Detailed view for LOAG_00806

Basic information

TDR Targets ID: 940235
Loa Loa (eye worm), Klhl5 protein
Source Database / ID:  KEGG  

pI: 6.4931 | Length (AA): 752 | MW (Da): 82554 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00651   BTB/POZ domain
PF01344   Kelch motif
PF07707   BTB And C-terminal Kelch

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
12 270 3hu6 (B) 46 328 16.00 0 1 0.430615 0.92
437 718 2vpj (A) 279 563 38.00 0 1 0.8862 -0.65
437 718 6hrl (A) 338 618 43.00 0 1 0.9665 -0.77
439 718 1zgk (A) 326 607 41.00 0 1 0.93254 -0.95
647 749 2dyh (A) 489 592 32.00 0.02 0.64 0.486768 0.11

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_136030)

Species Accession Gene Product
Brugia malayi Bm1_52105   Kelch motif family protein
Caenorhabditis elegans CELE_W02G9.2   Protein KEL-8
Dictyostelium discoideum DDB_G0271500   Kelch repeat-containing protein
Homo sapiens ENSG00000145332   kelch-like family member 8
Loa Loa (eye worm) LOAG_00806   Klhl5 protein
Mus musculus ENSMUSG00000029312   kelch-like 8

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_00806 (Loa Loa (eye worm)), Klhl5 protein
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