Detailed view for LOAG_08516

Basic information

TDR Targets ID: 940512
Loa Loa (eye worm), cAMP-dependent protein kinase regulatory subunit
Source Database / ID:  KEGG  

pI: 4.8779 | Length (AA): 357 | MW (Da): 39633 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00027   Cyclic nucleotide-binding domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005952   cAMP-dependent protein kinase complex  
GO:0008603   cAMP-dependent protein kinase regulator activity  
GO:0001932   regulation of protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
59 356 4din (B) 56 378 37.00 0.00000000042 1 1.07273 1.24
66 355 4din (B) 85 377 60.00 0 1 1.34012 0.45
122 246 3cl1 (A) 226 348 24.00 0 1 0.67114 -0.77
157 243 2ptm (A) 572 647 36.00 0.01 0.73 0.430497 0.69

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126950)

Species Accession Gene Product
Babesia bovis BBOV_II005430   cAMP-dependent protein kinase regulatory subunit, putative
Brugia malayi Bm1_39170   cAMP-dependent protein kinase regulatory chain, putative
Candida albicans CaO19.9565   C. albicans cAMP-dependent protein kinase regulatory subunit
Candida albicans CaO19.2015   allele CaP19.9565 is intact
Caenorhabditis elegans CELE_R07E4.6   Protein KIN-2, isoform C
Cryptosporidium hominis Chro.70024   cAMP-dependent protein kinase regulatory subunit
Cryptosporidium parvum cgd7_120   cAMP-dependent protein kinase regulatory subunit
Chlamydia trachomatis CT_235   cAMP-dependent protein kinase regulatory subunit
Dictyostelium discoideum DDB_G0279413   protein kinase A regulatory subunit
Drosophila melanogaster Dmel_CG15862   cAMP-dependent protein kinase R2
Drosophila melanogaster Dmel_CG42341   cAMP-dependent protein kinase R1
Echinococcus granulosus EgrG_000395400   cAMP dependent protein kinase regulatory subunit type I II alpha beta
Echinococcus granulosus EgrG_000619700   cAMP dependent protein kinase type I beta
Echinococcus granulosus EgrG_001010100   cAMP dependent protein kinase type II regulatory
Echinococcus granulosus EgrG_000775600   cAMP dependent protein kinase regulatory
Echinococcus multilocularis EmuJ_000775600   cAMP dependent protein kinase regulatory
Echinococcus multilocularis EmuJ_000619700   cAMP dependent protein kinase type I beta
Echinococcus multilocularis EmuJ_001010100   cAMP dependent protein kinase type II regulatory
Giardia lamblia GL50803_9117   CAMP-dependent protein kinase regulatory chain
Homo sapiens ENSG00000005249   protein kinase, cAMP-dependent, regulatory, type II, beta
Homo sapiens ENSG00000188191   protein kinase, cAMP-dependent, regulatory, type I, beta
Homo sapiens ENSG00000108946   protein kinase, cAMP-dependent, regulatory, type I, alpha
Homo sapiens ENSG00000114302   protein kinase, cAMP-dependent, regulatory, type II, alpha
Leishmania braziliensis LbrM.13.0150   protein kinase A regulatory subunit, putative
Leishmania donovani LdBPK_130160.1   protein kinase A regulatory subunit
Leishmania infantum LinJ.13.0160   protein kinase A regulatory subunit, putative
Leishmania major LmjF.13.0160   protein kinase A regulatory subunit, putative
Leishmania mexicana LmxM.13.0160   protein kinase A regulatory subunit, putative
Loa Loa (eye worm) LOAG_08516   cAMP-dependent protein kinase regulatory subunit
Mus musculus ENSMUSG00000032601   protein kinase, cAMP dependent regulatory, type II alpha
Mus musculus ENSMUSG00000002997   protein kinase, cAMP dependent regulatory, type II beta
Mus musculus ENSMUSG00000020612   protein kinase, cAMP dependent regulatory, type I, alpha
Mus musculus ENSMUSG00000025855   protein kinase, cAMP dependent regulatory, type I beta
Mycobacterium tuberculosis Rv0104   Conserved hypothetical protein
Neospora caninum NCLIV_017370   CAMP-dependent protein kinase regulatory subunit, putative
Neospora caninum NCLIV_055220   CAMP-dependent protein kinase regulatory subunit, putative
Plasmodium berghei PBANKA_1438000   cAMP-dependent protein kinase regulatory subunit, putative
Plasmodium falciparum PF3D7_1223100   cAMP-dependent protein kinase regulatory subunit
Plasmodium knowlesi PKNH_1442300   cAMP-dependent protein kinase regulatory subunit, putative
Plasmodium vivax PVX_123785   CAMP-dependent protein kinase regulatory subunit, putative
Plasmodium yoelii PY03451   putative cAMP-dependent protein kinase regulatory subunit
Saccharomyces cerevisiae YIL033C   cAMP-dependent protein kinase regulatory subunit BCY1
Schistosoma japonicum Sjp_0302840   ko:K04739 cAMP-dependent protein kinase regulator, putative
Schistosoma japonicum Sjp_0056650   ko:K04739 cAMP-dependent protein kinase regulator, putative
Schistosoma mansoni Smp_030400   camp-dependent protein kinase type I-beta regulatory subunit
Schistosoma mansoni Smp_079010   camp-dependent protein kinase type II-alpha regulatory subunit
Schmidtea mediterranea mk4.016071.00   cAMP-dependent protein kinase type II regulatory subunit
Schmidtea mediterranea mk4.004498.00   cAMP-dependent protein kinase type II regulatory subunit
Schmidtea mediterranea mk4.021422.00   cAMP-dependent protein kinase type II regulatory subunit
Schmidtea mediterranea mk4.002250.04  
Schmidtea mediterranea mk4.001131.03  
Schmidtea mediterranea mk4.003238.00   cAMP-dependent protein kinase type II regulatory subunit
Schmidtea mediterranea mk4.003017.00   cAMP-dependent protein kinase type II regulatory subunit
Schmidtea mediterranea mk4.005824.00  
Schmidtea mediterranea mk4.014515.01  
Schmidtea mediterranea mk4.010897.00   cAMP-dependent protein kinase type II regulatory subunit
Schmidtea mediterranea mk4.001131.02   Camp-dependent protein kinase type I-beta regulatory subunit, putative
Schmidtea mediterranea mk4.005769.04   cAMP-dependent protein kinase regulatory subunit
Schmidtea mediterranea mk4.000719.00   cAMP-dependent protein kinase type II regulatory subunit
Schmidtea mediterranea mk4.003979.00   cAMP-dependent protein kinase type II regulatory subunit
Schmidtea mediterranea mk4.013590.00  
Schmidtea mediterranea mk4.016071.01   cAMP-dependent protein kinase type II regulatory subunit
Schmidtea mediterranea mk4.001030.01   cAMP-dependent protein kinase type II regulatory subunit
Trypanosoma brucei gambiense Tbg972.11.5260   protein kinase A regulatory subunit, putative
Trypanosoma brucei Tb927.11.4610   protein kinase A regulatory subunit
Trypanosoma congolense TcIL3000_0_15340   protein kinase A regulatory subunit
Trypanosoma cruzi TcCLB.506227.150   protein kinase A regulatory subunit
Toxoplasma gondii TGME49_242070   cAMP-dependent protein kinase regulatory subunit
Toxoplasma gondii TGME49_311300   cyclic nucleotide-binding domain-containing protein
Theileria parva TP02_0494   cAMP-dependent protein kinase regulatory subunit, putative
Trichomonas vaginalis TVAG_103080   cAMP-dependent protein kinase type I-beta regulatory subunit, putative
Trichomonas vaginalis TVAG_125340   cAMP-dependent protein kinase regulatory subunit, putative

Essentiality

LOAG_08516 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.2210 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.02.2210 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.02.2210 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.02.2210 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_R07E4.6 Caenorhabditis elegans larval arrest wormbase
CELE_R07E4.6 Caenorhabditis elegans larval lethal wormbase
CELE_R07E4.6 Caenorhabditis elegans sterile wormbase
TGME49_311300 Toxoplasma gondii Probably essential sidik
TGME49_242070 Toxoplasma gondii Probably essential sidik
TGME49_311300 Toxoplasma gondii Probably non-essential sidik
TGME49_242070 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Trypanosoma cruzi protein kinase A regulatory subunit Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier LOAG_08516 (Loa Loa (eye worm)), cAMP-dependent protein kinase regulatory subunit
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