pI: 5.5723 |
Length (AA): 1406 |
MW (Da): 155393 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 10 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
10 | 451 | 2fo0 (A) | 84 | 528 | 23.00 | 0 | 1 | 0.439667 | 0.51 |
10 | 440 | 2c0t (A) | 61 | 498 | 26.00 | 0 | 1 | 0.432843 | 0.4 |
49 | 436 | 5xzw (B) | 66 | 466 | 28.00 | 0 | 1 | 0.42426 | 0.68 |
101 | 492 | 5uvc (A) | 88 | 528 | 21.00 | 0 | 1 | 0.318105 | 0.35 |
111 | 424 | 4wb7 (A) | 41 | 335 | 28.00 | 0.000000000069 | 1 | 0.487029 | -0.27 |
158 | 519 | 5o2c (A) | 131 | 496 | 63.00 | 0 | 1 | 0.992768 | -0.69 |
174 | 726 | 4kik (A) | 15 | 637 | 22.00 | 0 | 1 | 0.463614 | 0.66 |
438 | 521 | 2lru (A) | 479 | 572 | 39.00 | 0.00000014 | 1 | 0.529444 | -1.23 |
626 | 691 | 5g3q (A) | 1120 | 1186 | 32.00 | 0.58 | 1 | 0.604642 | -1.81 |
703 | 820 | 2mqa (A) | 35 | 138 | 35.00 | 0.76 | 0.14 | 0.298226 | -0.04 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127736)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G64630 | putative serine/threonine-protein kinase WNK10 |
Arabidopsis thaliana | AT1G49160 | putative serine/threonine-protein kinase WNK7 |
Arabidopsis thaliana | AT5G41990 | serine/threonine-protein kinase WNK8 |
Arabidopsis thaliana | AT3G48260 | putative serine/threonine-protein kinase WNK3 |
Brugia malayi | Bm1_22880 | Protein kinase domain containing protein |
Caenorhabditis elegans | CELE_C46C2.1 | Protein WNK-1, isoform L |
Drosophila melanogaster | Dmel_CG7177 | WNK homolog |
Echinococcus granulosus | EgrG_000259100 | serine:threonine protein kinase WNK1 |
Echinococcus granulosus | EgrG_002005000 | 5'partial|protein kinase |
Echinococcus multilocularis | EmuJ_000017500 | protein kinase |
Echinococcus multilocularis | EmuJ_000259100 | serine:threonine protein kinase WNK1 |
Giardia lamblia | GL50803_90343 | Kinase, Wnk |
Homo sapiens | ENSG00000126562 | WNK lysine deficient protein kinase 4 |
Homo sapiens | ENSG00000196632 | WNK lysine deficient protein kinase 3 |
Homo sapiens | ENSG00000060237 | WNK lysine deficient protein kinase 1 |
Homo sapiens | ENSG00000165238 | WNK lysine deficient protein kinase 2 |
Loa Loa (eye worm) | LOAG_12245 | hypothetical protein |
Loa Loa (eye worm) | LOAG_06201 | WNK protein kinase |
Mus musculus | ENSMUSG00000037989 | WNK lysine deficient protein kinase 2 |
Mus musculus | ENSMUSG00000035112 | WNK lysine deficient protein kinase 4 |
Mus musculus | ENSMUSG00000041245 | WNK lysine deficient protein kinase 3 |
Mus musculus | ENSMUSG00000045962 | WNK lysine deficient protein kinase 1 |
Oryza sativa | 4342585 | Os07g0185000 |
Oryza sativa | 4330286 | Os02g0672800 |
Oryza sativa | 4337579 | Os05g0108300 |
Schistosoma japonicum | Sjp_0040710 | ko:K08867 WNK lysine deficient protein kinase, putative |
Schistosoma japonicum | Sjp_0040670 | Methionine-R-sulfoxide reductase B3, mitochondrial precursor, putative |
Schistosoma mansoni | Smp_154440 | protein kinase |
Schmidtea mediterranea | mk4.000805.03 | Protein kinase |
Schmidtea mediterranea | mk4.002865.03 | |
Schmidtea mediterranea | mk4.002865.00 | |
Schmidtea mediterranea | mk4.026761.00 | WNK homolog |
Schmidtea mediterranea | mk4.000281.01 | |
Schmidtea mediterranea | mk4.002865.04 | WNK homolog |
Trichomonas vaginalis | TVAG_388240 | STE family protein kinase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_C46C2.1 | Caenorhabditis elegans | slow growth | wormbase |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | WNK lysine deficient protein kinase 3 | Compounds | References |
Homo sapiens | WNK lysine deficient protein kinase 1 | Compounds | References |
Homo sapiens | WNK lysine deficient protein kinase 2 | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Rattus norvegicus | Jak1 protein | 210 aa | 29.3% | 205 aa | Compounds | References |
Sus scrofa | Casein kinase I isoform alpha | 125 aa | 28.0% | 107 aa | Compounds | References |
Rattus norvegicus | Serine/threonine-protein kinase pim-3 | 326 aa | 23.3% | 270 aa | Compounds | References |
Oryctolagus cuniculus | Cyclin-dependent kinase 4 | 189 aa | 33.8% | 160 aa | Compounds | References |