Detailed view for LOAG_11173

Basic information

TDR Targets ID: 943276
Loa Loa (eye worm), transcription factor IIA
Source Database / ID:  KEGG  

pI: 4.5758 | Length (AA): 409 | MW (Da): 44908 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03153   Transcription factor IIA, alpha/beta subunit

Gene Ontology

Mouse over links to read term descriptions.
GO:0005672   transcription factor TFIIA complex  
GO:0006367   transcription initiation from RNA polymerase II promoter  

Metabolic Pathways

Basal transcription factors (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
10 52 1nvp (B) 9 51 49.00 0.000019 1 0.845334 -1.62
66 364 4k6j (A) 790 1146 12.00 0 0.03 0.793251 -0.15
279 409 5m4s (A) 82 210 37.00 0 0.97 0.679493 0.56
348 409 1rm1 (C) 55 285 40.00 0.0000001 0.77 0.549789 0.67

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129497)

Species Accession Gene Product
Arabidopsis thaliana AT1G07480   transcription factor IIA, alpha/beta subunit
Arabidopsis thaliana AT5G59230   transcription factor-related protein
Arabidopsis thaliana AT1G07470   transcription factor IIA, alpha/beta subunit
Brugia malayi Bm1_00860   Transcription factor IIA, alpha/beta subunit family protein
Candida albicans CaO19.10197   RNA pol II transcription initiation factor TFIIA
Candida albicans CaO19.2682   RNA pol II transcription initiation factor TFIIA
Caenorhabditis elegans CELE_K11D12.2   Protein PQN-51
Dictyostelium discoideum DDB_G0290327   transcription factor IIA, large chain
Drosophila melanogaster Dmel_CG5930   Transcription factor IIA L
Echinococcus granulosus EgrG_000555800   tfiia large subunit
Echinococcus granulosus EgrG_000555400   tfiia large subunit
Echinococcus multilocularis EmuJ_000555800   tfiia large subunit
Echinococcus multilocularis EmuJ_000555400   tfiia large subunit
Homo sapiens ENSG00000165417   general transcription factor IIA, 1, 19/37kDa
Loa Loa (eye worm) LOAG_11173   transcription factor IIA
Mus musculus ENSMUSG00000020962   general transcription factor II A, 1
Oryza sativa 4338303   Os05g0292200
Saccharomyces cerevisiae YOR194C   Toa1p
Schistosoma japonicum Sjp_0312490   ko:K03122 transcription initiation factor TFIIA large subunit, putative
Schistosoma japonicum Sjp_0086070   IPR004855,Transcription factor IIA, alpha/beta subunit;IPR009083,Transcription factor IIA, helical;IPR009088,Transcription facto
Schistosoma mansoni Smp_080280.2   tfiia large subunit
Schistosoma mansoni Smp_080280.3   tfiia large subunit

Essentiality

LOAG_11173 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_K11D12.2 Caenorhabditis elegans embryonic lethal wormbase
YOR194C Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens general transcription factor IIA, 1, 19/37kDa Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_11173 (Loa Loa (eye worm)), transcription factor IIA
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