Detailed view for LOAG_07962

Basic information

TDR Targets ID: 942368
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 6.7191 | Length (AA): 659 | MW (Da): 73552 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF12796   Ankyrin repeats (3 copies)
PF13920   Zinc finger, C3HC4 type (RING finger)

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 10 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
12 107 1ihb (A) 38 128 8.00 0.0001 0.04 0.179675 -0.22
16 107 3aaa (C) 7 93 11.00 0.0000064 0.18 0.230605 -0.35
74 394 5y4d (A) 2180 2476 26.00 0.0000000043 1 0.586102 0.88
270 389 5oyj (A) 44 153 34.00 0.000000037 1 0.607094 -0.88
310 391 2b0o (G) 589 664 25.00 0 1 0.313731 -0.3
495 544 2ecg (A) 27 73 45.00 0.00064 0.98 0.470873 0.8
592 655 4ayc (A) 382 448 31.00 0.55 0.89 0.467117 -0.33
603 658 4auq (B) 242 296 42.00 0.000017 1 0.528977 0.13
610 651 2ma6 (A) 8 52 45.00 0.21 0.98 0.507733 0.21
611 654 2ea6 (A) 16 69 41.00 0.78 0.55 0.218768 0.8

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130493)

Species Accession Gene Product
Brugia malayi Bm1_01310   hypothetical protein
Caenorhabditis elegans CELE_Y47D3A.22   Protein MIB-1
Drosophila melanogaster Dmel_CG5841   mind bomb 1
Drosophila melanogaster Dmel_CG17492   mind bomb 2
Echinococcus granulosus EgrG_000694800   mind bomb
Echinococcus multilocularis EmuJ_000694800   mind bomb
Homo sapiens ENSG00000197530   mindbomb E3 ubiquitin protein ligase 2
Homo sapiens ENSG00000101752   mindbomb E3 ubiquitin protein ligase 1
Loa Loa (eye worm) LOAG_07962   hypothetical protein
Mus musculus ENSMUSG00000024294   mindbomb homolog 1 (Drosophila)
Mus musculus ENSMUSG00000029060   mindbomb homolog 2 (Drosophila)
Schistosoma japonicum Sjp_0115540   ko:K10645 E3 ubiquitin-protein ligase MIB1, putative
Schistosoma mansoni Smp_171440   mind bomb
Schmidtea mediterranea mk4.001195.00  
Schmidtea mediterranea mk4.004874.02  
Schmidtea mediterranea mk4.000333.03  
Schmidtea mediterranea mk4.011177.00  
Schmidtea mediterranea mk4.004993.01  
Schmidtea mediterranea mk4.017935.00  
Schmidtea mediterranea mk4.002198.00  
Schmidtea mediterranea mk4.005671.07  
Schmidtea mediterranea mk4.007349.00   E3 ubiquitin-protein ligase MIB2
Schmidtea mediterranea mk4.018386.01   E3 ubiquitin-protein ligase MIB2
Schmidtea mediterranea mk4.006238.00  
Schmidtea mediterranea mk4.030677.00  
Schmidtea mediterranea mk4.002738.03  
Schmidtea mediterranea mk4.002335.00  
Schmidtea mediterranea mk4.006105.03  
Schmidtea mediterranea mk4.012230.00  
Schmidtea mediterranea mk4.029299.00  
Schmidtea mediterranea mk4.001597.01  
Schmidtea mediterranea mk4.006616.00  
Schmidtea mediterranea mk4.027184.00  
Schmidtea mediterranea mk4.008061.00   E3 ubiquitin-protein ligase MIB1
Schmidtea mediterranea mk4.021775.02   E3 ubiquitin-protein ligase MIB2
Schmidtea mediterranea mk4.011757.02  
Schmidtea mediterranea mk4.004591.05  
Schmidtea mediterranea mk4.006279.00  
Schmidtea mediterranea mk4.018848.00  
Schmidtea mediterranea mk4.000477.23   E3 ubiquitin-protein ligase MIB2
Schmidtea mediterranea mk4.033008.00  
Schmidtea mediterranea mk4.030278.00   E3 ubiquitin-protein ligase MIB2

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_07962 (Loa Loa (eye worm)), hypothetical protein
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