Detailed view for LOAG_06808

Basic information

TDR Targets ID: 940833
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 8.0014 | Length (AA): 425 | MW (Da): 47630 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00650   CRAL/TRIO domain
PF03765   CRAL/TRIO, N-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 370 1olm (A) 33 365 32.00 0 1 1.09253 0.36
4 226 1aua (A) 53 276 31.00 0 1 0.909706 -0.13
5 233 3hx3 (A) 92 306 20.00 0 1 0.818824 -0.7
5 411 4tlg (A) 34 396 28.00 0 1 1.15095 0.41

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126879)

Species Accession Gene Product
Arabidopsis thaliana AT2G16380   Sec14p-like phosphatidylinositol transfer family protein
Arabidopsis thaliana AT4G39180   protein SECRETION 14
Arabidopsis thaliana AT2G18180   Sec14p-like phosphatidylinositol transfer family protein
Arabidopsis thaliana AT2G21540   SEC14-like 3 protein
Arabidopsis thaliana AT4G36490   protein SEC14-like 12
Arabidopsis thaliana AT4G34580   phosphatidylinositol transfer protein COW1
Babesia bovis BBOV_III011520   CRAL/TRIO domain containing protein
Brugia malayi Bm1_23870   SEC14-like protein 4
Brugia malayi Bm1_40055   Hypothetical 84.0 kDa protein T23G5.2 in chromosome III
Candida albicans CaO19.941   likely phosphatidylinositol transfer protein similar to S. cerevisiae SEC14 (YMR079W) involved in Golgi to plasma membrane trans
Candida albicans CaO19.8556   likely phosphatidylinositol transfer protein similar to S. cerevisiae SEC14 (YMR079W) involved in Golgi to plasma membrane trans
Caenorhabditis elegans CELE_T23G5.2   Protein T23G5.2, isoform B
Caenorhabditis elegans CELE_H06O01.3   Protein CTG-1, isoform C
Cryptosporidium hominis Chro.60183   sec14-like CRAL/TRIO domain protein
Cryptosporidium parvum cgd6_1460   SEC14 domain containing protein
Dictyostelium discoideum DDB_G0292832   hypothetical protein
Drosophila melanogaster Dmel_CG9528   real-time
Drosophila melanogaster Dmel_CG13893   CG13893 gene product from transcript CG13893-RA
Echinococcus granulosus EgrG_000818800   SEC14 2 like
Echinococcus multilocularis EmuJ_000818800   conserved hypothetical protein
Homo sapiens ENSG00000100012   SEC14-like 3 (S. cerevisiae)
Homo sapiens ENSG00000129657   SEC14-like 1 (S. cerevisiae)
Homo sapiens ENSG00000100003   SEC14-like 2 (S. cerevisiae)
Homo sapiens ENSG00000103184   SEC14-like 5 (S. cerevisiae)
Leishmania braziliensis LbrM.31.2320   hypothetical protein, conserved
Leishmania braziliensis LbrM.32.1420   hypothetical protein, conserved
Leishmania donovani LdBPK_312100.1   CRAL/TRIO domain containing protein, putative
Leishmania donovani LdBPK_360640.1   sec14, cytosolic factor
Leishmania infantum LinJ.31.2100   hypothetical protein, conserved
Leishmania infantum LinJ.36.0640   sec14, cytosolic factor
Leishmania major LmjF.31.2060   hypothetical protein, conserved
Leishmania mexicana LmxM.30.2060   hypothetical protein, conserved
Leishmania mexicana LmxM.36.0581   sec14, cytosolic factor
Loa Loa (eye worm) LOAG_06808   hypothetical protein
Loa Loa (eye worm) LOAG_10616   hypothetical protein
Loa Loa (eye worm) LOAG_07425   hypothetical protein
Loa Loa (eye worm) LOAG_07424   CTG-1 protein
Mus musculus 380683   SEC14-like 3 (S. cerevisiae)
Mus musculus ENSMUSG00000091712   SEC14-like 5 (S. cerevisiae)
Mus musculus ENSMUSG00000020823   SEC14-like 1 (S. cerevisiae)
Mus musculus ENSMUSG00000003585   SEC14-like 2 (S. cerevisiae)
Oryza sativa 4328209   Os02g0133200
Oryza sativa 4348005   Os10g0122600
Oryza sativa 4329236   Os02g0440900
Saccharomyces cerevisiae YMR079W   phosphatidylinositol/phosphatidylcholine transfer protein SEC14
Schistosoma japonicum Sjp_0022690   SEC14-like protein 2, putative
Schistosoma mansoni Smp_159400   phospholipid transport protein
Schistosoma mansoni Smp_192650   phospholipid transport protein
Schmidtea mediterranea mk4.013856.01  
Schmidtea mediterranea mk4.010120.01   Phospholipid transport protein
Schmidtea mediterranea mk4.017158.00  
Schmidtea mediterranea mk4.017158.01  
Schmidtea mediterranea mk4.022756.00   Phospholipid transport protein
Schmidtea mediterranea mk4.013856.00  
Trypanosoma cruzi TcCLB.510293.20   cytosolic factor SEC14, putative
Trypanosoma cruzi TcCLB.506583.70   phosphatidylinositol/phosphatidylcholine transfer protein, putative
Trypanosoma cruzi TcCLB.507507.49   hypothetical protein, conserved
Theileria parva TP02_0781   hypothetical protein

Essentiality

LOAG_06808 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
YMR079W Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_06808 (Loa Loa (eye worm)), hypothetical protein
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