Detailed view for LOAG_08243

Basic information

TDR Targets ID: 943477
Loa Loa (eye worm), transcription initiation factor IID
Source Database / ID:  KEGG  

pI: 4.736 | Length (AA): 172 | MW (Da): 19949 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02291   Transcription initiation factor IID, 31kD subunit

Gene Ontology

Mouse over links to read term descriptions.
GO:0046982   protein heterodimerization activity  
GO:0006352   transcription initiation  

Metabolic Pathways

Basal transcription factors (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 111 6f3t (F) 11 120 51.00 0 1 1.17082 0.22
5 71 1taf (A) 19 85 51.00 0 1 1.09053 -1.32

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128485)

Species Accession Gene Product
Arabidopsis thaliana AT1G54140   TATA binding protein associated factor subunit 21
Brugia malayi Bm1_21065   transcription initiation factor IID, 31kD subunit, putative
Candida albicans CaO19.8708   TFIID subunit
Candida albicans CaO19.1111   general RNA polymerase II transcription factor
Caenorhabditis elegans CELE_T12D8.7   Protein TAF-9
Dictyostelium discoideum DDB_G0272360   TFIID subunit
Drosophila melanogaster Dmel_CG6474   enhancer of yellow 1
Echinococcus granulosus EgrG_000816500   transcription initiation factor tfiid subunit 9
Entamoeba histolytica EHI_095080   hypothetical protein
Echinococcus multilocularis EmuJ_000816500   transcription initiation factor tfiid subunit 9
Homo sapiens ENSG00000187325   TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
Homo sapiens ENSG00000273841   TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
Loa Loa (eye worm) LOAG_08243   transcription initiation factor IID
Mus musculus ENSMUSG00000047242   TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor
Mus musculus ENSMUSG00000052293   TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor
Oryza sativa 4333084   Os03g0408500
Oryza sativa 4343878   Os07g0612500
Saccharomyces cerevisiae YMR236W   TATA-binding protein-associated factor TAF9
Schistosoma japonicum Sjp_0019630   ko:K03133 transcription initiation factor TFIID subunit D7, putative
Schistosoma mansoni Smp_166980   hypothetical protein
Trichomonas vaginalis TVAG_149520   tafii32, putative

Essentiality

LOAG_08243 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_T12D8.7 Caenorhabditis elegans embryonic arrest wormbase
CELE_T12D8.7 Caenorhabditis elegans embryonic lethal wormbase
CELE_T12D8.7 Caenorhabditis elegans slow growth wormbase
YMR236W Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_08243 (Loa Loa (eye worm)), transcription initiation factor IID
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