Detailed view for LOAG_01603

Basic information

TDR Targets ID: 945400
Loa Loa (eye worm), complex I intermediate-associated protein 30
Source Database / ID:  KEGG  

pI: 8.4247 | Length (AA): 636 | MW (Da): 72593 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00076   RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PF08547   Complex I intermediate-associated protein 30 (CIA30)

Gene Ontology

Mouse over links to read term descriptions.
GO:0003676   nucleic acid binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
343 404 2dh7 (A) 105 167 32.00 0.0053 0.98 0.397584 0.96
355 395 2jvo (A) 52 84 52.00 0.18 0.29 0.187565 1.74
520 565 2ywk (A) 42 87 13.00 0.8 0.03 0.203027 -0.13
530 566 2mpu (A) 52 88 8.00 0.24 0.01 0.193876 -0.7

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129899)

Species Accession Gene Product
Arabidopsis thaliana AT1G72420   NADH:ubiquinone oxidoreductase intermediate-associated protein 30
Arabidopsis thaliana AT1G17350   NADH:ubiquinone oxidoreductase intermediate-associated protein 30
Brugia malayi Bm1_51975   Probable complex I intermediate-associated protein 30, mitochondrialprecursor.
Candida albicans CaO19.10861   similar to N. crassa complex I intermediate associated protein CIA30 (CAA04954), chaperone for mitochondrial NADH-ubiquinone oxi
Caenorhabditis elegans CELE_C50B8.3   Protein NUAF-1
Dictyostelium discoideum DDB_G0275973   hypothetical protein
Drosophila melanogaster Dmel_CG7598   CG7598 gene product from transcript CG7598-RA
Homo sapiens ENSG00000137806   NADH dehydrogenase (ubiquinone) complex I, assembly factor 1
Loa Loa (eye worm) LOAG_01603   complex I intermediate-associated protein 30
Mus musculus ENSMUSG00000027305   NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 1
Oryza sativa 4324734   Os01g0727400
Schmidtea mediterranea mk4.001381.03   Probable complex I intermediate-associated protein 30, mitochondrial

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0418 0.2629 0.6013
0.0414 0.3002 0.5818
0.0405 0.2954 0.5766
0.041 0.2984 0.499
0.0406 0.3265 0.4627
0.0436 0.2607 0.588
0.0406 0.3265 0.4627
0.0242 0.2753 0.5523
0.0403 0.2938 0.5058
0.0427 0.2562 0.5505
0.0415 0.2993 0.5366
0.0452 0.2656 0.591
0.0409 0.2965 0.5779
0.0433 0.294 0.5083
0.0424 0.2953 0.5017
0.0442 0.2592 0.5856
0.0432 0.2525 0.549

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_01603 (Loa Loa (eye worm)), complex I intermediate-associated protein 30
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