Detailed view for LOAG_11286

Basic information

TDR Targets ID: 944893
Loa Loa (eye worm), ubiquitin carboxyl-terminal hydrolase
Source Database / ID:  KEGG  

pI: 8.0407 | Length (AA): 497 | MW (Da): 56982 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00443   Ubiquitin carboxyl-terminal hydrolase
PF02148   Zn-finger in ubiquitin-hydrolases and other protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0036459   GO:thiol-dependent ubiquitinyl hydrolase activity  

GO:0016579   protein deubiquitination  
GO:0008270   zinc ion binding  
GO:0006511   ubiquitin-dependent protein catabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 489 4fk5 (A) 2 465 32.00 0 1 1.13928 0.33
3 491 2f1z (B) 87 520 18.00 0 1 0.947003 0.79
153 489 2hd5 (A) 211 518 36.00 0 1 1.00947 -0.49
435 485 5o71 (A) 591 644 41.00 0.063 0.66 0.498016 0.23

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129126)

Species Accession Gene Product
Arabidopsis thaliana AT5G10790   ubiquitin-specific protease 22
Brugia malayi Bm1_21375   Ubiquitin carboxyl-terminal hydrolase family protein
Candida albicans CaO19.9336   similar to ubiquitin carboxyl-terminal hydrolase
Candida albicans CaO19.1767   similar to ubiquitin carboxyl-terminal hydrolase
Dictyostelium discoideum DDB_G0271798   UBP-type zinc finger-containing protein
Drosophila melanogaster Dmel_CG4166   non-stop
Echinococcus granulosus EgrG_000042300   ubiquitin carboxyl terminal hydrolase 22
Echinococcus multilocularis EmuJ_000042300   ubiquitin carboxyl terminal hydrolase 22
Homo sapiens ENSG00000273820   ubiquitin specific peptidase 27, X-linked
Homo sapiens ENSG00000247746   ubiquitin specific peptidase 51
Homo sapiens ENSG00000124422   ubiquitin specific peptidase 22
Loa Loa (eye worm) LOAG_11286   ubiquitin carboxyl-terminal hydrolase
Mus musculus ENSMUSG00000046269   ubiquitin specific peptidase 27, X chromosome
Mus musculus ENSMUSG00000042506   ubiquitin specific peptidase 22
Mus musculus ENSMUSG00000067215   ubiquitin specific protease 51
Oryza sativa 4337205   Os04g0647300
Saccharomyces cerevisiae YMR223W   Ubp8p
Schistosoma japonicum Sjp_0023350   Ubiquitin carboxyl-terminal hydrolase 27, putative
Schistosoma japonicum Sjp_0023310   ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative
Schistosoma mansoni Smp_074400   ubiquitin-specific peptidase 22 (C19 family)
Schmidtea mediterranea mk4.005017.00  
Schmidtea mediterranea mk4.001299.02   Ubiquitin carboxyl-terminal hydrolase
Schmidtea mediterranea mk4.001342.02  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0003 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_11286 (Loa Loa (eye worm)), ubiquitin carboxyl-terminal hydrolase
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