Detailed view for LOAG_02729

Basic information

TDR Targets ID: 945067
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 7.5054 | Length (AA): 378 | MW (Da): 42150 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00226   DnaJ domain
PF08477   Ras of Complex, Roc, domain of DAPkinase

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 10 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 67 3ucs (C) 3 72 25.00 0 0.91 0.633949 -1.74
3 77 2ctr (A) 8 84 31.00 0 1 0.633513 -0.83
3 64 2cug (A) 18 82 40.00 0 1 0.736121 -1.2
171 319 4djt (B) 0 154 14.00 0.000000031 0.19 0.54128 -0.06
177 361 4u5x (A) 6 179 16.00 0.000000035 0.3 0.622518 -0.21
187 361 1vg8 (A) 1017 1171 19.00 0 0.86 0.575063 0.06
189 333 1ek0 (A) 18 137 23.00 0 0.15 0.331698 0.69
208 325 2o52 (A) 16 129 29.00 0.000048 0.76 0.192769 0.82
218 368 2fu5 (C) 45 174 28.00 0.000000004 0.36 0.284571 0.43
236 276 2fol (A) 51 103 36.00 0.83 0.06 0.259066 1.52

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132423)

Species Accession Gene Product
Arabidopsis thaliana AT5G09910   Ras-related small GTP-binding family protein
Arabidopsis thaliana AT5G64813   protein LIGHT INSENSITIVE PERIOD1
Brugia malayi Bm1_06385   Ras-related protein ypt4
Caenorhabditis elegans CELE_Y116A8C.10   Protein Y116A8C.10, isoform B
Dictyostelium discoideum DDB_G0286513   Rab GTPase domain-containing protein
Drosophila melanogaster Dmel_CG4789   CG4789 gene product from transcript CG4789-RA
Echinococcus granulosus EgrG_001106200   rab protein 3
Echinococcus multilocularis EmuJ_001106200   rab protein 3
Homo sapiens ENSG00000144840   RAB, member of RAS oncogene family-like 3
Loa Loa (eye worm) LOAG_02729   hypothetical protein
Mus musculus ENSMUSG00000022827   RAB, member RAS oncogene family-like 3
Oryza sativa 4332217   Os03g0242200
Oryza sativa 4348056   Os10g0135200
Onchocerca volvulus OVOC13456  
Schistosoma japonicum Sjp_0054600   ko:K07933 Rab-like protein 3, putative
Schmidtea mediterranea mk4.006161.02   Rab-like protein 3
Schmidtea mediterranea mk4.004671.01   Rab-like protein 3

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_02729 (Loa Loa (eye worm)), hypothetical protein
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