Detailed view for LOAG_06298

Basic information

TDR Targets ID: 942536
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 9.0343 | Length (AA): 536 | MW (Da): 61438 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01150   GDA1/CD39 (nucleoside phosphatase) family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016787   hydrolase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
40 475 3cj1 (A) 36 460 22.00 0 1 1.06133 -0.2
42 464 5u7w (A) 5 409 25.00 0 1 1.07808 -0.31
43 431 5u7x (F) 6 370 32.00 0 1 0.943546 0.33
43 458 3zx3 (A) 48 458 26.00 0 1 1.01292 -0.39

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130333)

Species Accession Gene Product
Arabidopsis thaliana AT2G02970   probable apyrase 6
Brugia malayi Bm1_40650   Nucleoside-diphosphatase mig-23
Candida albicans CaO19.10432   Nucleoside Diphosphatase: apyrase (NDPase/NTPase)
Candida albicans CaO19.2915   Nucleoside Diphosphatase: apyrase (NDPase/NTPase)
Caenorhabditis elegans CELE_C33H5.14   Protein NTP-1
Caenorhabditis elegans CELE_R07E4.4   Protein MIG-23
Echinococcus granulosus EgrG_000614100   ectonucleoside triphosphate diphosphohydrolase
Echinococcus multilocularis EmuJ_000614100   ectonucleoside triphosphate diphosphohydrolase
Homo sapiens 57089   ectonucleoside triphosphate diphosphohydrolase 7
Homo sapiens ENSG00000197217   ectonucleoside triphosphate diphosphohydrolase 4
Loa Loa (eye worm) LOAG_06298   hypothetical protein
Mus musculus ENSMUSG00000025192   ectonucleoside triphosphate diphosphohydrolase 7
Mus musculus ENSMUSG00000022066   predicted gene, 21685
Mus musculus ENSMUSG00000095463   ectonucleoside triphosphate diphosphohydrolase 4
Saccharomyces cerevisiae YER005W   Ynd1p
Schistosoma japonicum Sjp_0106090   ko:K01511 nucleoside-diphosphatase [EC3.6.1.6], putative
Schistosoma japonicum Sjp_0305100   ko:K01511 nucleoside-diphosphatase [EC3.6.1.6], putative
Schistosoma mansoni Smp_166520   guanosine-diphosphatase
Schmidtea mediterranea mk4.055639.00   Guanosine-diphosphatase, putative
Schmidtea mediterranea mk4.000467.04   Guanosine-diphosphatase, putative
Schmidtea mediterranea mk4.018393.00   Guanosine-diphosphatase, putative
Schmidtea mediterranea mk4.034558.00   Guanosine-diphosphatase, putative
Schmidtea mediterranea mk4.002668.03  
Schmidtea mediterranea mk4.013996.00   Guanosine-diphosphatase, putative
Schmidtea mediterranea mk4.001999.05   Guanosine-diphosphatase, putative
Schmidtea mediterranea mk4.002668.02   Guanosine-diphosphatase, putative
Schmidtea mediterranea mk4.002231.01   Guanosine-diphosphatase, putative
Schmidtea mediterranea mk4.032468.00   Guanosine-diphosphatase, putative
Schmidtea mediterranea mk4.033199.00   Guanosine-diphosphatase, putative
Schmidtea mediterranea mk4.000338.05   Guanosine-diphosphatase, putative
Schmidtea mediterranea mk4.025686.00   Guanosine-diphosphatase, putative
Schmidtea mediterranea mk4.002668.01   Guanosine-diphosphatase, putative
Schmidtea mediterranea mk4.015005.00   Guanosine-diphosphatase, putative
Schmidtea mediterranea mk4.039209.01   Guanosine-diphosphatase, putative
Schmidtea mediterranea mk4.006696.02   Guanosine-diphosphatase, putative
Schmidtea mediterranea mk4.007476.02   Guanosine-diphosphatase, putative
Schmidtea mediterranea mk4.005772.00   Guanosine-diphosphatase, putative
Schmidtea mediterranea mk4.021451.01   Guanosine-diphosphatase, putative
Schmidtea mediterranea mk4.029231.02   Guanosine-diphosphatase, putative
Schmidtea mediterranea mk4.003923.00   Guanosine-diphosphatase, putative
Trichomonas vaginalis TVAG_167570   adenosine diphosphatase, putative
Trichomonas vaginalis TVAG_063220   guanosine-diphosphatase, putative

Essentiality

LOAG_06298 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
YER005W Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bos taurus Ectonucleoside triphosphate diphosphohydrolase 1 513 aa 23.6% 534 aa Compounds References
Rattus norvegicus Nucleoside triphosphate diphosphohydrolase 3 529 aa 25.8% 503 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0027 0.2563 0.5624
0.0037 0.2556 0.5614

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_06298 (Loa Loa (eye worm)), hypothetical protein
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