Detailed view for LOAG_07209

Basic information

TDR Targets ID: 939263
Loa Loa (eye worm), sulfotransferase domain-containing protein
Source Database / ID:  KEGG  

pI: 7.8917 | Length (AA): 409 | MW (Da): 47206 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00685   Sulfotransferase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0008146   sulfotransferase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
31 316 2q3m (A) 26 320 22.00 0 1 0.715366 0.19
43 317 1g3m (A) 5 287 27.00 0 1 1.04847 -1.13
47 323 1q1q (A) 13 296 32.00 0 1 1.06836 -0.79
75 321 1q1q (A) 44 294 36.00 0 1 1.00131 -0.49

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126675)

Species Accession Gene Product
Arabidopsis thaliana AT2G03770   cytosolic sulfotransferase 13
Arabidopsis thaliana AT1G18590   sulfotransferase 17
Arabidopsis thaliana AT1G28170   sulfotransferase 7
Arabidopsis thaliana AT4G26280   sulfotransferase 3
Arabidopsis thaliana AT1G13430   sulfotransferase 4C
Arabidopsis thaliana AT2G03760   sulphotransferase 12
Arabidopsis thaliana AT1G74090   desulfo-glucosinolate sulfotransferase 18
Arabidopsis thaliana AT1G13420   sulfotransferase 4B
Arabidopsis thaliana AT2G03750   cytosolic sulfotransferase 11
Arabidopsis thaliana AT5G07000   sulfotransferase 2B
Arabidopsis thaliana AT3G45070   sulfotransferase 5
Arabidopsis thaliana AT5G07010   sulfotransferase 2A
Arabidopsis thaliana AT3G45080   cytosolic sulfotransferase 6
Arabidopsis thaliana AT5G43690   sulfotransferase 1
Arabidopsis thaliana AT2G27570   P-loop containing nucleoside triphosphate hydrolases superfamily protein
Arabidopsis thaliana AT2G14920   sulfotransferase 4A
Arabidopsis thaliana AT1G74100   desulfo-glucosinolate sulfotransferase 16
Brugia malayi Bm1_51335   Sulfotransferase domain containing protein
Caenorhabditis elegans CELE_Y113G7A.11   Protein SSU-1
Dictyostelium discoideum DDB_G0274373   hypothetical protein
Drosophila melanogaster Dmel_CG16733   Sulfotransferase 2
Drosophila melanogaster Dmel_CG44167   Sulfotransferase 3
Homo sapiens ENSG00000198203   sulfotransferase family, cytosolic, 1C, member 2
Homo sapiens ENSG00000198075   sulfotransferase family, cytosolic, 1C, member 4
Homo sapiens 27284   sulfotransferase family, cytosolic, 1B, member 1
Loa Loa (eye worm) LOAG_07209   sulfotransferase domain-containing protein
Mus musculus ENSMUSG00000029269   sulfotransferase family 1B, member 1
Mus musculus ENSMUSG00000029273   sulfotransferase family 1D, member 1
Mus musculus 69083   sulfotransferase family, cytosolic, 1C, member 2
Oryza sativa 4342402   Os07g0148600
Oryza sativa 9269362   Os12g0137900
Oryza sativa 9267617   Os12g0137700
Oryza sativa 9270598   Os04g0359300
Oryza sativa 4345031   Os08g0239900
Oryza sativa 4351454   Os12g0137600
Oryza sativa 9268444   Os11g0450300
Oryza sativa 4348233   Os10g0190100
Oryza sativa 4351955   Os12g0270900
Oryza sativa 4345205   Os08g0297800
Oryza sativa 9271579   Os11g0505200
Oryza sativa 4346028   Os08g0515000
Oryza sativa 4346029   Os08g0515100
Oryza sativa 4350564   Os11g0503900
Oryza sativa 4336454   Os04g0526300
Oryza sativa 4327280   Os01g0311600
Oryza sativa 9266577   Os06g0252800
Oryza sativa 4346532   Os09g0256100
Oryza sativa 9271189   Os09g0555150
Oryza sativa 4341575   Os06g0626600
Oryza sativa 4343853   Os07g0605800
Oryza sativa 4345032   Os08g0240000
Onchocerca volvulus OVOC6928  
Onchocerca volvulus OVOC12553  
Schmidtea mediterranea mk4.016599.01   Sulfotransferase 6B1
Schmidtea mediterranea mk4.001184.03   Sulfotransferase 6B1
Schmidtea mediterranea mk4.000122.02   Sulfotransferase 6B1
Schmidtea mediterranea mk4.017922.01   Sulfotransferase 6B1
Toxoplasma gondii TGME49_228140   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bos taurus Estrogen sulfotransferase 295 aa 29.8% 258 aa Compounds References
Sus scrofa Estrogen sulfotransferase 295 aa 29.7% 269 aa Compounds References
Obtained from network model

Ranking Plot

No enough druggable targets predicted through repurposing network model to make a plot

Putative Drugs List

Compound Raw Global Species
0.0011 0.4151 0.4097

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_07209 (Loa Loa (eye worm)), sulfotransferase domain-containing protein
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