Detailed view for LOAG_03851

Basic information

TDR Targets ID: 944182
Loa Loa (eye worm), ATP-binding cassette
Source Database / ID:  KEGG  

pI: 6.7472 | Length (AA): 659 | MW (Da): 73967 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00005   ABC transporter
PF12848   ABC transporter

Gene Ontology

Mouse over links to read term descriptions.
GO:0016887   ATPase activity  
GO:0005524   ATP binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
24 233 3cmu (A) 284 1186 32.00 0.19 0.88 0.185065 1.63
26 95 3fw2 (A) 247 324 31.00 0.69 0.57 0.337622 -0.43
79 336 4f4c (A) 382 630 22.00 0.00000065 0.95 0.569702 0.47
110 652 5zxd (A) 2 539 68.00 0 1 1.44038 -0.25
439 645 4rvc (A) 2 224 26.00 0.0000000017 1 0.651312 -0.97
544 621 3pih (A) 451 533 38.00 0.051 0.99 0.579761 -0.51

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129638)

Species Accession Gene Product
Arabidopsis thaliana AT3G54540   ABC transporter F family member 4
Brugia malayi Bm1_33430   ATP-binding cassette, sub-family F
Caenorhabditis elegans CELE_F18E2.2   Protein ABCF-1
Dictyostelium discoideum DDB_G0267436   hypothetical protein
Drosophila melanogaster Dmel_CG1703   CG1703 gene product from transcript CG1703-RB
Echinococcus granulosus EgrG_000523700   ATP binding cassette sub family F
Entamoeba histolytica EHI_047760   ATP-binding cassette protein, putative
Echinococcus multilocularis EmuJ_000523700   ATP binding cassette sub family F
Homo sapiens ENSG00000204574   ATP-binding cassette, sub-family F (GCN20), member 1
Leishmania braziliensis LbrM.33.0320   ATP-binding cassette protein, putative
Leishmania donovani LdBPK_330340.1   ATP-binding cassette sub-family F member 1, putative
Leishmania infantum LinJ.33.0340   ATP-binding cassette protein subfamily F, member 3, putative
Leishmania major LmjF.33.0310   ATP-binding cassette protein subfamily F, member 3, putative
Leishmania mexicana LmxM.32.0310   ATP-binding cassette protein, putative
Loa Loa (eye worm) LOAG_03851   ATP-binding cassette
Mus musculus ENSMUSG00000038762   ATP-binding cassette, sub-family F (GCN20), member 1
Oryza sativa 4333216   Os03g0441500
Schistosoma japonicum Sjp_0068000   ko:K06184 ATP-binding cassette, sub-family F, member 1, putative
Schistosoma mansoni Smp_166040   ATP-dependent transporter
Schmidtea mediterranea mk4.003552.04   ATP-binding cassette sub-family F member 1
Schmidtea mediterranea mk4.000914.04  
Schmidtea mediterranea mk4.000210.18  
Trypanosoma brucei gambiense Tbg972.10.13240   ATP-binding cassette protein, putative,ABC transporter, putative,ATPase, putative
Trypanosoma brucei Tb927.10.10880   ATP-binding cassette sub-family F member 1, putative
Trypanosoma congolense TcIL3000_10_9180   ATP-binding cassette sub-family F member 1, putative
Trypanosoma cruzi TcCLB.509105.130   ATP-binding cassette sub-family F member 1, putative

Essentiality

LOAG_03851 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.10880 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.10880 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.10880 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.10880 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F18E2.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_F18E2.2 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_03851 (Loa Loa (eye worm)), ATP-binding cassette
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