Detailed view for LOAG_09207

Basic information

TDR Targets ID: 939251
Loa Loa (eye worm), surfeit 4
Source Database / ID:  KEGG  

pI: 9.3057 | Length (AA): 102 | MW (Da): 11875 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 3

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02077   SURF4 family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130182)

Species Accession Gene Product
Brugia malayi Bm1_20645   Surfeit locus protein 4 homolog
Candida albicans CaO19.12048   SURF4 family
Candida albicans CaO19.4579   SURF4 family
Caenorhabditis elegans CELE_C54H2.5   Protein SFT-4
Drosophila melanogaster Dmel_CG6202   Surfeit 4
Echinococcus granulosus EgrG_000896600   surfeit locus protein 4
Echinococcus multilocularis EmuJ_000896600   surfeit locus protein 4
Homo sapiens ENSG00000148248   surfeit 4
Loa Loa (eye worm) LOAG_09207   surfeit 4
Mus musculus ENSMUSG00000014867   surfeit gene 4
Onchocerca volvulus OVOC3254   Surfeit locus protein 4 homolog
Saccharomyces cerevisiae YGR284C   Erv29p
Schistosoma japonicum Sjp_0200450   Surfeit locus protein 4, putative
Schistosoma mansoni Smp_174450   surfeit locus protein
Schmidtea mediterranea mk4.009970.02   Surfeit locus protein 4
Schmidtea mediterranea mk4.013129.01   Surfeit locus protein 4 homolog
Schmidtea mediterranea mk4.000925.13   Surfeit locus protein 4
Schmidtea mediterranea mk4.000925.12   Surfeit 4-1
Schmidtea mediterranea mk4.027266.00   Surfeit locus protein 4 homolog
Schmidtea mediterranea mk4.000836.04   Surfeit locus protein 4

Essentiality

LOAG_09207 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C54H2.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_C54H2.5 Caenorhabditis elegans larval arrest wormbase
CELE_C54H2.5 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier LOAG_09207 (Loa Loa (eye worm)), surfeit 4
Title for this comment
Comment