11.3 | Caenorhabditis elegans | slow growth | wormbase |
CELE_R05D11.3 | Caenorhabditis elegans | sterile | wormbase |
YER009W | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_233350 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.