Detailed view for LOAG_01703

Basic information

TDR Targets ID: 940251
Loa Loa (eye worm), rho-GTPase-activating
Source Database / ID:  KEGG  

pI: 7.6035 | Length (AA): 394 | MW (Da): 46239 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00169   PH domain
PF16746   BAR domain of APPL family

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 371 2q13 (A) 4 376 13.00 0.000000000014 0.38 1.05495 0.27
6 365 4nsw (A) 5 355 25.00 0.00000000029 1 0.895406 1.08
23 206 1uru (A) 33 242 10.00 0 0.03 0.394805 -0.57
96 275 1t94 (A) 334 499 31.00 0.46 0.52 0.483553 0.85
282 378 1x05 (A) 27 128 15.00 0.82 0.03 0.245593 0.71

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129464)

Species Accession Gene Product
Brugia malayi Bm1_00530   Rho-GTPase-activating
Brugia malayi Bm1_00535   RhoGAP domain containing protein
Caenorhabditis elegans CELE_T04C9.1   Protein T04C9.1, isoform A
Drosophila melanogaster Dmel_CG8948   GRAF ortholog (H. sapiens)
Homo sapiens ENSG00000165895   Rho GTPase activating protein 42
Homo sapiens ENSG00000079482   oligophrenin 1
Homo sapiens ENSG00000145819   Rho GTPase activating protein 26
Homo sapiens ENSG00000071205   Rho GTPase activating protein 10
Loa Loa (eye worm) LOAG_01702   hypothetical protein
Loa Loa (eye worm) LOAG_01703   rho-GTPase-activating
Mus musculus 94190   oligophrenin 1
Mus musculus ENSMUSG00000037148   Rho GTPase activating protein 10
Mus musculus ENSMUSG00000036452   Rho GTPase activating protein 26
Mus musculus ENSMUSG00000050730   Rho GTPase activating protein 42
Onchocerca volvulus OVOC8126   Putative oligophrenin
Schistosoma japonicum Sjp_0031980   Rho GTPase-activating protein 10, putative
Schistosoma japonicum Sjp_0123350   IPR000198,RhoGAP;IPR008936,Rho GTPase activation protein,domain-containing
Schistosoma japonicum Sjp_0105910   IPR000198,RhoGAP;IPR008936,Rho GTPase activation protein,domain-containing
Schistosoma mansoni Smp_122680   oligophrenin
Schmidtea mediterranea mk4.005621.02  
Schmidtea mediterranea mk4.005621.03   Putative oligophrenin
Schmidtea mediterranea mk4.019450.00   Putative oligophrenin

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier LOAG_01703 (Loa Loa (eye worm)), rho-GTPase-activating
Title for this comment
Comment