Detailed view for LOAG_06419

Basic information

TDR Targets ID: 943880
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 8.9979 | Length (AA): 367 | MW (Da): 40929 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01926   50S ribosome-binding GTPase
PF02824   TGS domain
PF16897   C-terminal region of MMR_HSR1 domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005525   GTP binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 367 4a9a (A) 3 369 44.00 0 1 1.44488 0.32
3 367 4a9a (A) 4 369 53.00 0 1 1.58465 -0.28

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128226)

Species Accession Gene Product
Arabidopsis thaliana AT1G17470   developmentally regulated G-protein 1
Arabidopsis thaliana AT1G72660   developmentally regulated G-protein 2
Babesia bovis BBOV_I003460   GTP binding protein, putative
Brugia malayi Bm1_53710   Hypothetical GTP-binding protein C02F5.3 in chromosome III
Candida albicans CaO19.3977   probable GTP-binding protein
Candida albicans CaO19.11460   probable GTP-binding protein
Caenorhabditis elegans CELE_C02F5.3   Protein C02F5.3
Cryptosporidium hominis Chro.30022   developmentally regulated GTP-binding protein 2
Cryptosporidium parvum cgd3_130   DRG like OBG family GTpase fused to an RNA binding domain TGS domain, Fun11p
Dictyostelium discoideum DDB_G0279451   hypothetical protein
Drosophila melanogaster Dmel_CG6195   CG6195 gene product from transcript CG6195-RA
Echinococcus granulosus EgrG_000585000   Developmentally regulated GTP binding protein 2
Echinococcus multilocularis EmuJ_000585000   Developmentally regulated GTP binding protein 2
Giardia lamblia GL50803_5871   Developmentally regulated GTP-binding protein 1
Homo sapiens ENSG00000108591   developmentally regulated GTP binding protein 2
Leishmania braziliensis LbrM.34.5250   GTP-binding protein, putative
Leishmania donovani LdBPK_355280.1   GTP-binding protein, putative
Leishmania infantum LinJ.35.5280   GTP-binding protein, putative
Leishmania major LmjF.35.5310   GTP-binding protein, putative
Leishmania mexicana LmxM.34.5310   GTP-binding protein, putative
Loa Loa (eye worm) LOAG_06419   hypothetical protein
Mus musculus ENSMUSG00000020537   developmentally regulated GTP binding protein 2
Neospora caninum NCLIV_033060   hypothetical protein
Oryza sativa 4338525   Os05g0357600
Onchocerca volvulus OVOC9372  
Plasmodium berghei PBANKA_1135200   GTP-binding protein, putative
Plasmodium falciparum PF3D7_1358900   GTP-binding protein, putative
Plasmodium knowlesi PKNH_1112400   GTP-binding protein, putative
Plasmodium vivax PVX_114920   GTP-binding protein, putative
Plasmodium yoelii PY03928   developmentally regulated GTP-binding protein 2
Saccharomyces cerevisiae YGR173W   Rbg2p
Schistosoma japonicum Sjp_0032590   ko:K06944 DRG2; developmentally regulated GTP binding protein 2, putative
Schistosoma mansoni Smp_080550   developmentally regulated GTP-binding protein 2 (drg 2)
Schmidtea mediterranea mk4.003450.03   Putative developmentally regulated GTP-binding protein 2
Schmidtea mediterranea mk4.005106.05   Putative developmentally regulated GTP-binding protein 2
Trypanosoma brucei gambiense Tbg972.9.5000   developmentally regulated GTP-binding protein, putative
Trypanosoma brucei Tb927.9.9020   ribosome-interacting GTPase 2, putative
Trypanosoma cruzi TcCLB.506883.30   ribosome-interacting GTPase 2, putative
Toxoplasma gondii TGME49_233260   GTP-binding protein, putative
Trichomonas vaginalis TVAG_123550   developmentally regulated GTP-binding protein, putative

Essentiality

LOAG_06419 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.211.0720 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb09.211.0720 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb09.211.0720 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb09.211.0720 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_233260 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_06419 (Loa Loa (eye worm)), hypothetical protein
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