pI: 7.8311 |
Length (AA): 192 |
MW (Da): 21708 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_128527)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G03667 | asparagine synthase |
Babesia bovis | BBOV_IV006020 | asparagine synthase, putative |
Brugia malayi | Bm1_38315 | Asparagine synthase family protein |
Candida albicans | CaO19.11109 | similar to S. cerevisiae YML096W |
Candida albicans | CaO19.3626 | similar to S. cerevisiae YML096W |
Caenorhabditis elegans | CELE_M18.3 | Protein M18.3 |
Dictyostelium discoideum | DDB_G0278193 | hypothetical protein |
Drosophila melanogaster | Dmel_CG17486 | CG17486 gene product from transcript CG17486-RB |
Echinococcus granulosus | EgrG_000668900 | asparagine synthetase domain containing protein |
Entamoeba histolytica | EHI_125770 | hypothetical protein, conserved |
Echinococcus multilocularis | EmuJ_000668900 | asparagine synthetase domain containing protein |
Giardia lamblia | GL50803_3372 | Asparagine synthase, putative |
Homo sapiens | ENSG00000138381 | asparagine synthetase domain containing 1 |
Leishmania braziliensis | LbrM.29.1580 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_291590.1 | asparagine synthase, putative |
Leishmania infantum | LinJ.29.1590 | hypothetical protein, conserved |
Leishmania major | LmjF.29.1490 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.08_29.1490 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_10277 | hypothetical protein |
Loa Loa (eye worm) | LOAG_12443 | asparagine synthase |
Mus musculus | ENSMUSG00000026095 | asparagine synthetase domain containing 1 |
Oryza sativa | 4352605 | Os12g0574900 |
Onchocerca volvulus | OVOC4268 | Alternative protein ASNSD1 homolog |
Saccharomyces cerevisiae | YML096W | putative asparagine synthase |
Schistosoma japonicum | Sjp_0311240 | ko:K01953 asparagine synthase (glutamine-hydrolysing) [EC6.3.5.4], putative |
Schistosoma mansoni | Smp_133560 | asparagine synthetase |
Schmidtea mediterranea | mk4.002665.01 | Alternative protein ASNSD1 |
Trypanosoma brucei gambiense | Tbg972.3.4470 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.3.4060 | asparagine synthetase domain-containing protein 1 |
Trypanosoma congolense | TcIL3000_3_2700 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.510001.40 | asparagine synthase, putative |
Trypanosoma cruzi | TcCLB.507529.40 | asparagine synthase, putative |
Theileria parva | TP01_0405 | hypothetical protein |
Trichomonas vaginalis | TVAG_473930 | asparagine synthetase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.3.4060 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.3.4060 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.3.4060 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.3.4060 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.