Detailed view for LOAG_08055

Basic information

TDR Targets ID: 944619
Loa Loa (eye worm), CMGC/MAPK/P38 protein kinase
Source Database / ID:  KEGG  

pI: 5.9518 | Length (AA): 392 | MW (Da): 44761 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004707   MAP kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

MAPK signaling pathway (KEGG)
FoxO signaling pathway (KEGG)

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 389 5ci6 (B) 32 394 41.00 0 1 1.42804 -0.52
14 384 2baj (A) 1 348 45.00 0 1 1.35533 0.05
19 385 3gc9 (B) 4 349 43.00 0 1 1.44612 -0.76
38 383 2b9h (A) 8 353 40.00 0 1 1.38955 -0.93
127 202 2izr (A) 114 190 30.00 0.15 0.74 0.332478 0.69

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_192907)

Species Accession Gene Product
Brugia malayi Bm1_54500   Mitogen-activated protein kinase
Caenorhabditis elegans CELE_F42G8.4   Protein PMK-3
Loa Loa (eye worm) LOAG_08055   CMGC/MAPK/P38 protein kinase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 34.2% 307 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 38.9% 347 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 34.1% 317 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 31.5% 311 aa Compounds References
Patiria pectinifera Cdc2 300 aa 31.6% 316 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 43.4% 371 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 34.5% 165 aa Compounds References
Xenopus laevis Aurora kinase B-A 361 aa 24.0% 337 aa Compounds References
Xenopus laevis Aurora kinase B-B 368 aa 25.6% 313 aa Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 26.4% 345 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0062 0.6935 0.6935
0.0061 0.6883 0.6883
0.0007 0.5 0.5
0.0008 0.5 0.5
0.0059 1 1
0.0007 0.5 0.5
0.0067 0.5 0.5
0.0036 0.5 0.5
0.0003 0.5 0.5
0.0011 1 1
0.0033 0.5 0.5
0.0012 0.5 0.5
0.0081 0.5 0.5
0.0026 0.5 0.5
0.0066 0.3101 0.3068
0.0004 0.5 0.5
0.0092 1 1
0.0018 0.5 0.5
0.0088 0.4477 0.4477
0.0016 0.5 0.5
0.0023 0.5 0.5
0.0037 1 0.5
0.0007 0.5 0.5
0.0042 0.5 0.5
0.0029 0.5 0.5
0.0069 0.3067 0.9179
0.0059 1 1
0.0056 1 1
0.0063 0.7244 0.6686
0.0091 1 1
0.0064 0.3377 0.3377
0.0022 0.5 0.5
0.0081 1 1
0.0033 1 1
0.0093 0.8828 0.8828
0.0063 1 1
0.0032 0.5 0.5
0.0039 0.5 0.5
0.0027 1 1
0.0012 0.5 0.5
0.0012 0.5 0.5
0.0098 0.3242 0.3017
0.0039 0.9485 1
0.0059 1 1
0.0039 0.5 0.5
0.0016 0.5 0.5
0.0032 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier LOAG_08055 (Loa Loa (eye worm)), CMGC/MAPK/P38 protein kinase
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