Detailed view for LOAG_02609

Basic information

TDR Targets ID: 944790
Loa Loa (eye worm), SPRY domain-containing protein
Source Database / ID:  KEGG  

pI: 6.6732 | Length (AA): 1365 | MW (Da): 152628 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00622   SPRY domain
PF02037   SAP domain
PF13671   AAA domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
11 53 1zrj (A) 0 36 37.00 0.33 0.97 0.615302 -1.51
1061 1174 4xw3 (A) 132 246 34.00 0.0000000033 0.98 0.502216 -0.3
1221 1354 1rrc (A) 3 136 16.00 0 0.27 0.0989685 0.09
1221 1351 1ltq (A) 3 134 17.00 0 0.42 0.165771 -0.04
1222 1309 4xrp (A) 13 90 33.00 0.55 0.63 0.285169 0.43

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130051)

Species Accession Gene Product
Brugia malayi Bm1_30855   SPRY domain containing protein
Caenorhabditis elegans CELE_Y41E3.11   Protein Y41E3.11, isoform D
Drosophila melanogaster Dmel_CG30122   CG30122 gene product from transcript CG30122-RB
Echinococcus granulosus EgrG_000460500   e1b 55 kda associated protein
Echinococcus multilocularis EmuJ_000460500   e1b 55 kda associated protein
Homo sapiens ENSG00000105323   heterogeneous nuclear ribonucleoprotein U-like 1
Homo sapiens ENSG00000153187   heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
Loa Loa (eye worm) LOAG_14888   hypothetical protein
Loa Loa (eye worm) LOAG_02609   SPRY domain-containing protein
Mus musculus ENSMUSG00000040725   heterogeneous nuclear ribonucleoprotein U-like 1
Mus musculus 51810   heterogeneous nuclear ribonucleoprotein U
Neospora caninum NCLIV_042490   SPRY domain-containing protein, putative
Oryza sativa 4337138   Os04g0636000
Schistosoma japonicum Sjp_0206660   Heterogeneous nuclear ribonucleoprotein U-like protein 1, putative
Schistosoma mansoni Smp_062720.1   E1b-55kD-associated protein
Schistosoma mansoni Smp_062720.3   E1b-55kD-associated protein
Schistosoma mansoni Smp_062720.5   E1b-55kD-associated protein
Schistosoma mansoni Smp_062720.2   E1b-55kD-associated protein
Schmidtea mediterranea mk4.004557.02   Putative e1b-55kD-associated protein
Toxoplasma gondii TGME49_290270   SPRY domain-containing protein

Essentiality

LOAG_02609 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y41E3.11 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y41E3.11 Caenorhabditis elegans larval arrest wormbase
CELE_Y41E3.11 Caenorhabditis elegans larval lethal wormbase
CELE_Y41E3.11 Caenorhabditis elegans slow growth wormbase
CELE_Y41E3.11 Caenorhabditis elegans sterile wormbase
TGME49_290270 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_02609 (Loa Loa (eye worm)), SPRY domain-containing protein
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