Detailed view for LOAG_12367

Basic information

TDR Targets ID: 944224
Loa Loa (eye worm), ab-hydrolase associated lipase region family protein
Source Database / ID:  KEGG  

pI: 7.9324 | Length (AA): 389 | MW (Da): 44537 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00561   alpha/beta hydrolase fold
PF04083   Partial alpha/beta-hydrolase lipase region

Gene Ontology

Mouse over links to read term descriptions.
GO:0016788   hydrolase activity, acting on ester bonds  
GO:0006629   lipid metabolic process  

Metabolic Pathways

Steroid biosynthesis (KEGG)
Lysosome (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 385 1k8q (A) 14 377 38.00 0 1 1.48582 -1.1
1 386 1hlg (A) 14 378 41.00 0 1 1.49679 -0.73

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126861)

Species Accession Gene Product
Arabidopsis thaliana AT5G14180   Myzus persicae-induced lipase 1
Arabidopsis thaliana AT2G15230   triacylglycerol lipase 1
Brugia malayi Bm1_21635   ab-hydrolase associated lipase region family protein
Candida albicans CaO19.9598   triglyceride lipase-cholesterol esterase
Candida albicans CaO19.2050   triglyceride lipase-cholesterol esterase
Candida albicans CaO19.12449   second version of TGL1, triglyceride lipase-cholesterol esterase
Candida albicans CaO19.4982   second version of TGL1, triglyceride lipase-cholesterol esterase
Caenorhabditis elegans CELE_Y57E12B.10   Protein Y57E12B.10
Caenorhabditis elegans CELE_R11G11.14   Protein LIPL-3
Caenorhabditis elegans CELE_Y57E12B.3   Protein LIPL-6
Caenorhabditis elegans CELE_F54F3.3   Protein LIPL-1
Caenorhabditis elegans CELE_ZK6.7   Protein LIPL-5, isoform B
Caenorhabditis elegans CELE_F01G10.7   Protein LIPL-7
Dictyostelium discoideum DDB_G0268964   hypothetical protein
Dictyostelium discoideum DDB_G0268740   carboxylic ester hydrolase
Dictyostelium discoideum DDB_G0277723   carboxylic ester hydrolase
Dictyostelium discoideum DDB_G0276083   carboxylic ester hydrolase
Dictyostelium discoideum DDB_G0268966   hypothetical protein
Drosophila melanogaster Dmel_CG18302   CG18302 gene product from transcript CG18302-RA
Drosophila melanogaster Dmel_CG7329   CG7329 gene product from transcript CG7329-RB
Drosophila melanogaster Dmel_CG8823   CG8823 gene product from transcript CG8823-RA
Drosophila melanogaster Dmel_CG31871   CG31871 gene product from transcript CG31871-RA
Drosophila melanogaster Dmel_CG6113   Lipase 4
Drosophila melanogaster Dmel_CG7279   Lipase 1
Drosophila melanogaster Dmel_CG8093   CG8093 gene product from transcript CG8093-RB
Drosophila melanogaster Dmel_CG18301   CG18301 gene product from transcript CG18301-RA
Echinococcus granulosus EgrG_000357600   lysosomal acid lipase:cholesteryl ester
Echinococcus granulosus EgrG_000654850   lysosomal acid lipase:cholesteryl ester
Echinococcus multilocularis EmuJ_000917500   lysosomal acid lipase:cholesteryl ester
Echinococcus multilocularis EmuJ_000357600   lysosomal acid lipase:cholesteryl ester
Homo sapiens ENSG00000204021   lipase, family member K
Homo sapiens ENSG00000107798   lipase A, lysosomal acid, cholesterol esterase
Homo sapiens ENSG00000182333   lipase, gastric
Homo sapiens ENSG00000173239   lipase, family member M
Loa Loa (eye worm) LOAG_11804   hypothetical protein
Loa Loa (eye worm) LOAG_12367   ab-hydrolase associated lipase region family protein
Loa Loa (eye worm) LOAG_11805   hypothetical protein
Mus musculus ENSMUSG00000024781   lysosomal acid lipase A
Mus musculus ENSMUSG00000024771   lipase, family member K
Mus musculus ENSMUSG00000056078   lipase, family member M
Mus musculus ENSMUSG00000024768   lipase, gastric
Oryza sativa 4346369   Os09g0103100
Oryza sativa 4346120   Os08g0529800
Onchocerca volvulus OVOC5859   Lipase homolog
Onchocerca volvulus OVOC5858   Lipase homolog
Saccharomyces cerevisiae YKL140W   Tgl1p
Schistosoma japonicum Sjp_0027050   Lipase member M precursor, putative
Schistosoma japonicum Sjp_0131160   Lysosomal acid lipase/cholesteryl ester hydrolase precursor, putative
Schistosoma japonicum Sjp_0302430   ko:K01052 cholesterol esterase [EC3.1.1.13], putative
Schistosoma mansoni Smp_011000   lipase 1
Schistosoma mansoni Smp_146180   lipase 1
Schmidtea mediterranea mk4.031125.00  
Schmidtea mediterranea mk4.000217.16  
Schmidtea mediterranea mk4.000340.04  
Schmidtea mediterranea mk4.000220.12  
Schmidtea mediterranea mk4.001097.04  
Schmidtea mediterranea mk4.006902.04  
Schmidtea mediterranea mk4.000340.08  
Schmidtea mediterranea mk4.000340.09  
Schmidtea mediterranea mk4.004422.01  
Schmidtea mediterranea mk4.001097.03  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens lipase A, lysosomal acid, cholesterol esterase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0149 0.6107 1
0.0139 0.2828 0.7333
0.0139 0.2828 0.7333

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_12367 (Loa Loa (eye worm)), ab-hydrolase associated lipase region family protein
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