Detailed view for LOAG_06367

Basic information

TDR Targets ID: 938042
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 7.7082 | Length (AA): 856 | MW (Da): 94621 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

mRNA surveillance pathway (KEGG)

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 136 1sz9 (A) 3 138 27.00 0 1 0.596042 -2.01
4 136 5ce7 (A) 2 140 15.00 0 0.98 0.467874 -1.47
132 211 4kph (H) 120 211 31.00 0.46 0.37 0.357458 -0.2
140 211 3u9p (K) 130 214 31.00 0.12 0.46 0.428112 -0.31
752 820 2nax (A) 534 604 26.00 0 0.62 0.352107 -0.3

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129507)

Species Accession Gene Product
Arabidopsis thaliana AT4G04885   PCF11P-similar protein 4
Brugia malayi Bm1_44480   hypothetical protein
Candida albicans CaO19.8302   similar to S. cerevisiae PCF11 (YDR228C) subunit of pre-mRNA cleavage factor CFI involved in polyadenylation
Candida albicans CaO19.684   similar to S. cerevisiae PCF11 (YDR228C) subunit of pre-mRNA cleavage factor CFI involved in polyadenylation
Caenorhabditis elegans CELE_R144.2   Protein PCF-11, isoform B
Dictyostelium discoideum DDB_G0279559   ENTH domain-containing protein
Drosophila melanogaster Dmel_CG10228   Inverse regulator a
Echinococcus granulosus EgrG_001068800   ENTH VHS domain containing protein
Echinococcus multilocularis EmuJ_001068800   ENTH (VHS) domain containing protein
Homo sapiens 51585   PCF11 cleavage and polyadenylation factor subunit
Loa Loa (eye worm) LOAG_06367   hypothetical protein
Mus musculus ENSMUSG00000041328   cleavage and polyadenylation factor subunit homolog (S. cerevisiae)
Oryza sativa 4344833   Os08g0187700
Saccharomyces cerevisiae YDR228C   Pcf11p
Schistosoma japonicum Sjp_0027180   Pre-mRNA cleavage complex 2 protein Pcf11, putative
Schistosoma mansoni Smp_168190   hypothetical protein
Schistosoma mansoni Smp_084870   hypothetical protein
Schmidtea mediterranea mk4.001275.05  
Schmidtea mediterranea mk4.006105.01   Polyadenylation and cleavage factor homolog 11
Schmidtea mediterranea mk4.006659.00   Polyadenylation and cleavage factor homolog 11

Essentiality

LOAG_06367 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_R144.2 Caenorhabditis elegans adult lethal wormbase
CELE_R144.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_R144.2 Caenorhabditis elegans larval lethal wormbase
CELE_R144.2 Caenorhabditis elegans sterile wormbase
YDR228C Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_06367 (Loa Loa (eye worm)), hypothetical protein
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