Detailed view for LOAG_13957

Basic information

TDR Targets ID: 940175
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 6.6428 | Length (AA): 379 | MW (Da): 42158 | Paralog Number: 4

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01833   IPT/TIG domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0071526   GO:semaphorin-plexin signaling pathway  

GO:0017154   semaphorin receptor activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 379 5l5g (C) 604 1008 27.00 0 1 1.1538 1.34
49 83 3al9 (A) 510 544 46.00 0.13 1 0.508348 0.74
235 325 1uad (C) 8 95 22.00 0 0.77 0.502106 -0.61
235 311 1uad (C) 8 83 29.00 0.26 0.77 0.589166 -0.79

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127010)

Species Accession Gene Product
Brugia malayi Bm1_38550   plexin A
Caenorhabditis elegans CELE_K04B12.1   Protein PLX-2
Caenorhabditis elegans CELE_Y55F3AL.1   Protein PLX-1
Drosophila melanogaster Dmel_CG17245   Plexin B
Drosophila melanogaster Dmel_CG11081   Plexin A
Echinococcus granulosus EgrG_000810300   plexin a4
Echinococcus multilocularis EmuJ_000810300   plexin a4
Homo sapiens ENSG00000196576   plexin B2
Homo sapiens ENSG00000221866   plexin A4
Homo sapiens ENSG00000004399   plexin D1
Homo sapiens ENSG00000130827   plexin A3
Homo sapiens ENSG00000164050   plexin B1
Homo sapiens ENSG00000114554   plexin A1
Homo sapiens ENSG00000198753   plexin B3
Homo sapiens ENSG00000076356   plexin A2
Loa Loa (eye worm) LOAG_08397   hypothetical protein
Loa Loa (eye worm) LOAG_13957   hypothetical protein
Loa Loa (eye worm) LOAG_11202   hypothetical protein
Loa Loa (eye worm) LOAG_01783   plexin A
Loa Loa (eye worm) LOAG_09653   hypothetical protein
Mus musculus ENSMUSG00000053646   plexin B1
Mus musculus ENSMUSG00000031385   plexin B3
Mus musculus ENSMUSG00000030084   plexin A1
Mus musculus ENSMUSG00000029765   plexin A4
Mus musculus ENSMUSG00000030123   plexin D1
Mus musculus ENSMUSG00000036606   plexin B2
Mus musculus ENSMUSG00000026640   plexin A2
Mus musculus ENSMUSG00000031398   plexin A3
Schistosoma japonicum Sjp_0040950   ko:K06820 plexin A, putative
Schistosoma japonicum Sjp_0311740   expressed protein
Schistosoma japonicum Sjp_0040960   ko:K06820 plexin A, putative
Schistosoma mansoni Smp_145420   plexin
Schmidtea mediterranea mk4.001017.06  
Schmidtea mediterranea mk4.001017.04  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_13957 (Loa Loa (eye worm)), hypothetical protein
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