pI: 7.4684 |
Length (AA): 256 |
MW (Da): 29233 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
100 | 225 | 1so9 (A) | 23 | 148 | 39.00 | 0 | 1 | 0.956788 | 0.12 |
113 | 149 | 3uue (A) | 105 | 143 | 46.00 | 0.52 | 0.21 | 0.440231 | 1.29 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128258)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G02410 | cytochrome c oxidase assembly protein CtaG / Cox11 |
Babesia bovis | BBOV_IV000820 | cytochrome c oxidase assembly protein Cox11 subunit |
Brugia malayi | Bm1_49700 | Cytochrome c oxidase assembly protein CtaG / Cox11 containing protein |
Candida albicans | CaO19.1416 | assembly of cytochrome c oxidase |
Candida albicans | CaO19.8992 | assembly of cytochrome c oxidase |
Caenorhabditis elegans | CELE_JC8.5 | Protein JC8.5 |
Dictyostelium discoideum | DDB_G0289353 | cytochrome c oxidase assembly protein |
Drosophila melanogaster | Dmel_CG31648 | CG31648 gene product from transcript CG31648-RA |
Echinococcus granulosus | EgrG_000923400 | Cytochrome c oxidase assembly protein COX11 |
Echinococcus multilocularis | EmuJ_000923400 | Cytochrome c oxidase assembly protein COX11 |
Homo sapiens | ENSG00000166260 | COX11 cytochrome c oxidase copper chaperone |
Leishmania braziliensis | LbrM.03.0110 | cytochrome c oxidase assembly protein, putative |
Leishmania donovani | LdBPK_030090.1 | cytochrome c oxidase assembly protein, putative |
Leishmania infantum | LinJ.03.0090 | cytochrome c oxidase assembly protein, putative |
Leishmania major | LmjF.03.0100 | cytochrome c oxidase assembly protein, putative |
Leishmania mexicana | LmxM.03.0100 | cytochrome c oxidase assembly protein, putative |
Loa Loa (eye worm) | LOAG_00124 | cytochrome c oxidase assembly protein CtaG/Cox11 containing protein |
Mus musculus | 69802 | cytochrome c oxidase assembly protein 11 |
Neospora caninum | NCLIV_022110 | cytochrome C oxidase assembly protein cox11, putative |
Oryza sativa | 4333922 | Os03g0718600 |
Plasmodium berghei | PBANKA_1300900 | cytochrome c oxidase assembly protein COX11, putative |
Plasmodium falciparum | PF3D7_1475300 | cytochrome c oxidase assembly protein COX11, putative |
Plasmodium knowlesi | PKNH_1245600 | cytochrome c oxidase assembly protein COX11, putative |
Plasmodium vivax | PVX_118645 | cytochrome c oxidase assembly protein COX11, putative |
Plasmodium yoelii | PY00708 | Caenorhabditis elegans JC8.5 |
Saccharomyces cerevisiae | YPL132W | Cox11p |
Schistosoma japonicum | Sjp_0014940 | ko:K02258 cytochrome c oxidase subunit XI assembly protein, putative |
Schistosoma mansoni | Smp_141470 | cytochrome C oxidase assembly protein cox11 |
Schmidtea mediterranea | mk4.024417.00 | Cytochrome c oxidase assembly protein COX11, mitochondrial |
Schmidtea mediterranea | mk4.007375.00 | Cytochrome c oxidase assembly protein COX11, mitochondrial |
Trypanosoma brucei gambiense | Tbg972.10.3950 | cytochrome c oxidase assembly protein, putative |
Trypanosoma brucei | Tb927.10.3120 | cytochrome c oxidase assembly protein, putative |
Trypanosoma congolense | TcIL3000_10_2580 | cytochrome c oxidase assembly protein, putative |
Trypanosoma cruzi | TcCLB.504867.70 | cytochrome c oxidase assembly protein, putative |
Trypanosoma cruzi | TcCLB.510943.130 | cytochrome c oxidase assembly protein, putative |
Toxoplasma gondii | TGME49_202800 | cytochrome c oxidase assembly protein COX11 protein, putative |
Theileria parva | TP01_0104 | cytochrome c oxidase assembly protein, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0491 | cytochrome C oxidase assembly protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.3120 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.3120 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.3120 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.3120 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_JC8.5 | Caenorhabditis elegans | slow growth | wormbase |
PBANKA_1300900 | Plasmodium berghei | Essential | plasmo |
TGME49_202800 | Toxoplasma gondii | Probably essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.