Detailed view for LOAG_06982

Basic information

TDR Targets ID: 937680
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 8.5715 | Length (AA): 737 | MW (Da): 83899 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00076   RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0003676   nucleic acid binding  
GO:0006396   RNA processing  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 407 4eba (A) 152 637 13.00 0 1 0.565339 0.53
2 406 5ctq (A) 211 609 32.00 0 1 0.926725 -0.16
4 359 2ooe (A) 129 503 22.00 0.0035 1 0.578239 0.56
84 379 5ctr (A) 283 584 24.00 0 1 0.690728 -0.23
559 654 2do4 (A) 787 882 43.00 0 1 0.660358 -0.54
571 647 6gd1 (A) 112 189 30.00 0.1 1 0.638978 -1.58
577 630 2cq0 (A) 243 297 37.00 0.014 1 0.56147 -0.37

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129455)

Species Accession Gene Product
Arabidopsis thaliana AT4G24270   protein embryo defective 140
Brugia malayi Bm1_01040   hypothetical protein
Candida albicans CaO19.2563   U4/U6 snRNP spliceosome factor
Candida albicans CaO19.10095   U4/U6 snRNP spliceosome factor
Caenorhabditis elegans CELE_B0035.12   Protein B0035.12
Dictyostelium discoideum DDB_G0291836   hypothetical protein
Drosophila melanogaster Dmel_CG3312   RNA-binding protein 4F
Echinococcus granulosus EgrG_000931100   squamous cell carcinoma antigen
Echinococcus multilocularis EmuJ_000931100   squamous cell carcinoma antigen
Homo sapiens ENSG00000075856   squamous cell carcinoma antigen recognized by T cells 3
Loa Loa (eye worm) LOAG_09122   hypothetical protein
Loa Loa (eye worm) LOAG_06982   hypothetical protein
Mus musculus ENSMUSG00000018974   squamous cell carcinoma antigen recognized by T cells 3
Oryza sativa 4344498   Os08g0113200
Saccharomyces cerevisiae YMR268C   Prp24p
Schistosoma japonicum Sjp_0052270   Squamous cell carcinoma antigen recognized by T-cells 3, putative
Schistosoma japonicum Sjp_0110520   IPR002197,Helix-turn-helix, Fis-type,domain-containing
Schistosoma japonicum Sjp_0123340   expressed protein
Schistosoma mansoni Smp_078240   hypothetical protein
Schmidtea mediterranea mk4.000371.09   RNA-binding protein 4F
Schmidtea mediterranea mk4.001682.02  
Schmidtea mediterranea mk4.007841.00  
Schmidtea mediterranea mk4.006159.00  
Schmidtea mediterranea mk4.000872.00   RNA-binding protein 4F
Schmidtea mediterranea mk4.004713.04  
Schmidtea mediterranea mk4.000598.08  
Schmidtea mediterranea mk4.020990.00  
Schmidtea mediterranea mk4.016992.00   RNA-binding protein 4F
Schmidtea mediterranea mk4.001084.03  
Schmidtea mediterranea mk4.020243.01  
Schmidtea mediterranea mk4.009287.00  
Schmidtea mediterranea mk4.000579.04  
Schmidtea mediterranea mk4.000202.06  
Schmidtea mediterranea mk4.011595.00  
Schmidtea mediterranea mk4.007664.02  
Schmidtea mediterranea mk4.027659.01  
Schmidtea mediterranea mk4.005472.00  
Schmidtea mediterranea mk4.030392.00  
Schmidtea mediterranea mk4.011367.05  
Schmidtea mediterranea mk4.013401.00   RNA-binding protein 4F
Schmidtea mediterranea mk4.016350.00  
Schmidtea mediterranea mk4.006525.01  
Schmidtea mediterranea mk4.024042.00  
Schmidtea mediterranea mk4.011492.00  
Schmidtea mediterranea mk4.005557.01  
Schmidtea mediterranea mk4.012755.00  
Schmidtea mediterranea mk4.012895.01  
Schmidtea mediterranea mk4.008672.01  
Schmidtea mediterranea mk4.001813.00  
Schmidtea mediterranea mk4.000957.09  
Schmidtea mediterranea mk4.023794.01  
Schmidtea mediterranea mk4.016184.01  
Schmidtea mediterranea mk4.011343.00  
Schmidtea mediterranea mk4.002312.01  
Schmidtea mediterranea mk4.010227.01  
Schmidtea mediterranea mk4.001171.12  
Schmidtea mediterranea mk4.001823.00  
Schmidtea mediterranea mk4.006502.04  
Schmidtea mediterranea mk4.000886.01  
Schmidtea mediterranea mk4.024678.00  
Schmidtea mediterranea mk4.016326.01  
Schmidtea mediterranea mk4.009009.00  
Schmidtea mediterranea mk4.002799.00  
Schmidtea mediterranea mk4.000259.01  
Schmidtea mediterranea mk4.005948.00  
Schmidtea mediterranea mk4.009334.00  
Schmidtea mediterranea mk4.029340.00  
Schmidtea mediterranea mk4.002210.02   RNA-binding protein 4F
Schmidtea mediterranea mk4.008110.04   RNA-binding protein 4F
Schmidtea mediterranea mk4.023004.01  
Schmidtea mediterranea mk4.000968.02  
Schmidtea mediterranea mk4.029216.00   RNA-binding protein 4F
Schmidtea mediterranea mk4.009340.00  
Schmidtea mediterranea mk4.000977.10   RNA-binding protein 4F
Schmidtea mediterranea mk4.001803.01  
Schmidtea mediterranea mk4.003762.03  
Schmidtea mediterranea mk4.003060.05   RNA-binding protein 4F
Schmidtea mediterranea mk4.014371.00   RNA-binding protein 4F
Schmidtea mediterranea mk4.008823.00  
Schmidtea mediterranea mk4.018326.00   RNA-binding protein 4F
Schmidtea mediterranea mk4.014696.00   RNA-binding protein 4F
Schmidtea mediterranea mk4.021101.01  
Schmidtea mediterranea mk4.002068.02  
Schmidtea mediterranea mk4.001911.06   RNA-binding protein 4F
Schmidtea mediterranea mk4.032775.00  
Schmidtea mediterranea mk4.014630.00  
Schmidtea mediterranea mk4.011220.01  
Schmidtea mediterranea mk4.016884.01  
Schmidtea mediterranea mk4.000896.01  
Schmidtea mediterranea mk4.024271.01  
Schmidtea mediterranea mk4.026755.00  
Schmidtea mediterranea mk4.012062.01  
Schmidtea mediterranea mk4.000502.06   RNA-binding protein 4F
Schmidtea mediterranea mk4.019085.01   RNA-binding protein 4F
Schmidtea mediterranea mk4.016049.01   RNA-binding protein 4F
Schmidtea mediterranea mk4.013987.00   RNA-binding protein 4F
Schmidtea mediterranea mk4.002454.00  
Schmidtea mediterranea mk4.020950.02  
Schmidtea mediterranea mk4.000084.09  
Schmidtea mediterranea mk4.000193.10  
Schmidtea mediterranea mk4.031335.02  
Schmidtea mediterranea mk4.003336.01  
Schmidtea mediterranea mk4.001663.06   RNA-binding protein 4F
Schmidtea mediterranea mk4.004870.02   RNA-binding protein 4F
Schmidtea mediterranea mk4.030694.00  
Schmidtea mediterranea mk4.027905.02   RNA-binding protein 4F
Schmidtea mediterranea mk4.001647.03  
Schmidtea mediterranea mk4.028846.00  
Schmidtea mediterranea mk4.004674.04  
Schmidtea mediterranea mk4.002836.09  
Schmidtea mediterranea mk4.001616.01  
Schmidtea mediterranea mk4.024175.02  
Schmidtea mediterranea mk4.009975.00  
Schmidtea mediterranea mk4.003448.01  
Schmidtea mediterranea mk4.000113.01  
Schmidtea mediterranea mk4.027294.01  
Schmidtea mediterranea mk4.008671.00  
Schmidtea mediterranea mk4.008323.05  
Schmidtea mediterranea mk4.008936.03  
Schmidtea mediterranea mk4.000044.18   RNA-binding protein 4F
Schmidtea mediterranea mk4.001164.06  
Schmidtea mediterranea mk4.002811.08  
Schmidtea mediterranea mk4.013148.01   RNA-binding protein 4F
Schmidtea mediterranea mk4.000839.01  
Schmidtea mediterranea mk4.012192.00   RNA-binding protein 4F
Schmidtea mediterranea mk4.019835.00  
Schmidtea mediterranea mk4.017718.01  
Schmidtea mediterranea mk4.005965.00  
Schmidtea mediterranea mk4.024125.00  
Schmidtea mediterranea mk4.003523.00  
Schmidtea mediterranea mk4.009780.00  
Schmidtea mediterranea mk4.012881.00  
Schmidtea mediterranea mk4.017807.00  
Schmidtea mediterranea mk4.005124.02  
Schmidtea mediterranea mk4.002941.03  
Schmidtea mediterranea mk4.015606.00  
Schmidtea mediterranea mk4.005360.00   RNA-binding protein 4F
Schmidtea mediterranea mk4.001353.04  
Schmidtea mediterranea mk4.000765.02  
Schmidtea mediterranea mk4.000627.04  
Schmidtea mediterranea mk4.027169.00  
Schmidtea mediterranea mk4.004453.01   RNA-binding protein 4F
Schmidtea mediterranea mk4.005221.02  
Schmidtea mediterranea mk4.002551.02   RNA-binding protein 4F
Schmidtea mediterranea mk4.001154.07   RNA-binding protein 4F
Schmidtea mediterranea mk4.022267.00  
Schmidtea mediterranea mk4.001135.01  
Schmidtea mediterranea mk4.000782.00  
Schmidtea mediterranea mk4.005428.02  
Schmidtea mediterranea mk4.000265.19  
Schmidtea mediterranea mk4.007073.01  
Schmidtea mediterranea mk4.016919.01  
Schmidtea mediterranea mk4.021611.04  
Schmidtea mediterranea mk4.004036.02   RNA-binding protein 4F
Schmidtea mediterranea mk4.017310.01  
Schmidtea mediterranea mk4.001656.04  
Schmidtea mediterranea mk4.010336.00   RNA-binding protein 4F
Schmidtea mediterranea mk4.006590.02   RNA-binding protein 4F
Schmidtea mediterranea mk4.000198.10   RNA-binding protein 4F
Schmidtea mediterranea mk4.004742.01  
Schmidtea mediterranea mk4.000390.13   RNA-binding protein 4F
Schmidtea mediterranea mk4.007713.00  
Schmidtea mediterranea mk4.002320.00   RNA-binding protein 4F
Schmidtea mediterranea mk4.009643.00  
Schmidtea mediterranea mk4.001758.00  
Schmidtea mediterranea mk4.007296.03  
Schmidtea mediterranea mk4.021723.01   RNA-binding protein 4F
Schmidtea mediterranea mk4.003842.00  
Schmidtea mediterranea mk4.013655.00  
Schmidtea mediterranea mk4.011278.01  
Schmidtea mediterranea mk4.021060.00  
Schmidtea mediterranea mk4.021894.00  
Schmidtea mediterranea mk4.004871.00  
Schmidtea mediterranea mk4.002503.01   RNA-binding protein 4F
Schmidtea mediterranea mk4.001816.02  
Schmidtea mediterranea mk4.000011.20   RNA-binding protein 4F
Schmidtea mediterranea mk4.022185.01  
Schmidtea mediterranea mk4.001137.03  
Schmidtea mediterranea mk4.021593.00  
Schmidtea mediterranea mk4.010113.00  
Schmidtea mediterranea mk4.020366.00  
Schmidtea mediterranea mk4.012052.01   RNA-binding protein 4F
Schmidtea mediterranea mk4.021964.00  
Schmidtea mediterranea mk4.029944.01  
Schmidtea mediterranea mk4.022816.01  
Schmidtea mediterranea mk4.001116.01  
Schmidtea mediterranea mk4.031662.00  
Schmidtea mediterranea mk4.036296.00   RNA-binding protein 4F
Schmidtea mediterranea mk4.006263.00  
Schmidtea mediterranea mk4.000662.00  
Schmidtea mediterranea mk4.006957.01  
Schmidtea mediterranea mk4.026201.00   RNA-binding protein 4F
Schmidtea mediterranea mk4.002436.05  
Schmidtea mediterranea mk4.020587.01  
Schmidtea mediterranea mk4.000073.03   RNA-binding protein 4F
Schmidtea mediterranea mk4.006415.01  
Schmidtea mediterranea mk4.013346.00  
Schmidtea mediterranea mk4.006924.00  
Schmidtea mediterranea mk4.008161.00  
Schmidtea mediterranea mk4.020267.01  
Schmidtea mediterranea mk4.007785.04  
Schmidtea mediterranea mk4.001359.03  
Schmidtea mediterranea mk4.020568.00  
Schmidtea mediterranea mk4.000419.04  
Schmidtea mediterranea mk4.015957.01   RNA-binding protein 4F
Schmidtea mediterranea mk4.026322.00  
Schmidtea mediterranea mk4.003647.00  
Schmidtea mediterranea mk4.001624.00   RNA-binding protein 4F
Schmidtea mediterranea mk4.000481.11  
Schmidtea mediterranea mk4.006255.01  
Schmidtea mediterranea mk4.017393.00  
Trichomonas vaginalis TVAG_352170   RNA-binding protein, putative

Essentiality

LOAG_06982 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_B0035.12 Caenorhabditis elegans embryonic lethal wormbase
CELE_B0035.12 Caenorhabditis elegans larval arrest wormbase
CELE_B0035.12 Caenorhabditis elegans slow growth wormbase
YMR268C Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_06982 (Loa Loa (eye worm)), hypothetical protein
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