Detailed view for LOAG_08058

Basic information

TDR Targets ID: 943503
Loa Loa (eye worm), ribosomal protein L27
Source Database / ID:  KEGG  

pI: 11.2889 | Length (AA): 136 | MW (Da): 15627 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00467   KOW motif
PF01777   Ribosomal L27e protein family

Gene Ontology

Mouse over links to read term descriptions.
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127262)

Species Accession Gene Product
Arabidopsis thaliana AT3G22230   60S ribosomal protein L27-2
Arabidopsis thaliana AT4G15000   60S ribosomal protein L27-3
Arabidopsis thaliana AT2G32220   60S ribosomal protein L27-1
Babesia bovis BBOV_III010680   ribosomal L27e protein family protein
Brugia malayi Bm1_28975   60S ribosomal protein L27
Caenorhabditis elegans CELE_C53H9.1   Protein RPL-27
Cryptosporidium hominis Chro.10333   ribosomal protein L27
Cryptosporidium parvum cgd1_3000   60S ribosomal protein L27
Dictyostelium discoideum DDB_G0271298   S60 ribosomal protein L27
Drosophila melanogaster Dmel_CG4759   Ribosomal protein L27
Echinococcus granulosus EgrG_000724800   60S ribosomal protein L27
Entamoeba histolytica EHI_183480   60S ribosomal protein L27, putative
Entamoeba histolytica EHI_146370   60S ribosomal protein L27, putative
Echinococcus multilocularis EmuJ_000724800   60S ribosomal protein L27
Giardia lamblia GL50803_8462   Ribosomal protein L27
Homo sapiens ENSG00000131469   ribosomal protein L27
Leishmania braziliensis LbrM.32.2930   ribosomal protein L27, putative
Leishmania braziliensis LbrM.32.2950   ribosomal protein L27, putative
Leishmania donovani LdBPK_322850.1   ribosomal protein L27, putative
Leishmania donovani LdBPK_322830.1   ribosomal protein L27, putative
Leishmania infantum LinJ.32.2850   ribosomal protein L27, putative
Leishmania infantum LinJ.32.2830   ribosomal protein L27, putative
Leishmania major LmjF.32.2690   ribosomal protein L27, putative
Leishmania major LmjF.32.2710   ribosomal protein L27, putative
Leishmania mexicana LmxM.31.2690   ribosomal protein L27, putative
Loa Loa (eye worm) LOAG_08058   ribosomal protein L27
Mus musculus ENSMUSG00000063316   ribosomal protein L27
Neospora caninum NCLIV_025160   hypothetical protein
Oryza sativa 4329034   Os02g0284600
Oryza sativa 4349409   Os10g0564300
Onchocerca volvulus OVOC13421  
Plasmodium berghei PBANKA_1324400   60S ribosomal protein L27, putative
Plasmodium falciparum PF3D7_1460700   60S ribosomal protein L27
Plasmodium knowlesi PKNH_1221000   60S ribosomal protein L27, putative
Plasmodium vivax PVX_117420   60S ribosomal protein L27, putative
Plasmodium yoelii PY01750   60S ribosomal protein L27 homolog
Saccharomyces cerevisiae YHR010W   ribosomal 60S subunit protein L27A
Saccharomyces cerevisiae YDR471W   ribosomal 60S subunit protein L27B
Schistosoma japonicum Sjp_0011460   ko:K02901 large subunit ribosomal protein L27e, putative
Schistosoma mansoni Smp_063350   60S ribosomal protein L27e
Schmidtea mediterranea mk4.002567.08   60S ribosomal protein L27
Schmidtea mediterranea mk4.001433.00   60S ribosomal protein L27
Trypanosoma brucei gambiense Tbg972.11.17830   60S ribosomal protein L27, putative
Trypanosoma brucei gambiense Tbg972.11.17810   60S ribosomal protein L27, putative
Trypanosoma brucei Tb927.11.15900   60S ribosomal protein L27, putative
Trypanosoma brucei Tb927.11.15880   60S ribosomal protein L27, putative
Trypanosoma cruzi TcCLB.511545.20   ribosomal protein L27, putative
Trypanosoma cruzi TcCLB.511545.40   ribosomal protein L27, putative
Trypanosoma cruzi TcCLB.506817.30   ribosomal protein L27, putative
Trypanosoma cruzi TcCLB.506817.50   ribosomal protein L27, putative
Toxoplasma gondii TGME49_262690   ribosomal protein RPL27
Theileria parva TP02_0078   60S ribosomal protein L27e, putative
Trichomonas vaginalis TVAG_302830   60S ribosomal protein L27e, putative
Trichomonas vaginalis TVAG_189070   60S ribosomal protein L27e, putative
Trichomonas vaginalis TVAG_380870   60S ribosomal protein L27e, putative
Trichomonas vaginalis TVAG_306310   60S ribosomal protein L27e, putative
Trichomonas vaginalis TVAG_337950   60S ribosomal protein L27e, putative
Trichomonas vaginalis TVAG_140290   60S ribosomal protein L27e, putative
Trichomonas vaginalis TVAG_215980   60S ribosomal protein L27e, putative

Essentiality

LOAG_08058 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.7535 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.01.7535 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.7535 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.01.7535 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C53H9.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_C53H9.1 Caenorhabditis elegans larval arrest wormbase
CELE_C53H9.1 Caenorhabditis elegans slow growth wormbase
TGME49_262690 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier LOAG_08058 (Loa Loa (eye worm)), ribosomal protein L27
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