pI: 10.2717 |
Length (AA): 126 |
MW (Da): 14677 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
25 | 84 | 4tql (A) | 89 | 151 | 18.00 | 0.031 | 0.07 | 0.72669 | -1.32 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_130122)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G06660 | hypothetical protein |
Arabidopsis thaliana | AT3G12030 | hypothetical protein |
Babesia bovis | BBOV_IV002080 | hypothetical protein |
Brugia malayi | Bm1_16235 | hypothetical protein |
Caenorhabditis elegans | CELE_F22B5.10 | Protein F22B5.10 |
Cryptosporidium hominis | Chro.60186 | dbj |
Cryptosporidium parvum | cgd6_1490 | dbj |
Dictyostelium discoideum | DDB_G0281489 | hypothetical protein |
Drosophila melanogaster | Dmel_CG10470 | CG10470 gene product from transcript CG10470-RA |
Echinococcus granulosus | EgrG_000703900 | protein of unknown function DUF841 eukaryotic |
Entamoeba histolytica | EHI_177610 | hypothetical protein, conserved |
Echinococcus multilocularis | EmuJ_000703900 | protein of unknown function DUF841, eukaryotic |
Homo sapiens | ENSG00000143183 | transmembrane and coiled-coil domains 1 |
Loa Loa (eye worm) | LOAG_14121 | transmembrane and coiled-coil domains 1 |
Loa Loa (eye worm) | LOAG_06225 | TU37B2 |
Mus musculus | ENSMUSG00000052428 | transmembrane and coiled-coil domains 1 |
Neospora caninum | NCLIV_068820 | hypothetical protein |
Oryza sativa | 4333937 | Os03g0721400 |
Onchocerca volvulus | OVOC13485 |
|
Plasmodium berghei | PBANKA_1138300 | conserved protein, unknown function |
Plasmodium falciparum | PF3D7_1362300 | conserved protein, unknown function |
Plasmodium knowlesi | PKNH_1109000 | conserved protein, unknown function |
Plasmodium vivax | PVX_115070 | hypothetical protein, conserved |
Plasmodium yoelii | PY00975 | Arabidopsis thaliana At5g06660/F15M7_19, putative |
Schistosoma japonicum | Sjp_0003090 | Transmembrane and coiled-coil domains protein 1, putative |
Schmidtea mediterranea | mk4.001166.05 | Tmco1 protein |
Toxoplasma gondii | TGME49_310870 | integral membrane protein, putative |
Theileria parva | TP03_0444 | hypothetical protein, conserved |
Trichomonas vaginalis | TVAG_070920 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_477310 | transmembrane and coiled-coil domains protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
TGME49_310870 | Toxoplasma gondii | Probably non-essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.