Detailed view for LOAG_01107

Basic information

TDR Targets ID: 945898
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 6.2928 | Length (AA): 204 | MW (Da): 22187 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00890   FAD binding domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
32 202 1y0p (A) 121 286 36.00 0.0000000051 1 1.27924 -0.23
34 197 1qo8 (A) 118 276 34.00 0.0000016 1 1.23792 -0.36
40 87 2i0z (A) 5 50 46.00 0.027 0.71 0.679694 0.35
40 74 2b9w (A) 9 43 31.00 0 0.31 0.475569 0.21

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128620)

Species Accession Gene Product
Brugia malayi Bm1_04850   Hypothetical FAD-dependent oxidoreductase YEL047C, putative
Candida albicans CaO19.12472   potential fumarate reductase
Candida albicans CaO19.6882   similar to S. cerevisiae cytoplasmic (YEL047C) and mitochondrial (OSM1, YJR051W) soluble fumarate reductases required for anaero
Candida albicans CaO19.14171   similar to S. cerevisiae cytoplasmic (YEL047C) and mitochondrial (OSM1, YJR051W) soluble fumarate reductases required for anaero
Candida albicans CaO19.5005   potential fumarate reductase
Caenorhabditis elegans CELE_F48E8.3   Protein F48E8.3
Leishmania braziliensis LbrM.34.1110   NADH-dependent fumarate reductase, putative
Leishmania braziliensis LbrM.34.1100   NADH-dependent fumarate reductase, putative
Leishmania braziliensis LbrM.34.0820   NADH-dependent fumarate reductase-like protein
Leishmania braziliensis LbrM.34.1090   NADH-dependent fumarate reductase, putative
Leishmania donovani LdBPK_350850.1   NADH-dependent fumarate reductase-like protein
Leishmania donovani LdBPK_351200.1   NADH-dependent fumarate reductase, putative
Leishmania donovani LdBPK_070910.1   flavoprotein subunit-like protein
Leishmania donovani LdBPK_351190.1   NADH-dependent fumarate reductase, putative
Leishmania infantum LinJ.35.1190   NADH-dependent fumarate reductase, putative
Leishmania infantum LinJ.35.1200   NADH-dependent fumarate reductase, putative
Leishmania infantum LinJ.07.0910   flavoprotein subunit-like protein
Leishmania infantum LinJ.35.0850   NADH-dependent fumarate reductase-like protein
Leishmania major LmjF.35.0830   NADH-dependent fumarate reductase-like protein
Leishmania major LmjF.35.1190   NADH-dependent fumarate reductase, putative
Leishmania major LmjF.35.1180   NADH-dependent fumarate reductase, putative
Leishmania major LmjF.07.0800   flavoprotein subunit-like protein
Leishmania mexicana LmxM.34.0830   NADH-dependent fumarate reductase-like protein
Leishmania mexicana LmxM.34.1180   NADH-dependent fumarate reductase, putative
Leishmania mexicana LmxM.07.0800   flavoprotein subunit-like protein
Leishmania mexicana LmxM.34.1190   NADH-dependent fumarate reductase, putative
Loa Loa (eye worm) LOAG_01110   hypothetical protein
Loa Loa (eye worm) LOAG_01107   hypothetical protein
Onchocerca volvulus OVOC2551  
Saccharomyces cerevisiae YJR051W   Osm1p
Saccharomyces cerevisiae YEL047C   Frd1p
Trypanosoma brucei gambiense Tbg972.5.6520   NADH-dependent fumarate reductase, putative
Trypanosoma brucei gambiense Tbg972.10.4540   NADH-dependent fumarate reductase, putative
Trypanosoma brucei gambiense Tbg972.5.1290   NADH-dependent fumarate reductase
Trypanosoma brucei Tb11.v5.0613   NADH-dependent fumarate reductase, putative
Trypanosoma brucei Tb927.10.3650   NADH-dependent fumarate reductase
Trypanosoma brucei Tb927.5.930   NADH-dependent fumarate reductase
Trypanosoma brucei Tb927.5.940   NADH-dependent fumarate reductase, putative
Trypanosoma congolense TcIL3000_5_640   NADH-dependent fumarate reductase
Trypanosoma congolense TcIL3000_5_630   NADH-dependent fumarate reductase
Trypanosoma congolense TcIL3000_10_2980   NADH-dependent fumarate reductase
Trypanosoma congolense TcIL3000_0_22370   NADH-dependent fumarate reductase
Trypanosoma congolense TcIL3000_0_22360   NADH-dependent fumarate reductase
Trypanosoma cruzi TcCLB.510215.10   NADH-dependent fumarate reductase, putative
Trypanosoma cruzi TcCLB.508535.10   NADH-dependent fumarate reductase, putative
Trypanosoma cruzi TcCLB.503849.80   NADH-dependent fumarate reductase, putative
Trypanosoma cruzi TcCLB.510213.110   NADH-dependent fumarate reductase, putative
Trypanosoma cruzi TcCLB.503849.60   NADH-dependent fumarate reductase, putative

Essentiality

LOAG_01107 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.5.930 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.5.930 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.5.930 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.5.930 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.10.3650 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.3650 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.3650 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.3650 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.5.940 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.5.940 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.5.940 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.5.940 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0032 0.5 0.5
0.0032 0.5 0.5
0.0032 0.5 0.5
0.0032 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier LOAG_01107 (Loa Loa (eye worm)), hypothetical protein
Title for this comment
Comment