Detailed view for LOAG_00927

Basic information

TDR Targets ID: 941603
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 6.7341 | Length (AA): 1007 | MW (Da): 116154 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01074   Glycosyl hydrolases family 38 N-terminal domain
PF07748   Glycosyl hydrolases family 38 C-terminal domain
PF09261   Alpha mannosidase middle domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0030246   carbohydrate binding  
GO:0004559   alpha-mannosidase activity  
GO:0003824   catalytic activity  
GO:0006013   mannose metabolic process  
GO:0005975   carbohydrate metabolic process  

Metabolic Pathways

N-Glycan biosynthesis (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
24 135 5tpt (A) 468 569 16.00 0 0.06 0.233421 -1.21
26 158 2i1k (A) 338 493 13.00 0.53 0.04 0.307475 -0.79
47 133 4tql (A) 120 217 34.00 0.018 0.28 0.331795 -0.86
181 1007 3bvx (A) 30 860 37.00 0 1 1.26165 -0.28
191 1007 3bvx (A) 40 860 44.00 0 1 1.28972 -0.37

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130088)

Species Accession Gene Product
Arabidopsis thaliana AT5G14950   alpha-mannosidase II
Brugia malayi Bm1_29570   Glycosyl hydrolases family 38 protein
Caenorhabditis elegans CELE_F58H1.1   Protein AMAN-2
Dictyostelium discoideum DDB_G0287231   hypothetical protein
Dictyostelium discoideum DDB_G0278259   hypothetical protein
Dictyostelium discoideum DDB_G0268994   hypothetical protein
Dictyostelium discoideum DDB_G0278651   hypothetical protein
Dictyostelium discoideum DDB_G0278653   hypothetical protein
Drosophila melanogaster Dmel_CG4606   CG4606 gene product from transcript CG4606-RA
Drosophila melanogaster Dmel_CG18802   alpha Mannosidase II
Echinococcus granulosus EgrG_000097600   alpha mannosidase 2
Echinococcus granulosus EgrG_002002600   alpha mannosidase 2
Echinococcus multilocularis EmuJ_000097600   alpha mannosidase 2
Homo sapiens 4124   mannosidase, alpha, class 2A, member 1
Homo sapiens ENSG00000196547   mannosidase, alpha, class 2A, member 2
Loa Loa (eye worm) LOAG_00927   hypothetical protein
Loa Loa (eye worm) LOAG_12461   hypothetical protein
Mus musculus ENSMUSG00000024085   mannosidase 2, alpha 1
Mus musculus ENSMUSG00000038886   mannosidase 2, alpha 2
Oryza sativa 4340636   Os06g0245700
Schistosoma japonicum Sjp_0201940   Alpha-mannosidase 2, putative
Schistosoma japonicum Sjp_0201920   Alpha-mannosidase 2, putative
Schistosoma japonicum Sjp_0201930   Alpha-mannosidase 2, putative
Schistosoma mansoni Smp_143430   mannosidase alpha class 2a
Schmidtea mediterranea mk4.017289.01   Alpha-mannosidase 2
Schmidtea mediterranea mk4.052918.00   Alpha-mannosidase 2
Schmidtea mediterranea mk4.016141.01   Alpha-mannosidase 2
Schmidtea mediterranea mk4.017289.02   Alpha-mannosidase 2
Schmidtea mediterranea mk4.017289.00   Alpha-mannosidase 2

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens mannosidase, alpha, class 2A, member 1 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Canavalia ensiformis Alpha-mannosidase 981 aa 25.7% 818 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0215 1 1
0.008 1 1
0.0453 0.5846 0.5331
0.008 1 1
0.0065 0.289 1
0.0116 0.3867 0.3867
0.0216 0.4711 0.4487
0.0066 0.2883 0.4967
0.0217 0.3758 1
0.008 1 1
0.008 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_00927 (Loa Loa (eye worm)), hypothetical protein
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